关键词: 妊娠合并甲状腺功能减退症, 促甲状腺激素, 先天性甲状腺功能减退症, 新生儿

Abstract: Objective To analyze the effect of hypothyroidism in pregnancy on thyroid stimulating hormone (TSH) of heel blood in neonates. Methods A total of 191 neonates delivered by pregnant women with hypothyroidism were enrolled in case group, and 9 839 neonates delivered by healthy pregnant women were collected as control group from April 2015 to April 2017.Neonates′ heel blood was collected, and blood levels of TSH were measured.The concomitant variables of neonatal heel blood TSH were screened by univariate analysis, and the effect of hypothyroidism in pregnancy on neonatal TSH level was assessed by multiple linear regression. Results The level of TSH in neonates was associated with maternal age, gestational age, blood collection time after birth, gender and hypothyroidism in pregnancy.The false positive rate of congenital hypothyroidism (CH) screening in neonates delivered by pregnant women with hypothyroidism increased to 4.19% notably.Multifactor analysis showed that hypothyroidism in pregnancy was a risk factor for TSH level increase in neonatal heel blood (β=0.78,95% CI:0.42~1.14,P<0.001). Conclusion Hypothyroidism in pregnancy is a risk factor for TSH level increase in neonatal heel blood, and it may increase the false positive rate of CH screening in neonates.

Key words: hypothyroidism in pregnancy, thyroid stimulating hormone, congenital hypothyroidism, neonates