关键词: 母乳, 唾液酸, 新生儿

Abstract: Objective To study the sialic acid (SA) levels in breast milk collected from early neonate's mother, and provide the scientific basis for early breast-milk feeding in neonate especially in pre-term neonates. Methods A total of 284 breast milk samples were collected from 122 early neonate's mothers at the 1^st, 4^th and 6^th days after delivery.The SA levels in breast milk were tested with neuraminidase assay method, the statistical analysis software, SPSS version 17.0 was used in the study.Independent sample T test was used to compare SA levels between groups and Pearson correlation analysis method was used to analyze correlation. Results The mean SA levels in the 1^st day breast milk was (208.6±71.6)mg/dL, which was significantly higher than that in the 4^th day breast milk [(140.4±36.6) mg/dL;t=8.100, P<0.001] and the 6^th day breast milk [(139.3±37.8) mg/dL;t=8.089, P<0.001], however, no difference was found between the 4^th day and 6^th day breast milk(t=0.197, P=0.844).A strong negative correlation between SA levels in breast milk and days after delivery in women was identified, however, no correlation was found between SA levels and birth weights or gestational ages. Conclusion The SA levels is the highest in the 1^st day breast milk and SA levels in brest milk are strongly correlated with the days after delivery in women.

Key words: breast milk, sialic acid, neonate