雾化吸入高渗盐水辅助治疗婴儿重症肺炎疗效观察

中国临床药理学与治疗学 ›› 2013, Vol. 18 ›› Issue (7): 804-806.

雾化吸入高渗盐水辅助治疗婴儿重症肺炎疗效观察

刘颖¹, 史道华, 王世彪², 郭晓峰², 朱杰君¹

¹福建省妇幼保健院药剂科;
²儿童救护中心,福州 350001,福建

收稿日期:2013-01-03 修回日期:2013-05-23 出版日期:2013-07-26 发布日期:2013-06-20
通讯作者: 史道华,男,教授,主任药师,硕士生导师,研究方向:临床药学与药理学。Tel: 0591-88312079 E-mail: shidh@yeah.net
作者简介:刘颖,女,硕士,主管药师,研究方向:临床药学。Tel: 0591-88312079 E-mail: 406522471@qq.com

Effects of aerosol inhalation of hypertonic saline on severe pneumonia in children

LIU Ying¹, SHI Dao-hua¹, WANG Shi-biao², GUO Xiao-feng², ZHU Jie-jun¹

¹Department of Pharmacy;
²Pediatric Intensive Care Unit, Fujian Provincial Maternity and Child Health Hospital, Fuzhou 350001,Fujian, China

Received:2013-01-03 Revised:2013-05-23 Online:2013-07-26 Published:2013-06-20

摘要/Abstract

摘要： 目的: 观察高渗盐水雾化吸入辅助治疗婴儿重症肺炎的疗效。方法: 重症肺炎患儿(< 1岁)随机分为研究组(n=43)和对照组(n=47),在相同综合治疗基础上,研究组雾化吸入高渗盐水(4.3% NaCl)和布地奈德 0.5 mg,对照组雾化吸入生理盐水(0.9% NaCl)和布地奈德 0.5 mg,3次/d。比较两组患者症状与体征消失天数及住院费用。结果: 与对照组相比,研究组患者使用持续正压通气时间明显减少,咳嗽消失时间缩短,吸气性三凹征消失时间减少,医疗费用减少(P<0.05);而呼吸频率恢复正常时间、啰音消失时间、入住时间无统计学差异。两组患者均无明显不良反应。结论: 高渗盐水辅助治疗婴儿重症肺炎疗效确切,有一定临床推广应用价值。

关键词: 婴儿, 重症肺炎, 高渗盐水, 布地奈德, 雾化吸入

Abstract: AIM: To observe the efficacy of aerosol inhalation of hypertonic saline on severe pneumonia in children.METHODS: Patients with severe pneumonia in the pediatric intensive care unit were randomly divided into experiment group and control group. With the same comprehensive treatment, the patients in the experiment group were treated with aerosol inhalation of hypertonic saline (4.3% NaCl) and budesonide 0.5 mg; while the patients in the control group were treated with aerosol inhalation of physiological saline (0.9% NaCl) and budesonide 0.5 mg. The time of symptoms and signs disappeared days and costs for hospitalization were observed.RESULTS: Compared with control group, the duration of continuous positive airway pressure (CPAP), cough and breath retraction were reduced, and the costs of hospitalization were also decreased(P<0.05).CONCLUSION: The better efficacy is achieved by treated with hypertonic saline in children with severe pneumonia. This strategy is worthy of clinical application.

Key words: Children, Severe pneumonia, Hypertonic saline, Budesonide, Inhalation

中图分类号:

R722.13

刘颖, 史道华, 王世彪, 郭晓峰, 朱杰君. 雾化吸入高渗盐水辅助治疗婴儿重症肺炎疗效观察[J]. 中国临床药理学与治疗学, 2013, 18(7): 804-806.

LIU Ying, SHI Dao-hua, WANG Shi-biao, GUO Xiao-feng, ZHU Jie-jun. Effects of aerosol inhalation of hypertonic saline on severe pneumonia in children[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(7): 804-806.

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