关键词: 外源性肺表面活性物质, 新生儿呼吸窘迫综合征, 免疫功能, 新生儿

Abstract: Objective To investigate the effects of exogenous pulmonary surfactant (PS) on immune function in infants with neonatal respiratory distress syndrome (NRDS),and to explore new usage of exogenous pulmonary surfactant,in order to provide new evidence and theoretical basis for prevention and treatment of neonatal respiratory distress syndrome. Method Totally 61 patients with neonatal respiratory distress syndrome were selected as the research objects. Thirty patients treated with PS were selected as the observation group, while 31 infants received no PS replacement therapy as the control group. The levels of immunoglobulin,complement and lymphocyte subtypes were measured before and after treatment in both groups. Results After treatment,the level of IgG in patients with NRDS in observation group did not significantly decrease(P>0.05),while B lymphocytes and natural killer(NK) cell increased significantly (P<0.05). However,there were no significant difference on serum IgA,IgM,complement C3,C4,Th and Ts leukomonocyte before and after treatment in the two groups(P>0.05). Conclusion Exogenous PS can improve immune function in infant with neonatal respiratory distress syndrome,and it may play a certain role in improving the therapeutic effect.

Key words: exogenous pulmonary surfactant, neonatal respiratory distress syndrome, immune function, neonates