妊娠晚期邻苯基苯酚暴露与新生儿体格指标的关系

doi:10.11852/zgetbjzz2016-24-02-08

中国儿童保健杂志 ›› 2016, Vol. 24 ›› Issue (2): 137-140.DOI: 10.11852/zgetbjzz2016-24-02-08

妊娠晚期邻苯基苯酚暴露与新生儿体格指标的关系

梁卫玖¹,吕沈亮²,郭剑秋²,卢大胜³,邬春华²,许浩¹,周志俊²

1 上海市长宁区疾病预防控制中心,上海 200051;
2 复旦大学公共卫生学院,上海 200032;
3 上海市疾病预防控制中心,上海 200336

收稿日期:2015-06-27 发布日期:2016-02-01 出版日期:2016-02-01
通讯作者: 许浩,E-mail:cnwj6274@163.com
作者简介:梁卫玖(1969-),男,上海人,主管技师,主要研究方向为环境污染物分析及对儿童健康的影响。

Association between exposure to o-phenylphenol during pregnancy and offspring size at birth

LIANG Wei-jiu¹,LV Shen-liang²,GUO Jian-qiu²,LU Da-sheng³,WU Chun-hua²,XU Hao¹,ZHOU Zhi-jun²

1 Shanghai Changning District Center for Disease Control &Prevention,Shanghai 200051,China;
2 School of Public Health,Fudan University,Shanghai 200032,China;
3 Shanghai Municipal Center for Disease Control & Prevention,Shanghai 200336,China

Received:2015-06-27 Online:2016-02-01 Published:2016-02-01
Contact: XU Hao,E-mail:cnwj6274@163.com

摘要/Abstract

摘要： 目的探讨孕妇妊娠晚期尿中邻苯基苯酚(o-phenylphenol,OPP)水平与新生儿出生体格指标之间联系。方法选取某县1 100对孕妇-新生儿,采集孕妇分娩前尿样并完成调查问卷,测定尿中OPP浓度,结合新生儿体格指标进行统计分析。结果孕妇尿中OPP的检出率为100%,中位值为0.35 μg/L,肌酐校正后中位值为0.54 μg/g,暴露水平稍高于国外类似研究报道。广义线性模型分析显示,孕妇尿中OPP肌酐校正浓度对数可能与新生儿出生身长(β=-0.670,P=0.006)及头围(β=-0.505,P=0.001)呈一定的负相关。按新生儿性别分层后,OPP水平可能与男童身长、体重及头围呈一定程度的负相关(P<0.05),而女童则未发现任何相关。结论该地区孕妇普遍暴露于OPP,其妊娠晚期OPP水平可能与男性新生儿出生身长、体重及头围呈一定负相关。

关键词: 邻苯基苯酚, 暴露评估, 新生儿, 出生体格指标

Abstract: Objective To assess the association between prenatal exposures to o-phenylphenol (OPP) and newborns' growth. Methods Questionnaires and spot urine samples were collected from 1 100 pregnant women living in a county of Jiangsu Province.Urinary concentrations of OPP were determined.Associations between maternal urinary concentration of OPP and neonate birth outcomes were investigated. Results Urinary OPP was detected in all samples,and the median values were 0.35 μg/L and 0.54 μg/g creatinine.Generalized linear model indicated that log-transformed OPP concentrations with creatinine correction were negatively associated with birth length (β=-0.670,P=0.006) and head circumference at birth (β=-0.505,P=0.001).OPP concentrations were negatively associated with length,weight and head circumference at birth among male newborns (P<0.05). Conclusion The findings suggest that the pregnant women are widely exposed to OPP in the studied county and urinary OPP concentrations of pregnant women are negatively associated with birth size among male newborns.

Key words: o-phenylphenol, exposure assessment, newborns, birth size

中图分类号:

R179

梁卫玖,吕沈亮,郭剑秋,卢大胜,邬春华,许浩,周志俊. 妊娠晚期邻苯基苯酚暴露与新生儿体格指标的关系[J]. 中国儿童保健杂志, 2016, 24(2): 137-140.

LIANG Wei-jiu,LV Shen-liang,GUO Jian-qiu,LU Da-sheng,WU Chun-hua,XU Hao,ZHOU Zhi-jun. Association between exposure to o-phenylphenol during pregnancy and offspring size at birth[J]. journal1, 2016, 24(2): 137-140.

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妊娠晚期邻苯基苯酚暴露与新生儿体格指标的关系

Association between exposure to o-phenylphenol during pregnancy and offspring size at birth

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