关键词: 骨钙素, 血清β胶原分解片段, 血清钙, 甲状旁腺素, 25-羟胆骨化醇, 新生儿

Abstract: 【Objective】 To explore characters of bone metabolism in neonates. 【Methods】 The concentrations of serum osteocalcin (OC), beta-crossLaps (β-CTx), calcium, parathyroid hormone (PTH) and 25-hydroxycholecalciferol [25(OH)D₃] were measured in 30 appropriate for gestational age(AGA) term infants, 17 small for gestational age(SGA) term infants, 33 AGA preterm infants and 6 SGA preterm infants, and the data were statistically analyzed. 【Results】 The concentrations of serum OC in group of SGA term infant and AGA preterm infants were less than that in group of AGA term infant(P<0.05); The concentrations of serum β-CTx in group of AGA term infant was less than that in group of AGA preterm infant(P<0.05); The concentrations of serum calcium in group of SGA and AGA preterm infant was less than that in group of AGA term infant(P<0.05); The concentrations of serum PTH in group of AGA preterm infant was less than that in group of AGA and SGA term infant(P<0.05); The concentrations of serum 25(OH)D₃ had no statistical difference in group of AGA term infant 、SGA term infant、AGA preterm infant and SGA preterm infant(P>0.05). 【Conclusions】 The SGA term infant, AGA and SGA preterm infant easily occur metabolic bone diseases, the supervisal in metabolic bone diseases for them should be strengthened, and Vitamin D difficiency rickets in AGA term infant should be paid attention to supervise too.

Key words: osteocalcin, serum beta-crossLaps, serum calcium, parathyroid hormone, 25-hydroxycholecalciferol, neonates