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中国临床药理学与治疗学 ›› 1997, Vol. 2 ›› Issue (1): 13-15.

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阿莫西林与庆大霉素或奈替米星联合应用PAE的比较

王睿, 刘皈阳, 周亮, 方翼, 陈迁, 刘庆锋   

  1. 解放军总医院临床药理研究室,北京100853
  • 收稿日期:1996-11-26 出版日期:1997-03-26 发布日期:2020-12-04
  • 作者简介:王睿,女,48岁,副研究员,硕士研究生导师,主要从事临床药理学研究。

The Comparision of Combined Postantibiotic Effects Induced by Amoxacillin Plus Gentamicin or Netilmicin

Wang Rui, Liu Guiyang, Zhou Liang, Fang Yi, Chen Qian, Liu Qingfeng   

  1. Unit of Clini, Pharmacol, Chinese PLA General Hospital, Beijing 100853
  • Received:1996-11-26 Online:1997-03-26 Published:2020-12-04

摘要: 目的 阿莫西林(AMPC)与庆大霉素(GM)或奈替米星(NTL)联合应用抗生素后效应(PAE)的比较。方法 应用光密度法测定PAE。结果 AMPC单用时对金黄色葡萄球菌和粪肠球菌有较长的PAE,对大肠埃希氏菌PAE甚小;GM和NTL单用对G'球菌的PAE亦很明显,对大肠埃希氏菌PAE稍短,但比单用AMPC要长。NTL的PAE比GM长,可能与受试菌对NTL敏感性高于GM有关。三种药物PAE均有随药物浓度增加而延长的趋势。AMPC与4倍MIC的GM或NTL联用时对受试菌的PAE均呈协同或相加效应;对G+球菌的联合PAE比G-杆菌明显延长;AMPC与NTL的联合PAE长于与GM联合的PAE。结论 AMPC与GM或NTL联用时延长给药间隔,仍可维持强大的抗菌活性,减轻不良反应,AMPC与NTL联用优于与GM联用。

关键词: 阿莫西林, 庆大霉素, 奈替米星, 抗生素后效应

Abstract: Aim The postantibiotic effects(PAEs)induced by Amoxacillin(AMPC)alone or com-bined with gentamicin(GM)or netilmycin(NTL)were studied.Methods The PAEs were determined by the spectrophotometric method.Results The PAEs induced by AM- PC alone to S.aureus and E.faecalis were long;whereas to E.coli, the PAEs were poor.PAEs induced by GM or NTL alone to Gram-positive cocci were longer than to Gram-negative bacilli.The PAEs of NTL were more obvious than those of GM.The PAEs of AMPC combined with 4x MIC of GM or NTL were all synergic or additive, and the combined PAEs to Gram-positive cocci were longer than to Gram-negative bacilli.The combined PAEs of AMPC plus NTL were more obvious than plus GM.Conclusion It is suggested that the rational prelonged dosing intervals in combinations of AMPC with two aminoglycosides should be recommended.

Key words: amoxacillin, gentamicin, netilmicin, PAE

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