中国儿童保健杂志 ›› 2014, Vol. 22 ›› Issue (8): 816-818.DOI: 10.11852/zgetbjzz2014-22-08-10

• 科研论著 • 上一篇    下一篇

小于胎龄儿学龄前期生长方式与胰岛素抵抗的相关性研究

赵奕怀, 杨曙晖, 陈倪, 周幼珊, 蔡琍璇, 林明祥   

  1. 中山大学附属汕头医院新生儿科, 广东 汕头 515000
  • 收稿日期:2013-10-28 发布日期:2014-08-10 出版日期:2014-08-10
  • 作者简介:赵奕怀(1972-), 女, 广东人, 主任医师, 本科学历, 主要研究方向为新生儿学。
  • 基金资助:
    汕头市重点科技计划项目[(2012)113-10]

Study on the association between growth pattern of preschool age and insulin resistance in small for gestaional age infants.

ZHAO Yi-huai, YANG Shu-hui, CHEN Ni, ZHOU You-shan, CAI Li-xuan, LIN Ming-xiang.   

  1. Department of Neonatology, Affiliated Shantou Hospital of SUN-Yatsen University, Shantou, Guangdong 515000, China
  • Received:2013-10-28 Online:2014-08-10 Published:2014-08-10

摘要: 目的 研究小于胎龄儿(small for gestaional age, SGA)生后至学龄前期生长方式与胰岛素抵抗的关系。方法 采用前瞻性研究方法, 分析68名SGA与42名适于胎龄儿(appropriate for gestaional age, AGA)生后3 d和4周岁时空腹血糖、胰岛素及稳态模型评估(HOMA-IR、HOMA-β)值, 以及SGA不同生长方式与上述指标的关系。结果 SGA生后3 d和4周岁时空腹胰岛素及HOMA-IR值均显著高于AGA(P<0.05);SGA中无体重追赶生长儿胰岛素及HOMA-IR值均显著高于有体重追赶生长儿(P<0.01);但HOMA-β值在各组中差异无统计学意义(P>0.05)。结论 SGA在生后至学龄前期出现胰岛素抵抗;且无体重追赶生长儿胰岛素抵抗水平更高;但胰岛β细胞分泌功能无明显改变。

关键词: 小于胎龄儿, 胰岛素抵抗, 生长方式

Abstract: Objective To explore the relationship between growth pattern from birth to preschool age and insulin resistance. Methods Fasting glucose, insulin, HOMA-IR and HOMA-β value in 68 small for gestaional age(SGA) infants and 42 appropriate for gestaional age(AGA) infants at age 3-day and 4-year were studied by a prospective study, and the relations with growth pattern were analyzed in 68 SGA infants. Results SGA infants had significantly higher fasting insulin concentration and HOMA-IR value than AGA infants at age 3-day and 4-year (P<0.05).No catch-up growth of weight in SGA infants had significantly higher fasting insulin concentration and HOMA-IR value than catch-up growth of weight in SGA infants(P<0.01).There was no significant difference in HOMA-β value among each groups (P>0.05). Conclusions SGA infants display insulin resistance from birth to preschool age.No catch-up growth of weight in SGA infants have higher insulin resistance.The function of β-cell of pancreatic islands has no remarkable change.

Key words: small for gestaional age infant, insulin resistance, growth pattern

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