NF-κB/mTOR双信号通路的交联及其对肿瘤生物学特性的影响

摘要/Abstract

摘要： 肿瘤的发生发展涉及多个细胞信号传导通路,其中核因子-κB(Nuclear factor-kappaB,NF-κB)通路和哺乳动物雷帕霉素靶蛋白(Mammalian target of rapamycin,mTOR)通路尤为重要,已成为研究肿瘤药物治疗的新靶点。进一步探讨两信号通路间存在的交联(Cross-talk)及其对肿瘤生物学特性的影响,有助于更好地调控肿瘤细胞的恶性行为。

关键词: 肿瘤, NF-κB, mTOR, 信号通路, 交联

Abstract: Tumor development involves multiple cell signaling pathways. The most important of them are nuclear factor-kappaB (NF-κB) pathway and mammalian target of rapamycin pathway (mTOR), which is the new target for cancer treatment of drug therapy. Further exploration on the cross-talk between these two signaling pathways and its effects on tumor biological characteristics might be useful to control the malignant behavior of tumor cells.

Key words: Tumor, NF-κB, mTOR, Signaling pathway, Cross-talk

中图分类号:

陈华娇, 史道华. NF-κB/mTOR双信号通路的交联及其对肿瘤生物学特性的影响[J]. 中国临床药理学与治疗学, 2013, 18(11): 1315-1320.

CHEN Hua-jiao, SHI Dao-hua. Cross-talk between NF-κB and mTOR signaling pathways and its effects on tumor biological characteristics[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(11): 1315-1320.

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