关键词: 法洛四联症, 先天性心脏病, 胃饥饿素, 超敏C反应蛋白

Abstract: Objective To investigate the roles of both serum ghrelin and high-sensibivity CRP (hs-CRP) on myocardial hypoxia inflammation in children with tetralogy of Fallot(TOF). Method Serum which were collected from children with TOF (TOF group,n=60) from our Diagnosis and Treatment Center of Congenital Heart Disease from January,2011 to May,2015 and healthy children(control group,n=30) in the same period were examined for ghrelin and hs-CRP.Serum concentrations of both ghrelin and hs-CRP of two groups were compared while their correlation were analyzed. Result The levels of both ghrelin and hs-CRP in children with TOF groups were significantly higher than these in controls (P<0.01),and ghrelin had positive correlation with hs-CRP. Conclusion Serum ghrelin in children with TOF is positively correlated with serum hs-CRP,which suggests that serum ghrelin plays certain protection role on myocardial hypoxia inflammation in children with TOF.

Key words: tetralogy of Fallot, congenital heart disease, ghrelin, high-sensitivity CRP