氟西汀治疗阻塞型睡眠呼吸暂停低通气综合征

中国临床药理学与治疗学 ›› 2003, Vol. 8 ›› Issue (2): 133-135.

氟西汀治疗阻塞型睡眠呼吸暂停低通气综合征

李玉柱, 刘又宁, 郝峰英

解放军总医院呼吸科, 北京 100853

收稿日期:2002-12-28 修回日期:2003-01-03 出版日期:2003-04-26 发布日期:2020-11-25
通讯作者: 李玉柱, 男, 硕士, 主治医师, 从事睡眠呼吸障碍的研究。Tel:010-66937551 E-mail:osas@sohu.com;lyz301@163.com

Efficacy of fluoxetine in treatment of patients with the obstructive sleep apnea-hypopnea syndrome

LI Yu-Zhu, LIU You-Ning, HAO Feng-Ying

Department of Respiratory Diseases, General Hospital of PLA, Beijing 100853

Received:2002-12-28 Revised:2003-01-03 Online:2003-04-26 Published:2020-11-25

摘要/Abstract

摘要： 目的: 评估氟西汀对阻塞型睡眠呼吸暂停低通气综合征(OSAHS) 的治疗反应。方法: 10 例经多导睡眠图(PSG) 诊断的OSAHS 患者, 进行Epworth 嗜睡量表(ESS) 评估后, 开始应用氟西汀(每日20 mg口服) 治疗, 4 wk 后重复检查PSG 及ESS。用配对t检验方法进行统计处理。结果: 氟西汀治疗4 wk后, 患者REM 睡眠比例平均减少9.2%, ESS 评估平均降低2 分, 有显著的统计学意义(P <0.01), 睡眠潜伏期无明显变化(P >0.05);睡眠呼吸暂停及低通气指数(AHI) 平均下降24.8·h^-1, 平均血氧饱和度和最低血氧饱和度分别升高3.2%、16.6%, 氧减饱和指数平均下降18.2·h^-1 (P <0.01), 平均暂停时间无统计学意义(P >0.05);5 例AHI 下降超过一半, 治疗有效率为50%。结论: OSAHS 患者短期服用氟西汀可部分改善睡眠质量和缺氧状况, 减少呼吸暂停和低通气事件。

关键词: 药效学, 氟西汀, 阻塞型睡眠呼吸暂停, 多导睡眠图, Epworth 嗜睡量表

Abstract: AIM: To evaluate the response of obstructive sleep apnea-hypopnea syndrome (OSAHS) to fluoxetine.METHODS: After a baseline polysomnography (PSG) and Epworth Sleepiness Scale (ESS) documented OSAHS, 10 patients were treated with fluoxetine (20 mg· d ^-1) for four weeks, a repeating PSG and ESS was performed to evaluate the action of fluoxetine.RESULTS: After 4 weeks fluoxetine treatment, the proportion of REM sleep time was decreased by 9.2%, and the assessment of ESS was significantly decreased (P <0.01).The differences in sleep latency were not statistically significance (P >0.05).The apnea hypopnea index (AHI) fell in average 24.84 per hour, the mean SaO2 and minimum SaO2 significantly increased by 3.2% and 16.6%, respectively, and desaturation event index significantly decreased 18.24 per hour (P <0.01).The mean duration of apnea had no statistically significant differences (P > 0.05).The treatment efficiency of fluoxetine to OSAHS was 50%.CONCLUSION: Short-term use of fluoxetine in patients with OSAHS is associated with better sleep quality, improvement in oxygenation, and reduction of episodic apneas or hypopneas.

Key words: pharmacodynamics, fluoxetine, obstructive sleep apnea, epworth sleepiness scale, polysomnography

中图分类号:

R971.4
R969

李玉柱, 刘又宁, 郝峰英. 氟西汀治疗阻塞型睡眠呼吸暂停低通气综合征[J]. 中国临床药理学与治疗学, 2003, 8(2): 133-135.

LI Yu-Zhu, LIU You-Ning, HAO Feng-Ying. Efficacy of fluoxetine in treatment of patients with the obstructive sleep apnea-hypopnea syndrome[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2003, 8(2): 133-135.

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