关键词: 早产儿视网膜病变, 高龄产妇, 孕产期因素

Abstract: Objective To analyze the correlation between pregnancy and prenatal risk factors and occurrence of retinopathy of prematurity(ROP),in order to provide scientific evidence for the prevention and treatment of ROP. Methods Premature infants with profiles,who were completed the RetCam 3 fundus examination in eye clinic of Hunan Provincial Maternal and Child Health Care Hospital from June 2016 to June 2017,were included.RetCam 3 fundus examination Results,gestational age,birth weight,maternal age,parity,pregnancy related diseases were recorded and analyzed statistically to explore the risk factors for ROP. Results A total of 1 956 cases of premature were included and 354 ROP patients were identified(18.10%).Logistic regress analysis indicated that gestational age ＜28 weeks(OR=21.649,95%CI:18.485-24.327),low birth body weight(<1 000 g)(OR=13.013,95%CI:10.861-16.233),fetal distress(OR=2.328,95%CI:1.269-3.156),gestational hypertension(OR=2.121,95%CI:1.072-3.571),gestational diabetes mellitus(OR=1.995,95%CI:1.008-2.929) were high-risk factors for the development of ROP in premature infants,while pregnant women age,parity and anemia during pregnancy were not significantly correlated with ROP(P＞0.05). Conclusion Factors including preterm infants with gestational age＜28 weeks and low birth body weight(<1 000 g),fetal distress,mother with gestational hypertension and gestational diabetes mellitus,are closely related to ROP.

Key words: retinopathy of prematurity, elderly parturient, pregnancy and maternal factors