曲普利啶胶囊联合复方麻黄碱色甘酸钠膜治疗变应性鼻炎疗效及其对血清炎性因子影响

中国临床药理学与治疗学 ›› 2017, Vol. 22 ›› Issue (2): 160-164.

曲普利啶胶囊联合复方麻黄碱色甘酸钠膜治疗变应性鼻炎疗效及其对血清炎性因子影响

洪超群¹，吴亚庆¹，吕政纲¹，程可佳²

¹浙江省东阳市人民医院耳鼻咽喉科，东阳 322100，浙江； ²浙江大学医学院附属第一医院鼻咽喉科，杭州 310003，浙江

收稿日期:2016-11-09 修回日期:2016-12-02 出版日期:2017-02-26 发布日期:2017-03-02
作者简介:洪超群，男，本科，主治医师，研究方向：鼾症治疗。 Tel：0578-86856141 E-mail：qpk1026@163.com
基金资助:
浙江省医药卫生一般研究计划（2013KYB112）

Effects of triprolidine tydrochloride capsules combined with compound ephedrine hydrochloride and cromolyn sodium pellicles on treating allergic rhinitis

HONG Chaoqun ¹，WU Yaqing ¹，LV Zhenggang¹，CHENG Kejia ²

¹Department of ENT, Dongyang People's Hospital，Dongyang 322100, Zhejiang, China；²Department of ENT，the First Affiliated Hospital of Zhejiang University Medical College, Hanghzou 310003, Zhejiang, China

Received:2016-11-09 Revised:2016-12-02 Online:2017-02-26 Published:2017-03-02

摘要/Abstract

摘要：

目的:研究曲普利啶胶囊联合复方麻黄碱色甘酸钠膜治疗变应性鼻炎（allergic rhinitis，AR）的临床疗效及其对患者血清炎性因子的影响。方法: 将2015年5月至2016年5月本院收治的106例AR患者作为研究对象，随机分为对照组和观察组，每组53例。对照组患者给予复方麻黄碱色甘酸钠膜治疗，观察组在对照组基础上另给予曲普利啶胶囊治疗。观察两组患者治疗效果，鼻痒、鼻塞、喷嚏、流涕及头痛等症状消失的时间。治疗前后分别检测两组患者血清肿瘤坏死因子α（TNF-α）、白细胞介素17（IL-17）、白细胞介素13（IL-13）、白细胞介素8（IL-8）及白细胞介素4（IL-4）等炎性因子含量；观察两组患者不良反应情况。结果: 观察组总有效率为92.5%，明显高于对照组的79.2%（P<0.05）；观察组鼻痒、鼻塞、喷嚏、流涕及头痛等症状消失的时间分别为（1.61±0.22）、（1.83±0.26）、（4.34±0.54）、（2.37±0.24）、（1.51±0.19）d，均明显短于对照组（P<0.05）；治疗后，观察组患者血清TNF-α、IL-17、IL-4、IL-8及IL-13含量分别为（0.83±0.22）、（43.15±5.21）、（35.42±10.65）、（113.12±18.53）、（5.44±1.05）ng/mL，均明显低于对照组（P<0.05）。治疗期间所有患者均未发生严重不良反应，两组不良反应发生率基本一致（P>0.05）。结论:曲普利啶胶囊联合复方麻黄碱色甘酸钠膜治疗AR疗效确切，具有深入研究的价值。

关键词: 变应性鼻炎, 曲普利啶胶囊, 复方麻黄碱色甘酸钠膜, 炎性因子

Abstract:

AIM: To study the effects of triprolidine hydrochloride capsules combined with compound ephedrine hydrochloride and cromolyn sodium pellicles on treating allergic rhinitis and its influence on the levels of inflammatory factors. METHODS: 106 patients with allergic rhinitis were collected and were randomly divided into control group and observation group (53 cases each). The control group was given compound ephedrine hydrochloride and cromolyn sodium pellicles, while the observation group was administered with extra triprolidine hydrochloride capsules. The curative effect of allergic rhinitis, disappearance time of related symptoms (nasal itching, nasal congestion, sneezing, runny nose and headache), the levels of inflammatory factors (TNF-α, IL-17, IL-4, IL-8 and IL-13) and the adverse actions were observed and compared. RESULTS:The total effective rate of observation group was 92.5%, which was significantly better than that of control group (79.2%). The nasal itching, nasal congestion, sneezing, runny nose and headache disappeared time in observation group were (1.61±0.22) d, (1.83±0.26) d, (4.34±0.54) d, (2.37±0.24) d and (1.51±0.19) d, respectively, which were significantly shorter than those of the control group (P<0.05). Levels of TNF-α, IL-17, IL-4, IL-8 and IL-13 were (0.83±0.22) ng/mL, (43.15±5.21) ng/mL, (35.42±10.65) ng/mL, (113.12±18.53) ng/mL and (5.44±1.05) ng/mL, which were significantly lower than those of the control group (P<0.05). No significant difference was observed in adverse actions between the two groups. CONCLUSION:Triprolidine hydrochloride capsules combined with compound ephedrine hydrochloride and cromolyn sodium pellicles on treating allergic rhinitis can improve the therapeutic effect, which is worthy of further study.

Key words: allergic rhinitis, triprolidine hydrochloride capsules, compound ephedrine hydrochloride and cromolyn sodium pellicles, inflammatory factors

中图分类号:

R765.21

洪超群，吴亚庆，吕政纲, 程可佳. 曲普利啶胶囊联合复方麻黄碱色甘酸钠膜治疗变应性鼻炎疗效及其对血清炎性因子影响[J]. 中国临床药理学与治疗学, 2017, 22(2): 160-164.

HONG Chaoqun，WU Yaqing，LV Zhenggang，CHENG Kejia. Effects of triprolidine tydrochloride capsules combined with compound ephedrine hydrochloride and cromolyn sodium pellicles on treating allergic rhinitis[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2017, 22(2): 160-164.

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