T细胞异常活化在系统性红斑狼疮中的分子免疫机制

摘要/Abstract

摘要： 系统性红斑狼疮(SLE)是一种系统性自身免疫性疾病,其发病机制错综复杂。T细胞参与SLE自身免疫的启动和整个过程,且直接促进SLE受累器官的病理改变。其活化异常引起的细胞因子产生失衡、自身反应性T细胞持续存在、T细胞凋亡增加等,在SLE发病机制中发挥关键的作用。本文就近年来发现的SLE患者中T细胞活化在细胞膜信号,胞内激酶和转录因子等各个水平的异常及其对SLE发生发展的影响加以综述。

关键词: 系统性红斑狼疮, T细胞, T细胞活化

Abstract: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease, whose pathogenesis is very complicated. T cells contribute to the initiation and perpetuation of autoimmunity in SLE, and seem to be directly involved in the development of related organ pathology. Abnormal T cell activation could result in cytokine imbalance,the persistence of auto-reactive T cells, increased T cells apoptosis, these changes play pivotal role in SLE pathogenesis. This article presents an overview of the current research of abnormal T cell activation in SLE, include disorder of cell membrane signal, intracellular kinase, and transcription factor,and their effect on the occur and development of SLE.

Key words: Systemic lupus erythematosus, T cell, T cell activation

中图分类号:

R593.24⁺1

赵海慧, 赵阴环. T细胞异常活化在系统性红斑狼疮中的分子免疫机制[J]. 中国临床药理学与治疗学, 2012, 17(4): 452-457.

ZHAO Hai-hui, ZHAO Yin-huan. Molecular immunological mechanism of abnormal activated T cell in systemic lupus erythematosus[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(4): 452-457.

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