关键词: 肺表面活性物质, 新生儿呼吸窘迫综合征, 早产儿

Abstract: Objective To investigate the preventive effect of pulmonary surfactant (PS) on neonatal respiratory distress syndrome (NRDS) in preterm infants. Methods Intervention study was used.A total of 91 premature infants were selected as prevented group to receive PS,and 90 premature infants were selected as control group.All infants came from two hospitals in Guangzhou.General situation,oxygen partial pressure (PO₂),carbon dioxide partial pressure (PCO₂) and oxygen saturation (SPO₂) index during different periods before and after treatment,NRDS outcome between the two groups were investigated. Results The demographic variables between the two groups were comparable.Before receiving PS,the PO₂,PCO₂ and SPO₂ between the two groups were not significantly different.The values of PO₂ and PCO₂ after 1,6,12,24 hours of treatment in prevented group were significantly higher than those in control group.The NRDS incidence rate of prevented group (20%) was significantly lower than control group (60%).The using time of respirator and medical costs of prevented group were lower than those of control group.For the prevented group,SPO₂ values after 1,6,12,24 hours of PS using were significantly higher than that before treatment,and PCO₂ values were significantly lower than that before treatment.The preventive effect was better for infants with 30~34 gestational weeks than those less than 30 gestational weeks. Conclusions The preventive use of PS can effectively improve the pulmonary ventilation and oxygenation capacity,reduce the incidence of NRDS.And it can also reduce mechanical ventilation using time.The effect is better for premature infants with 30~34 gestational weeks.

Key words: pulmonary surfactant, neonatal respiratory distress syndrome, preterm infants