新生儿颅内出血患儿血清IL-6、TNF-α变化的临床研究

doi:10.11852/zgetbjzz2014-22-07-21

中国儿童保健杂志 ›› 2014, Vol. 22 ›› Issue (7): 733-734.DOI: 10.11852/zgetbjzz2014-22-07-21

新生儿颅内出血患儿血清IL-6、TNF-α变化的临床研究

刘艳红¹, 赵先锋², 贾美云¹, 闫安平¹

1 郑州人民医院新生儿科, 河南郑州 450000;
2 河南省人民医院心血管病医院二病区, 河南郑州 450000

收稿日期:2013-12-02 发布日期:2014-07-10 出版日期:2014-07-10
通讯作者: 闫安平, E-mail:lyhzwx@163.com
作者简介:刘艳红(1972-), 女, 副主任医师, 硕士学位, 主要研究方向为新生儿。

Clinical analysis on the levels of IL-6 and TNF-α in blood plasma of neonates with intracranial haemorrhage.

LIU Yan-hong¹, ZHAO Xian-feng², JIA Mei-yun¹, YAN An-ping¹

1 Department of Neonatology, Zhengzhou People's Hospital, Zhengzhou, Henan 450000, China;
2 Department of Internal Medicine, Henan Provincial Cardiovascular Hospital, Henan Provincial People's Hospital, Zhengzhou, Henan 450000, China

Received:2013-12-02 Online:2014-07-10 Published:2014-07-10
Contact: YAN An-ping, E-mail:lyhzwx@163.com

摘要/Abstract

摘要： 目的研究颅内出血足月新生儿血清中白介素-6(IL-6)、及肿瘤坏死因子-α(TNF-α)的变化及其临床意义。方法用ELISA法测定50例颅内出血足月新生儿和26例健康新生儿的血清 IL-6、TNF-α水平的变化。结果颅内出血足月新生儿血清IL-6、TNF-α水平明显升高, 与对照组比较, 差异有统计学意义(P＜0.05);IL-6、TNF-α水平在不同出血量组之间IL-6、TNF-α比较, 差异有统计学意义(P＜0.05);IL-6、TNF-α水平在不同出血量组部位之间IL-6、TNF-α比较, 差异无统计学意义(P＞0.05)。结论颅内出血足月新生儿血清IL-6、TNF-α水平明显增高, 可作为判断病情和评估预后的指标。

关键词: 颅内出血, 白介素-6, 肿瘤坏死因子-α, 新生儿

Abstract: Objective To explore the changes and clinical significance of serum levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in newborns with intracranial hemorrhage. Method The levels of IL-6 and TNF-α blood plasma in 50 neonates with intracranial haemorrhage (case group) and 26 healthy neonates (control group) were detected by ELISA. Results The levels of IL-6 and TNF-α in case group were significantly higher than those in control group (P<0.05);There were significant differences in levels of IL-6 and TNF-α between different amounts of bleeding group (P<0.05). Conclusions Serum levels of IL-6 and TNF-α creases obviously in newborns with intracranial hemorrhage, suggesting that they might be used as reference index in assessing pathogenetic condition and appraising prognosis.

Key words: intracranial haemorrhage, interleukin-6, tumor necrosis factor-α, neonates

中图分类号:

R722.1

刘艳红, 赵先锋, 贾美云, 闫安平. 新生儿颅内出血患儿血清IL-6、TNF-α变化的临床研究[J]. 中国儿童保健杂志, 2014, 22(7): 733-734.

LIU Yan-hong, ZHAO Xian-feng, JIA Mei-yun, YAN An-ping. Clinical analysis on the levels of IL-6 and TNF-α in blood plasma of neonates with intracranial haemorrhage.[J]. journal1, 2014, 22(7): 733-734.

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新生儿颅内出血患儿血清IL-6、TNF-α变化的临床研究

Clinical analysis on the levels of IL-6 and TNF-α in blood plasma of neonates with intracranial haemorrhage.

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