关键词: 钙, 身长, 25羟维生素D, 骨密度

Abstract: Objective To investigate the correlation of calcium and vitamin D levels with body length development of 2- to 3-year-old children, so as to provide theoretical basis for the intervention of physical development deviation. Methods A retrospective analysis was performed on the clinical data of 204 children aged 2 to 3 years who underwent routine physical examination in the Department of Child Health of Northwest Women and Children's Hospital from September 2019 to June 2021.Standard physical measurements and previous calcium and vitamin D supplementation were collected retrospectively in the form of a questionnaire, and serum 25-(OH) D level and bone mineral density were measured. Spearman correlation and Logistic multifactor regression analysis were used to analyze the correlation of calcium and vitamin D levels with physical development. Results The median daily dose of vitamin D supplementation was 569.5 U, and the median of serum 25-(OH)D was 35.60 ng/dl in 204 children. The deficiency, insufficiency, sufficiency rates of vitamin D were 1.96%, 0.98% and 97.06%, respectively. No children took in excessive vitamin D. The median bone mineral density(BMD) was P64.0. Univariate Spearman rank correlation analysis indicated that the daily average supplementation doses of vitamin D and calcium were both positively correlated with body length(r=0.172, 0.213, P<0.05), while the bone mineral density was negatively correlated with body length(r=-0.138, P<0.05). Multivariate Logistic regression analysis showed that the average daily calcium supplementation dose was positively correlated with body length, with statistical significance(OR=1.003, 95%CI:1.001 - 1.006, P<0.05), while daily vitamin D supplementation dose and bone mineral density were not found to be significantly related to body length. Conclusion Continuous supplementation of calcium can promote the body length development of 2- to 3-year-old children.

Key words: calcium, body length, 25-hydroxyl vitamin D, bone mineral density