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中国临床药理学与治疗学 ›› 2002, Vol. 7 ›› Issue (4): 341-343.

• 临床研究 • 上一篇    下一篇

苯那普利单用和与氯沙坦联用治疗慢性充血性心衰的临床评价

童学敏, 胡兆良, 程圣军1   

  1. 上海市浦东新区黄楼医院内科, 上海 201205;
    1安徽省东至县第二人民医院内科, 东至 247201
  • 收稿日期:2002-05-12 修回日期:2002-06-08 出版日期:2002-08-26 发布日期:2020-11-24
  • 通讯作者: 童学敏, 男, 主治医师, 主要从事心血管内科临床工作。Tel:021-58941883

Clinical evaluation of benazepril alone and combined with losartan in the treatment of congestive heart failure

TONG Xue-Min, HU Zhao-Liang, CHENG Sheng-Jun1   

  1. Huanglou Hospital of Pudong New Region, Shanghai 201205;
    1Second Hospital of Dongzhi County, Dongzhi, Anhui 247201
  • Received:2002-05-12 Revised:2002-06-08 Online:2002-08-26 Published:2020-11-24

摘要: 目的: 观察苯那普利单用和与氯沙坦联用治疗慢性充血性心衰( CHF) 的疗效和耐受性。方法: 34例CHF 病人, NYHA Ⅱ ~ Ⅳ级, 随机分为两组:苯那普利组和苯那普利+氯沙坦组。观察治疗前后症状、体征、心胸比率、左室舒张末内径( LVDd) 和左室射血分数( LVEF) 。结果: 两组NYHA 级别改善效果相似, 但对心脏结构和功能改善的效果苯那普利+氯沙坦组优于苯那普利组。而且血清钾、肌酐无明显变化, 未出现严重副反应。结论: 联用苯那普利和氯沙坦治疗CHF 的效果比单用苯那普利好, 耐受性良好。

关键词: 苯那普利, 氯沙坦, 慢性充血性心衰

Abstract: AIM: To evaluate the efficacy of benazepril alone and combined with losartan in the treatment of congestive heart failure ( CHF). MATHODS: 34 patients with class Ⅱ-Ⅳ( NYHA) CHF were divided into two groups: benazepril group and benazepril +losartan group. The treatment course lasted 3 mon. RESULTS: NYHA class in both groups were significantly improved. There was no significant difference in effective rate between two groups ( 88. 9 % vs 87. 5 %, P >0. 05). However, benazepril +losartan group was better than benazepril group in improving heart composition and function ( P <0. 05). CONCLUSION: The combination of benazepril and losartan is prior to benazepril alone in the treatment of CHF.

Key words: benazepril, losartan, congestive heart failure

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