抗环瓜氨酸肽抗体在系统性红斑狼疮关节炎中意义

中国临床药理学与治疗学 ›› 2011, Vol. 16 ›› Issue (5): 568-573.

抗环瓜氨酸肽抗体在系统性红斑狼疮关节炎中意义

毛桐俊, 许国飞, 盛君, 李志, 宣丹, 张军, 陆进明, 徐亮

皖南医学院弋矶山医院风湿免疫科,芜湖 241001,安徽

收稿日期:2011-02-17 修回日期:2011-03-28 发布日期:2011-07-08
作者简介:毛桐俊,女,本科,住院医师,研究方向:风湿免疫病学。Tel:13955607724 E-mail:maomaoab@chinaren.com

Significance of anti-cyclic citrullinated peptides antibodies in patients of systemic lupus erythematosus with arthritis

MAO Tong-jun, XU Guo-fei, SHENG Jun, LI Zhi, XUAN Dan, ZHANG Jun, LU Jin-ming, XU Liang

Department of Rheumatology,Yijishan Hospital,Wannan Medical College,Wuhu 241000,Anhui,China

Received:2011-02-17 Revised:2011-03-28 Published:2011-07-08

摘要/Abstract

摘要： 目的: 检测抗环瓜氨酸肽(CCP)抗体在系统性红斑狼疮(SLE)患者中的水平,探索抗CCP抗体与SLE患者关节炎及骨侵蚀的关系。方法: 采用酶联免疫吸附试验(ELISA)方法检测141例SLE患者血清中抗CCP抗体水平,并与SLE患者关节临床表现及其他实验室指标进行相关性分析。结果: 抗CCP抗体在SLE患者中的阳性率为 20.6%(29/141)。其中,在SLE关节炎组抗CCP抗体阳性率为 26.7%(20/75),非关节炎组抗CCP抗体阳性率为 13.6%(9/66),两者间比较相近(P=0.056),但是SLE关节炎组抗CCP抗体中位水平为 16 RU/mL(5~1600 RU/mL)高于非关节炎组的 12 RU/mL(4~51 RU/mL)(P=0.004)。抗CCP抗体阳性SLE患者中关节炎组抗CCP抗体中位水平为 304.5 RU/mL(28~1600 RU/mL),也明显高于非关节炎组的 30.0 RU/mL(28~51 RU/mL) (P=0.001)。在75例SLE有关节炎表现的患者中,有6例患者出现侵蚀性关节炎,其中5例检测出高滴度抗CCP抗体[459 RU/mL (76~605 RU/mL)]。结论: 在SLE中,20.6%的患者体内存在抗CCP抗体,对于有关节炎表现的SLE患者伴有高滴度的抗CCP抗体,可能会发生侵蚀性关节炎,抗CCP抗体对判断SLE关节炎具有重要意义。

关键词: 红斑狼疮, 系统性, 关节炎, 抗环瓜氨酸肽抗体

Abstract: AIM: To detect the level of anti-cyclic citrullinated peptides(anti-CCP) antibodies in systemic lupus erythematosus(SLE) patients with arthritis,and explore the relationship of anti-CCP antibodies with erosive arthritis in SLE patients.METHODS: The levels of anti-CCP antibodies in 141 case patients with SLE were detected by ELISA.The dependablity between anti-CCP antibodies and clinical features as well as laboratory parameters in these SLE patients were analyzed.RESULTS: The positive rate of anti-CCP in SLE patients was 20.6%(29/141). The positive rate of anti-CCP in SLE patients with arthritis was 26.7%(20/75),which in SLE patients without arthritis was 13.6%(9/66),there was no significant difference(P=0.056). But the level of in anti-CCP in SLE patients with arthritis(16 RU/mL) was higher than that in SLE patients without arthritis(12 RU/mL,P=0.004) .In anti-CCP antibodies positive SLE patients,the level in arthritis patients (304.5 RU/mL)was higher than that in without arthritis patients(30.0 RU/mL) (P=0.001).There were 6 SLE patients with erosive arthritis in all subjects and high level anti-CCP antibodies(459 RU/mL) were detected in 5 patients.CONCLUSION: Anti-CCP antibodies can be found in 20.6% of patients with SLE, the patients who had high level of anti-CCP antibodies might initiate erosive arthritis. Anti-CCP antibodies is important to identify SLE patients with arthritis.

Key words: Lupus erythematosus, Systemic, Arthritis, Anti-cyclic citrullinated peptides antibodies

中图分类号:

R593.24

毛桐俊, 许国飞, 盛君, 李志, 宣丹, 张军, 陆进明, 徐亮. 抗环瓜氨酸肽抗体在系统性红斑狼疮关节炎中意义[J]. 中国临床药理学与治疗学, 2011, 16(5): 568-573.

MAO Tong-jun, XU Guo-fei, SHENG Jun, LI Zhi, XUAN Dan, ZHANG Jun, LU Jin-ming, XU Liang. Significance of anti-cyclic citrullinated peptides antibodies in patients of systemic lupus erythematosus with arthritis[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(5): 568-573.

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