围生期解脲支原体感染与不良孕产结局及新生儿疾病关联

doi:10.11852/zgetbjzz2022-1127

中国儿童保健杂志 ›› 2022, Vol. 30 ›› Issue (10): 1049-1052.DOI: 10.11852/zgetbjzz2022-1127

围生期解脲支原体感染与不良孕产结局及新生儿疾病关联

李秋平

中国人民解放军总医院儿科医学部,中国人民解放军总医院第七医学中心儿科,出生缺陷防控关键技术国家工程实验室,儿童器官功能衰竭北京市重点实验室,北京 100700

收稿日期:2022-09-12 修回日期:2022-09-14 发布日期:2022-10-14 出版日期:2022-10-10
作者简介:李秋平(1975-),男,江西人,主任医师,博士生导师,主要研究方向为新生儿疾病。
基金资助:
国家重点研发计划项目(2021YFC2701700)

Association of perinatal ureaplasma urealyticum infection with adverse pregnancy outcomes and neonatal related disorders

LI Qiu-ping

Faculty of Pediatrics, Chinese PLA General Hospital; Department of Pediatrics, 7th Medical Center of Chinese PLA General Hospital; National Engineering Laboratory for Birth Defects Prevention and Control of Key Technology; Beijing Key Laboratory of Pediatric Organ Failure, Beijing 100700, China

Received:2022-09-12 Revised:2022-09-14 Online:2022-10-10 Published:2022-10-14

摘要/Abstract

摘要： 围生期解脲支原体感染与不孕不育、胎膜早破、绒毛膜羊膜炎、流产、早产甚至死胎死产等不良妊娠结局及诸多新生儿期疾病存在关联。本文将重点阐述围生期解脲支原体感染的流行病学特点,围生期解脲支原体暴露与不良孕产结局,新生儿尤其是早产儿相关疾病如脓毒症、支气管肺发育不良、脑室内出血和坏死性小肠结肠炎等的关联,以及解脲支原体诊断和防治措施,为临床防治提供参考。

关键词: 围生期, 解脲支原体, 新生儿, 疾病

Abstract: Perinatal ureaplasma spp. infection is associated with adverse pregnancy outcomes such as infertility, premature rupture of membranes, chorioamnionitis, miscarriage, preterm delivery and even stillbirth, as well as many diseases in neonatal period. This paper will focus on the epidemiological characteristics of ureaplasma spp. infection in perinatal period, the association of ureaplasma spp. exposure with adverse pregnancy outcomes, neonatal and especially preterm related diseases such as sepsis, bronchopulmonary dysplasia, intraventricular hemorrhage and necrotizing enterocolitis, as well as the diagnosis and prevention measures of ureaplasma spp., so as to provide reference for the prevention and treatment of clinically relevant diseases.This paper will focus on the epidemiological characteristics of perinatal Mycoplasma solani infections, the association of perinatal Mycoplasma solani exposure with adverse maternal outcomes, neonatal and especially preterm related diseases such as sepsis, bronchopulmonary dysplasia, intraventricular hemorrhage and necrotizing small bowel colitis, and the diagnostic and preventive measures of Mycoplasma solani for clinical control.

Key words: perinatal period, urealyticum species, newborn, disease

中图分类号:

R714.25

李秋平. 围生期解脲支原体感染与不良孕产结局及新生儿疾病关联[J]. 中国儿童保健杂志, 2022, 30(10): 1049-1052.

LI Qiu-ping. Association of perinatal ureaplasma urealyticum infection with adverse pregnancy outcomes and neonatal related disorders[J]. Chinese Journal of Child Health Care, 2022, 30(10): 1049-1052.

参考文献

[1] Kacerovsky M, Kukla R, Bolehovska R, et al. Prevalence and load of cervical ureaplasma species with respect to intra-amniotic complications in women with preterm prelabor rupture of membranes before 34 weeks[J]. Front Pharmacol,2022,13: 860498.
[2] Plummer EL, Vodstrcil LA, Bodiyabadu K, et al. Are mycoplasma hominis, ureaplasma urealyticum and ureaplasma parvum associated with specific genital symptoms and clinical signs in nonpregnant women[J]. Clin Infect Dis,2021,73(4): 659-668.
[3] Sprong KE, Mabenge M, Wright CA, et al. Ureaplasma species and preterm birth: current perspectives[J]. Crit Rev Microbiol,2020,46(2): 169-181.
[4] Xu YP, Hu JM, Huang YQ, et al. Maternal ureaplasma exposure during pregnancy and the risk of preterm birth and BPD: A Meta-analysis[J]. Arch Gynecol Obstet,2022. doi: 10.1007/s00404-022-06491-7.
[5] Chu A, de St Maurice A, Sim MS, et al. Neonatal mycoplasma and ureaplasma infections[J]. Pediatr Ann,2020,49(7): e305-e312.
[6] Silwedel C, Speer CP, Glaser K. Ureaplasma-associated prenatal, perinatal, and neonatal morbidities[J]. Expert Rev Clin Immunol,2017,13(11): 1073-1087.
[7] Gupta A, Gupta A, Gupta S, et al. Correlation of mycoplasma with unexplained infertility[J]. Arch Gynecol Obstet,2009, 280(6):981-985.
[8] Zhou YH, Ma HX, Shi XX,et al.Ureaplasma spp. in male infertility and its relationship with semen quality and seminal plasma components[J]. J Microbiol Immunol Infect,2018,51(6):778-783.
[9] Jacobsson B,Aaltonen R,Rantakokko-Jalava K,et al.Quantification of Ureaplasma urealyticum DNA in the amniotic fluid from patients in PTL and pPROM and its relation to inflammatory cytokine levels[J]. Acta Obstet Gynecol Scand,2009,88(1):63-70.
[10] Rittenschober-Böhm J, Waldhoer T, Schulz SM, et al. Vaginal Ureaplasma parvum serovars and spontaneous preterm birth[J]. Am J Obstet Gynecol,2019,220(6): 594.
[11] Miyoshi Y, Suga S, Sugimi S, et al. Vaginal Ureaplasma urealyticum or Mycoplasma hominis and preterm delivery in women with threatened preterm labor[J]. J Matern Fetal Neonatal Med, 2022,35(5):878-883..
[12] Resch B, Gutmann C, Reiterer F, et al. Neonatal Ureaplasma urealyticum colonization increases pulmonary and cerebral morbidity despite treatment with macrolide antibiotics[J]. Infection,2016, 44(3):323.
[13] Ollikainen J, Hiekkaniemi H, Korppi M, et al. Ureaplasma urealyticum infection associated with acute respiratory insufficiency and death in premature infants[J]. J Pediatr,1993,122(5 Pt 1): 756-760.
[14] Yoder BA,Coalson JJ,Winter VT,et al.Effects of antenatal colonization with ureaplasma urealyticum on pulmonary disease in the immature baboon[J]. Pediatr Res,2003 ,54(6):797-807.
[15] Sung TJ, Xiao L, Duffy L, et al. Frequency of ureaplasma serovars in respiratory secretions of preterm infants at risk for bronchopulmonary dysplasia[J]. Pediatr Infect Dis J,2011,30(5):379-383.
[16] Viscardi RM. Ureaplasma species: role in neonatal morbidities and outcomes[J]. Arch Dis Child Fetal Neonatal Ed,2014,99(1): 87-92.
[17] Schelonka RL,Katz B,Waites KB,et al.Critical appraisal of the role of Ureaplasma in the development of bronchopulmonary dysplasia with metaanalytic techniques[J]. Pediatr Infect Dis J,2005 ,24(12):1033-1039.
[18] Wang EE, Ohlsson A, Kellner JD. Association of Ureaplasma urealyticum colonization with chronic lung disease of prematurity: results of a metaanalysis[J]. J Pediatr,1995,127(4): 640-644.
[19] Lowe J, Watkins WJ, Edwards MO, et al. Association between pulmonary ureaplasma colonization and bronchopulmonary dysplasia in preterm infants: updated systematic review and meta-analysis[J]. Pediatr Infect Dis J,2014,33(7):697-702.
[20] Goldenberg RL, Andrews WW, Goepfert AR, et al. The alabama preterm birth study: Umbilical cord blood ureaplasma urealyticum and mycoplasma hominis cultures in very preterm newborn infants[J]. Am J Obstet Gynecol,2008,198(1): 43.
[21] Milisavljevic V, Garg M, Vuletic I,et al. Prospective assessment of the gastroesophageal microbiome in VLBW neonates[J]. BMC Pediatr,2013, 13:49.
[22] Wolfs TG, Kallapur SG, Knox CL, et al. Antenatal ureaplasma infection impairs development of the fetal ovine gut in an IL-1-dependent manner[J]. Mucosal Immunol, 2013,6(3): 547-556.
[23] Okogbule-Wonodi A, Gross G, Sun CC,et al. Necrotizing enterocolitis is associated with ureaplasma colonization in preterm infants[J]. Pediatr Res,2011, 69(5pt1):442-447.
[24] Viscardi R, Hashmi N, GrossG, et al. Incidence of invasive Ureaplasma in VLBW infants: relationship to severe intraventricular hemorrhage[J]. J Perinatol,2008,28(11): 759-765.
[25] Kasper DC, Mechtler TP, Böhm J, et al. In utero exposure to Ureaplasma spp. is associated with increased rate of bronchopulmonary dysplasia and intraventricular hemorrhage in preterm infants[J]. J Perinat Med,2011,39(3):331-336.
[26] Viscardi RM. Ureaplasma species: role in diseases of prematurity[J]. Clin Perinatol,2010,37(2): 393-409.
[27] Berger A, Witt A, Haiden N, et al. Intrauterine infection with Ureaplasma species is associated with adverse neuromotor outcome at 1 and 2 years adjusted age in preterm infants[J]. J Perinat Med,2009,37(1):72-78.
[28] Shrivastava S, Methé BA, Inman J, et al. Comparative genome analysis of 19 Ureaplasma urealyticum and Ureaplasma parvum strains[J]. BMC Microbiol,2012, 12:88.
[29] Donders GGG, Ruban K, Bellen G, et al. Mycoplasma/ureaplasma infection in pregnancy:To screen or not to screen[J]. J Perinat Med,2017,45(5):505-515.
[30] Grigsby PL, Novy MJ, Sadowsky DW, et al. Maternal azithromycin therapy for Ureaplasma intraamniotic infection delays preterm delivery and reduces fetal lung injury in a primate model[J]. Am J Obstet Gynecol,2012,207(6): 475.
[31] Viscardi RM, Terrin ML, Magder LS, et al. Randomised trial of azithromycin to eradicate Ureaplasma in preterm infants[J]. Arch Dis Child Fetal Neonatal Ed,2020, 105(6): 615-622.
[32] Viscardi RM,Terrin ML,Magder LS,et al. Randomized trial of azithromycin to eradicate Ureaplasma respiratory colonization in preterm infants: 2-year outcomes[J]. Pediatric Res, 2022,91(1):178-187.

围生期解脲支原体感染与不良孕产结局及新生儿疾病关联

Association of perinatal ureaplasma urealyticum infection with adverse pregnancy outcomes and neonatal related disorders

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