婴幼儿毛细支气管炎发展为哮喘的免疫机制研究进展

doi:10.11852/zgetbjzz2017-25-10-14

中国儿童保健杂志 ›› 2017, Vol. 25 ›› Issue (10): 1027-1029.DOI: 10.11852/zgetbjzz2017-25-10-14

婴幼儿毛细支气管炎发展为哮喘的免疫机制研究进展

智玉萍¹,何学明²,董青³

蚌埠医学院附属连云港东方医院 1儿科,2心内科,3新生儿科,江苏连云港 222042

收稿日期:2016-11-05 发布日期:2017-10-10 出版日期:2017-10-10
通讯作者: 董青,E-mail:dqshmu@sina.com
作者简介:智玉萍(1989-),女,山东人,研究生,硕士学位,主要研究方向为儿内科呼吸系统。
基金资助:
蚌埠医学院创新课题(Byycx1516)

Advances in the research of the immune mechanism of asthma in infants with bronchiolitis

ZHI Yu-ping¹,HE Xue-ming²,DONG Qing³

1 Department of Pediatrics;
2Department of Cardiology;
3 Department of Newborn,Lianyungang Oriental Hospital Affiliated to Bengbu Medical College,Lianyungang,Jiangsu 222042,China

Received:2016-11-05 Online:2017-10-10 Published:2017-10-10
Contact: DONG Qing,E-mail:dqshmu@sina.com

摘要/Abstract

摘要： 毛细支气管炎是婴幼儿住院的一个重要原因,属于一种婴幼儿较常见的下呼吸道感染,通常被认为是哮喘的第一次发作,与哮喘有着密切的关系,但其主要机制仍不清楚。近年来婴幼儿毛细支气管炎转变为哮喘的机制有较大进展,主要集中在免疫学领域。本文就近年免疫学方面的进展进行综述,以期为基础研究和临床诊疗提供参考。

关键词: 毛细支气管炎, 哮喘, 免疫, 细胞因子

Abstract: Bronchiolitis,a common lower respiratory tract infection in infants,is a major cause of infant hospitalization.Also,bronchiolitis is often considered the first attack of asthma,and has a close relationship with asthma,but its mechanism is still not clear.In recent years,the change of capillary bronchitis in infants and young children has a great progress,mainly in the field of immunology.This article reviews the progress of imm-unology in recent years,in order to provide reference for basic research and clinical diagnosis and treatment.

Key words: bronchiolitis, asthma, immune, cell factor

中图分类号:

R179

智玉萍,何学明,董青. 婴幼儿毛细支气管炎发展为哮喘的免疫机制研究进展[J]. 中国儿童保健杂志, 2017, 25(10): 1027-1029.

ZHI Yu-ping,HE Xue-ming,DONG Qing. Advances in the research of the immune mechanism of asthma in infants with bronchiolitis[J]. journal1, 2017, 25(10): 1027-1029.

0
/ / 推荐

导出引用管理器 EndNote|Ris|BibTeX

链接本文: https://manu41.magtech.com.cn/Jwk_zgetbjzz/CN/10.11852/zgetbjzz2017-25-10-14

https://manu41.magtech.com.cn/Jwk_zgetbjzz/CN/Y2017/V25/I10/1027

参考文献

[1] Midulla F,Pierangeli A,Cangiano G,et al.Rhinovirus bionchiolitis and recurrent wheezing:1-year follow-up[J].Eur respir,2012,39(2):396-402.
[2] Omari K E,Dhaliwal B,Ren J,et al.Structures of respiratory syncytial virus nucleocapsid protein from two crystal forms:details of potential packing interactions in the native helical form[J].Acta Crystallogr Sect F Struct Biol Cryst Commun,2011,67(10):1179-1183.
[3] 宋文秀,何月贤,赵维笑.LTC4S基因多态性与呼吸道合胞病毒毛细支气管炎的相关性[J].广东医学,2015,36(9):1380-1383.
[4] 顾坚,雷尚兵,张仕超,等.干扰素联合雾化吸入对毛细支气管炎患儿肺功能的影响[J].浙江临床医学,2014,16(5):735-736.
[5] Carbonellestrany X,Simes EA,Dagan R,et al.Motavizumab for prophylaxis of respiratory syncytial virus in high-risk children:a noninferiority trial [J].Pediatrics,2010,125(1):e35-e51.
[6] 周晓英.孟鲁司特钠治疗婴幼儿毛细支气管炎的疗效及对反复喘息的预防效果[J].中国临床药学杂志,2011(3):157-159.
[7] Han RF,Li HY,Wang JW,et al.Study on clinical effect and immunologic mechanism of infants capillary bronchitis secondary bronchial asthma treated with bacterial lysates Broncho-Vaxom[J].Eur Rev Med Pharmaco,2016,20(10):2151-2155.
[8] 平雯,章建伟,钟永兴.孟鲁司特钠对毛细支气管炎后喘息的治疗及预防作用[J].中国现代医生,2013,51(25):156-157.
[9] Zaid AN,Abualhasan MN,Watson DG,et al.Investigation of the bioequivalence of montelukast chewable tablets after a single oral administration using a validated LC-MS/MS method[J].Drug Des Devel Ther,2015,23(9):5315-5321.
[10] O'Shea JJ,Plenge R.JAK and STAT signaling molecules in immunoregulation and immune-mediated disease[J].Immunity,2012,36(4):542-550.
[11] Wang J,Wu J,Kong L,et al.BuShenYiQi Formula strengthens Th1 response and suppresses Th2-Th17 responses in RSV-induced asthma exacerbated mice[J].J Ethnopharmacol,2014,154(1):131-147.
[12] Zhang G,Zhou KF,Lu ZH.Interleukin-17 enhances the removal of respiratory syncytial virus in mice by promoting neutrophill migration and reducing interferon-gamma expression[J].Genet Mol Res,2016,15(1).doi:10.4238/gmr.15017002
[13] Mukherjee S,Lindell DM,Berlin AA,et al.IL-17-induced pulmonary pathogenesis during respiratory viral infection and exacerbation of allergic disease[J].Am J Pathol,2011,179(1):248-258.
[14] Cautivo KM,Bueno SM,Cortes CM,et al.Efficient lung recruitment of respiratory syncytial virus-specific Th1 cells induced by recombinant bacillus Calmette-Guérin promotes virus clearance and protects from infection [J].J Immunol,2010,185(12):7633-7645. [15] Faber TE,Groen H,Welfing M,et al.Specific increase in local IL-17 production during recovery from primary RSV bronchiolitis[J].J Med Virol,2012,84(7):1084-1088.
[16] Bystrom J,Amin K,Bishop-Bailey D.Analysing the eosinophil cationic protein-a clue to the function of the eosinophil granulocyte[J].Respiratory Research,2011,12(1):1-20.
[17] Choi J,Callaway Z,Kim HB,et al.The role of TNF-α in eosinophilic inflammation associated with RSV bronchiolitis [J].Pediatric Allergy & Immunology,2010,21(3):474-479.

婴幼儿毛细支气管炎发展为哮喘的免疫机制研究进展

Advances in the research of the immune mechanism of asthma in infants with bronchiolitis

PDF

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	刘佳敏, 赵莎, 钟燕. 外泌体与儿童神经精神障碍的研究进展[J]. 中国儿童保健杂志, 2023, 31(5): 521-525.
[2]	郑亭玉, 张春宇, 杨飞, 郑芳, 张梦霞, 夏露萍, 徐孙超. 营养支持小组管理模式对早产儿生长发育及免疫功能的影响[J]. 中国儿童保健杂志, 2023, 31(5): 555-558.
[3]	买国华. 学龄期支气管哮喘患儿自我管理行为调查及影响因素[J]. 中国儿童保健杂志, 2023, 31(4): 446-450.
[4]	翁婷婷, 高国朋, 王琼瑶, 谢亮亮, 李春刚, 严双琴, 陶芳标. 不同时点过敏暴露与儿童神经心理发育队列研究[J]. 中国儿童保健杂志, 2023, 31(2): 126-130.
[5]	李玉, 赵嘉虹, 阚璇. 中国儿童哮喘行动计划的临床应用研究[J]. 中国儿童保健杂志, 2023, 31(2): 185-189.
[6]	王旭, 王书影, 黎历, 邹映雪. 毛细支气管炎后复发喘息危险因素的Meta分析[J]. 中国儿童保健杂志, 2023, 31(2): 190-194.
[7]	杨茹莱. 原发性免疫缺陷病和脊髓性肌萎缩症临床特点及新生儿早期联合筛查实践[J]. 中国儿童保健杂志, 2022, 30(7): 697-701.
[8]	王珊, 何学佳, 成翕悦, 林烨, 裴培, 占小俊. 维甲酸诱导小鼠神经管畸形胚脑中H2BK120ub1的全基因组状态变化[J]. 中国儿童保健杂志, 2022, 30(7): 731-736.
[9]	徐燕, 刘东海, 梁譞, 郭丽, 戴永利, 张蓉芳. 高原地区儿童哮喘影响因素分析[J]. 中国儿童保健杂志, 2022, 30(7): 796-800.
[10]	谢姝, 刘瑜, 李德欣, 李玲, 邹明扬, 孙彩虹. 内源性大麻素系统对孤独症谱系障碍异常神经炎症反应调控作用的研究进展[J]. 中国儿童保健杂志, 2022, 30(4): 392-395.
[11]	张小玲, 刘秀梅. Tourette综合征的免疫病理机制研究进展[J]. 中国儿童保健杂志, 2022, 30(4): 409-412.
[12]	张瑜, 谢小敏, 马田, 仝海霞, 王蕾, 李鸽, 于夏, 尚磊, 江逊. 青春期哮喘患儿疾病控制与家庭功能、自我管理、知觉压力的相关性研究[J]. 中国儿童保健杂志, 2022, 30(3): 314-318.
[13]	陶凤姣, 温航卫, 刘作姣. 毛细支气管炎患儿血清高迁移率族蛋白B₁、可溶性清道夫受体163水平与呼出气一氧化氮浓度及病情严重程度的关系[J]. 中国儿童保健杂志, 2022, 30(3): 335-338.
[14]	李玉, 阚璇. 细菌溶解产物在儿童呼吸道过敏性疾病应用的研究进展[J]. 中国儿童保健杂志, 2022, 30(12): 1336-1340.
[15]	张洋, 王慧渊, 耿妍, 金巧艳, 郝娟娟, 侯伟. 支气管哮喘儿童情绪问题现状及相关因素分析[J]. 中国儿童保健杂志, 2022, 30(12): 1400-1403.