中国儿童保健杂志 ›› 2016, Vol. 24 ›› Issue (8): 887-888.DOI: 10.11852/zgetbjzz2016-24-08-31

• 经验交流 • 上一篇    下一篇

支气管哮喘儿童血清sFas、sFasL的临床意义

冯金环1,王孟兰1,张俊英1,王晓健2   

  1. 青大医学院附属青岛海慈医院,1 儿科;
    2 血液透析室,山东 青岛 266033
  • 收稿日期:2016-02-19 发布日期:2016-08-10 出版日期:2016-08-10
  • 通讯作者: 王孟兰,E-mail:wangmenglanwml@126.com
  • 作者简介:冯金环(1965-),女,山东人,主任医师/教授,硕士学位,主要研究方向为为儿童免疫及哮喘。

Clinic significance of sFas/sFasL in serum of children with asthma.

FENG Jin-huan1,WANG Meng-lan1,ZHANG Jun-ying1,WANG Xiao-jian2.   

  1. 1 Department of Pediatrics;
    2 Department of Blood Purify,Hiser Hospital Affiliated to Medical College of Qingdao University,Qingdao,Shandong 266033,China
  • Received:2016-02-19 Online:2016-08-10 Published:2016-08-10
  • Contact: WANG Meng-lan,E-mail:wangmenglanwml@126.com

摘要: 目的 研究支气管哮喘儿童血清可溶性Fas受体和Fas配体(sFas/sFasL)的水平变化及临床意义。方法 选取67例支气管哮喘儿童(哮喘组)及健康儿童40例(对照组),采用双抗体夹心(ABC-ELISA)法检测哮喘组及对照组血清sFas、sFasL水平,并进行比较。结果 哮喘组血清sFas、sFasL水平分别为(91.89±21.25)、(1 080.37±306.59) ng/L均明显高于对照组的(29.58±7.26 )、(496.70±47.60) ng/L,差异有统计学意义(P<0.01)。结论 sFas、sFasL可能参与了儿童支气管哮喘的发病过程。

关键词: 儿童, 哮喘, sFas, sFasL, 凋亡

Abstract: Objective To explore the clinic significance of sFas/sFasL in serum of children with asthma. Methods A total of 67 children with asthma (asthma group) and 40 healthy children (healthy control group) were selected,sFas,sFasL in their serums were detected by ABC-ELISA. Results Compared with healthy control group,the sFas and sFasL in serum of asthma group were elevated markedly(P<0.01). Conclusion The sFas,sFasL in children with asthma were higher than healthy children,sFas/ sFasL maybe take part in the pathological process of asthma.

Key words: asthma, children, SFas, FasL, apoptosis

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