关键词: 边缘型维生素A缺乏, 反复呼吸道感染, 急性感染, 儿童

Abstract: Objective To explore the relationship between marginal vitamin A deficiency and respiratory tract infections in children and its risk factors. Methods One hundred and sixty children between April 2015 and October 2015 were enrolled in the study,including 42 cases of RRI in acute infection (A group),24 cases of repeated respiratory infection (RRI) in non-acute infection (B group),18 cases of acute respiratory tract infection (C group) and 76 health children (D group).The serum vitamin A level was measured by high performance liquid chromatography (HPLC).Serum VA level ranged from 0.20 to 0.30 mg/L was considered as marginal vitamin A deficiency (MVAD). Results 1)The serum VA levels of A group[(0.27±0.07) mg/L],B group[(0.28±0.04) mg/L] and C group[(0.28±0.09) mg/L] were lower than those of D group[(0.33±0.08) mg/L] (P<0.05).2)The incidence of MVAD in RRI children was significantly higher than that in non-RRI children (P<0.05).3)Logistic regression analysis showed that living in rural area,poor appetite and having acute respiratory infection all were risk factors for MVAD. Conclusions Vitamin A deficiency may be one of the important reasons of RRI in children,and acute infection can aggravate the lack of VA in vivo.Children who were living in rural area,with poor appetite or having acute respiratory infection,were more susceptible for MVAD.

Key words: marginal vitamin A deficiency, repeated respiratory infection, acute infection, child