生长激素缺乏症患儿IGF-1与体质量指数的相关研究

doi:10.11852/zgetbjzz2018-26-01-05

中国儿童保健杂志 ›› 2018, Vol. 26 ›› Issue (1): 15-18.DOI: 10.11852/zgetbjzz2018-26-01-05

生长激素缺乏症患儿IGF-1与体质量指数的相关研究

王盼盼¹, 张梅², 李萍², 孙海玲², 晏文华², 邵倩², 班博²

1 济宁医学院,山东济宁 272067
2 济宁医学院附属医院内分泌科,山东济宁 272029

收稿日期:2017-07-04 发布日期:2018-01-10 出版日期:2018-01-10
通讯作者: 班博,E-mail:banbo2011@163.com
作者简介:王盼盼 (1990), 女, 山东人, 硕士研究生, 主要研究方向为下丘脑垂体疾病。
基金资助:
山东省自然科学基金培养基金项目(ZR2014HP058)

Study on the correlation of IGF-1 levels and body mass index in children with growth hormone deficiency

WANG Pan-pan¹, ZHANG Mei², LI Ping², SUN Hai-ling², YAN Wen-hua², SHAO Qian², BAN Bo²

1 Jining Medical University,Jining,Shandong 272067,China
2 Department of Endocrinology,Affiliated Hospital of Jining Medical University,Jining,Shandong 272029,China

Received:2017-07-04 Online:2018-01-10 Published:2018-01-10
Contact: BAN Bo,E-mail:banbo2011@163.com

摘要/Abstract

摘要： 目的分析生长激素缺乏症(GHD)患儿的胰岛素样生长因子-1(IGF-1)与体质量指数(BMI)水平的关系。方法回顾性分析137例GHD患儿的临床资料,每例均收集其身高(Ht)、体重(Wt)、BMI、血清生长激素(GH)、血清IGF-1等指标。结果 1)GHD患儿中IGF-1水平与BMI呈正相关;2)GHD患儿IGF-1水平受性别、BMI、青春期状态等因素的影响;3)GHD患儿中,在BMI SDS＜0.30组,BMI SDS每增加1个单位,IGF-1 SDS降低2%,差异无统计学意义(P>0.05);在BMI SDS≥0.30组,BMI SDS每增加1个单位,IGF-1 SDS增加93%,差异具有统计学意义(P<0.001);4)调整了性别、血小板、天门冬氨酸氨基转移酶、肌酐、高密度脂蛋白、促黄体生成素、促卵泡刺激素、雌二醇、睾酮、骨龄落后程度等混杂因素后,青春期前GHD患儿的BMI SDS每增加1个单位,IGF-1 SDS增加39.3%;青春期GHD患儿的BMI SDS每增加1个单位,IGF-1 SDS降低98.8%,差异均具有统计学意义(P<0.001或<0.05)。结论 GHD患儿的IGF-1水平受性别、BMI、青春期状态等因素的影响,并且适宜的BMI有利于促进GHD患儿的生长发育。GHD患儿在青春期前应适当增加BMI,进入青春期后应注意控制其BMI,这可能有助于IGF-1维持在较高水平,从而有利于其生长发育。

关键词: 生长激素缺乏症, 体质量指数, IGF-1

Abstract: Objective To study the relationship between insulin-like growth factor-1 (IGF-1) and body mass index (BMI) in children with growth hormone deficiency (GHD). Methods The clinical data of 137 children with GHD were retrospectively analyzed.The data of body height (Ht),body weight (Wt),BMI,serum growth hormone (GH) and serum IGF-1 were collected. Results 1) The level of IGF-1 in children with GHD was positively correlated with BMI;2) The level of IGF-1 in children with GHD was influenced by factors such as sex,BMI,adolescent status and other factors;3) In the group of BMI SDS<0.30,IGF-1 SDS decreased significantly by 2% for per 1 unit increase of BMI SDS (P>0.05).In the BMI SDS≥0.30 group,IGF-1 SDS increased significantly by 93% for every 1 unit increase of BMI SDS (P<0.001);4) After adjusted for gender,platelet,aspartate aminotransferase,creatinine,high density lipoprotein,luteinizing hormone,follicle stimulating hormone,estradiol,testosterone,the level of IGF-1 SDS increased by 39.3% for per unit increase of BMI SDS in prepuberty children with GHD and decreased by 98.8% for per unit increase of BMI SDS in puberty children with GHD (P<0.001 or <0.05). Conclusions The level of IGF-1 in children with GHD is affected by factors such as sex,BMI,and adolescent status.Appropriate level of BMI can promote the growth and development of GHD children.GHD children should increase BMI appropriately at prepuberal stage,and control BMI at puberty,which may help maintain a high level of IGF-1 and facilitate its growth and development.

Key words: growth hormone deficiency, body mass index, IGF-1

中图分类号:

R179

王盼盼, 张梅, 李萍, 孙海玲, 晏文华, 邵倩, 班博. 生长激素缺乏症患儿IGF-1与体质量指数的相关研究[J]. 中国儿童保健杂志, 2018, 26(1): 15-18.

WANG Pan-pan, ZHANG Mei, LI Ping, SUN Hai-ling, YAN Wen-hua, SHAO Qian, BAN Bo. Study on the correlation of IGF-1 levels and body mass index in children with growth hormone deficiency[J]. journal1, 2018, 26(1): 15-18.

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生长激素缺乏症患儿IGF-1与体质量指数的相关研究

Study on the correlation of IGF-1 levels and body mass index in children with growth hormone deficiency

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