不同糖耐量肥胖儿童血清硫化氢及25-羟基维生素D3水平变化研究

doi:10.11852/zgetbjzz2018-26-09-08

中国儿童保健杂志 ›› 2018, Vol. 26 ›› Issue (9): 956-959.DOI: 10.11852/zgetbjzz2018-26-09-08

不同糖耐量肥胖儿童血清硫化氢及25-羟基维生素D₃水平变化研究

张远达¹,刘毓²,张瑜¹,刘瑞花³,柏璐⁴,董青伟¹,宋浩斌¹,韩立坡¹

1 保定市儿童医院,保定市儿童呼吸消化疾病临床研究重点实验室,河北保定 071000;
2 贵阳市儿童医院,贵州贵阳 550003;
3 济宁医学院附属医院,山东济宁 272000;
4 河北省儿童医院儿童,河北石家庄 050031

收稿日期:2017-08-30 发布日期:2018-09-10 出版日期:2018-09-10
通讯作者: 刘毓,E-mial:liuyu420@189.cn
作者简介:张远达(1984-),男,河北人,主治医师,本科学历,主要研究方向为小儿内分泌及消化系统疾病。
基金资助:
河北省科技计划项目(172777129); 保定市科技支撑计划项目(17ZF062)

Study on hydrogen sulfide and 25-(OH)D₃ in obese children with different glucose tolerance

ZHANG Yuan-da¹, LIU Yu², ZHANG Yu¹, LIU Rui-hua³, BAI Lu⁴,DONG Qing-wei¹, SONG Hao-bin¹,HAN Li-po¹

1 Baoding Children's Hospital,Baoding, Hebei 071000,China;
2 Guiyang Children's Hospital,Guiyang,Guizhou 550003,China;
3 Affiliated Hospital of Jining Medical University,Jining,Shandong 272000,China;
4 Hebei Province Children's Hospital,Shijiazhuang,Hebei 050031,China

Received:2017-08-30 Online:2018-09-10 Published:2018-09-10
Contact: LIU Yu,E-mail:liuyu420@189.cn

摘要/Abstract

摘要： 目的研究不同糖耐量肥胖儿童血清硫化氢(H₂S)及25-羟基维生素D₃[25-(OH)D₃]水平的变化及意义,为临床治疗提供参考依据。方法 2013年1月-2016年1月收集204例口服葡萄糖耐量试验(OGTT)结果异常肥胖儿童的资料,根据OGTT结果将其分为空腹血糖受损(IFG)组、糖耐量受损(IGT)组、IFG合并IGT组以及糖尿病(DM)组。选择同期46例OGTT正常的肥胖儿童为单纯肥胖组,分别通过分光光度计法检测H₂S水平,酶联免疫法检测25-(OH)D₃水平。结果 IFG组、IGT组、IFG合并IGT组以及DM组血清H₂S及25-(OH)D₃水平均低于单纯肥胖组(P＜0.05);IFG合并IGT组血清H₂S及25-(OH)D₃均低于IFG组、IGT组(P＜0.05);DM组血清H₂S及25-(OH)D₃水平均低于IFG组、IGT组及IFG合并IGT组(P＜0.05);IFG组血清H₂S低于IGT组(P＜0.05)。DM组血清H₂S及25-(OH)D₃水平均低于单纯肥胖组(P＜0.05);IFG合并IGT组血清H₂S及25-(OH)D₃水平均低于单纯肥胖组(P＜0.05)。相关性分析中,单纯肥胖组、IFG组、IGT组、IFG合并IGT组以及DM组血清H₂S及25-(OH)D₃与0 h PG、2 h PG、HBALC水平均呈显著性负相关(all P＜0.05);单纯肥胖组、IFG组、IGT组、IFG合并IGT组以及DM组血清H₂S与25-(OH)D₃水平与呈显著正相关( P＜0.05)。结论血清H₂S及25-(OH)D₃水平与肥胖儿童糖耐量情况密切相关,其水平的明显下降可能是肥胖儿童发展为2型糖尿病的危险因素。

关键词: 2型糖尿病, 硫化氢, 25-羟基维生素D₃

Abstract: Objective To study the significance of changes of serum hydrogen sulfide and 25-(OH)D₃ in obese children with different glucose tolerance. Methods According to the oral glucose tolerance test(OGTT),204 obese children were divided into impaired fasting glycaemia(IFG) group,impaired glucose tolerance (IGT) group,IFG combined with IGT group and diabetes mellitus(DM) group from Jan 2013 to Jan 2016. Totally 46 obese children with normal OGTT were as obese group. The levels of serum H₂S and 25-(OH)D₃ were tested by spectrophotometer and euzymelinked immunosorbent assay(ELISA) respectively. Results The levels of H₂S and 25-(OH)D₃ were lowest in obese group (P＜0.05);The levels of H₂S and 25-(OH)D₃ were lower in IFG combined with IGT group than IFG group and IGT group (P＜0.05);The levels of H₂S and 25-(OH)D₃ were lower in DM group than those of IFG group,IGT group and IFG combined with IGT group(P＜0.05); The levels of H₂S and 25-(OH)D₃ were lower in IFG group than IGT group(P＜0.05). The levels of H₂S and 25-(OH)D₃ were lower in DM group than obese group (P＜0.05); The levels of H₂S and 25-(OH)D₃ were lower in IFG combined with IGT group than obese group and IGT group (P＜0.05).The levels of serum H₂S and 25-(OH)D₃ was negatively correlated with 0 h PG,2 h PG and HBALC (P<0.05). The level of serum H₂S was positively correlated with 25-(OH)D₃(P<0.05). Conclusion Serum levels of H₂S and 25-(OH)D₃ are closely associated with glucose tolerance in obese children and it may develop into a risk factor when the levels decrease obviously.

Key words: diabetes mellitus type 2, H₂S, 25-(OH)D₃

中图分类号:

R179

张远达,刘毓,张瑜,刘瑞花,柏璐,董青伟,宋浩斌,韩立坡. 不同糖耐量肥胖儿童血清硫化氢及25-羟基维生素D₃水平变化研究[J]. 中国儿童保健杂志, 2018, 26(9): 956-959.

ZHANG Yuan-da, LIU Yu, ZHANG Yu, LIU Rui-hua, BAI Lu,DONG Qing-wei, SONG Hao-bin,HAN Li-po. Study on hydrogen sulfide and 25-(OH)D₃ in obese children with different glucose tolerance[J]. journal1, 2018, 26(9): 956-959.

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不同糖耐量肥胖儿童血清硫化氢及25-羟基维生素D₃水平变化研究

Study on hydrogen sulfide and 25-(OH)D₃ in obese children with different glucose tolerance

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