陕西省冬春季婴幼儿肠道菌群定植抗力的影响因素研究

doi:10.11852/zgetbjzz2017-25-10-04

中国儿童保健杂志 ›› 2017, Vol. 25 ›› Issue (10): 984-988.DOI: 10.11852/zgetbjzz2017-25-10-04

陕西省冬春季婴幼儿肠道菌群定植抗力的影响因素研究

何国斌¹,虞荣斌^1*,朱中海¹,李文浩¹,孙超¹,李文静¹,韩蓓²,程悦^1,2,颜虹^1,2,曾令霞¹

1 西安交通大学医学部公共卫生学院流行病与卫生统计学系,陕西西安 710061;
2 陕西省营养与食品安全工程研究中心,陕西西安 710061

收稿日期:2017-05-09 发布日期:2017-10-10 出版日期:2017-10-10
作者简介:何国斌(1993-),男,浙江人,在读研究生,研究方向为妇幼保健及人群健康评价。虞荣斌(1990-),男,浙江人,研究生,研究方向为妇幼保健及人群健康评价。
基金资助:
国家自然科学基金(81373019)

Study on influencing factors of intestinal microbial colonization resistance among infants and young children in winter and spring season in Shaanxi province

HE Guo-bin¹,YU Rong-bin¹,ZHU Zhong-hai¹,LI Wen-hao¹,SUN Chao¹,LI Wen-jing¹,HAN Bei²,CHENG Yue^1,2,YAN Hong^1,2,ZENG Ling-xia¹

1 Department of Epidemiology and Health Statistics,School of Public Health,Health Science Center,Xi'an Jiaotong University,Xi'an,Shaanxi 710061,China;
2 Nutrition and Food Safety Engineering Research Center of Shaanxi Province,Xi'an,Shaanxi 710061,China

Received:2017-05-09 Online:2017-10-10 Published:2017-10-10
Contact: ZENG Ling-xia,E-mail:tjzlx@mail.xjtu.edu.cn

摘要/Abstract

摘要： 目的研究陕西省婴幼儿冬春季肠道菌群定植抗力的影响因素,为改善婴幼儿肠道菌群定植抗力提供科学依据。方法采用1∶1病例对照研究设计,按照年龄分层,抽取数量相当的腹泻患儿和健康婴幼儿,采集粪便样本同时收集婴幼儿的社会人口学信息、喂养及腹泻患病相关信息。采用二代测序的技术检测样本粪便中微生物群落的组成结构和多样性。结果城市户口(Z=4.57,P＜0.001),顺产(Z=2.75,P=0.01),母亲文化程度更高(Z=1.72,P=0.04)及母亲工作类型属于脑力劳动型(Z=2.74,P=0.01)婴幼儿的粪便微生物定植抗力更强。腹泻组婴幼儿的B/E值为0.13±0.27,肠道菌群定植抗力要强于正常对照组婴幼儿(F=5.419,P=0.022);肠道菌群的定植抗力随着月龄的增加而显著增强(F=2.357,P=0.076);辅食模式为“添加肉类辅食不添加维生素和矿物质”组的B/E值为0.374±0.532,定植抗力较强(F=5.976,P=0.001)。胃肠道微生物菌群的多样性与消化道定植抗力的增加呈正相关。结论提高母亲文化程度,提倡正常顺产,普及科学合理的婴幼儿喂养模式可以改善婴幼儿肠道菌群定植抗力。

关键词: 肠道菌群, 定植抗力, 婴幼儿

Abstract: Objective To explore the influencing factors of intestinal microbial colonization resistance among infants and young children in Shaanxi province,and to provide scientific basis for enhancing the colonization resistance. Methods A case control study by 1∶1 design was employed in this research,with equivalent number of diarrhea and healthy children stratified by month of age.Structured questionnaires were used to collect the sociodemographic characteristics,feeding patterns and information associated with the prevalence of diarrhea,stool samples of young children were collected as well.The structure and diversity of microbial communities in feces were detected by Illumina sequencing. Results Sociodemographic characteristics such as residential type (Z=4.57,P＜0.001),delivery mode (Z=2.75,P=0.01),mother's level of education (Z=1.72,P=0.04),diarrhea (F=2.357,P=0.076) and supplementary pattern (F=5.976,P=0.001),were significantly associated with intestinal microbial colonization resistance of infants.Diversity of intestinal microbiota was positively correlated with colonization resistance. Conclusions Improving mother's education,advocating natural birth,and popularizing scientific and rational feeding pattern could enhance the intestinal microbial colonization resistance in infants and young children.

Key words: intestinal microbiota, colonization resistance, young children

中图分类号:

R179

何国斌,虞荣斌,朱中海,李文浩,孙超,李文静,韩蓓,程悦,颜虹,曾令霞. 陕西省冬春季婴幼儿肠道菌群定植抗力的影响因素研究[J]. 中国儿童保健杂志, 2017, 25(10): 984-988.

HE Guo-bin,YU Rong-bin,ZHU Zhong-hai,LI Wen-hao,SUN Chao,LI Wen-jing,HAN Bei,CHENG Yue,YAN Hong,ZENG Ling-xia. Study on influencing factors of intestinal microbial colonization resistance among infants and young children in winter and spring season in Shaanxi province[J]. journal1, 2017, 25(10): 984-988.

0
/ / 推荐

导出引用管理器 EndNote|Ris|BibTeX

链接本文: https://manu41.magtech.com.cn/Jwk_zgetbjzz/CN/10.11852/zgetbjzz2017-25-10-04

https://manu41.magtech.com.cn/Jwk_zgetbjzz/CN/Y2017/V25/I10/984

参考文献

[1] Vanderwaaij D,Berghuis JM,Lekkerke JE.Colonization resistance of the digestive tract in conventional and antibiotic-treated mice[J].J Hyg,1971,69(3):405-411.
[2] Lim ES,Wang D,Holtz LR.The bacterial microbiome and virome milestones of infant development[J].Trends Microbiol,2016,24(10):801-810.
[3] Buffington SA,Di Prisco GV,Auchtung TA,et al.Microbial reconstitution reverses maternal diet-induced social and synaptic deficits in offspring[J].CELL,2016,165(7):1762-1775.
[4] Tamburini S,Shen N,Wu HC,et al.The microbiome in early life:implications for health outcomes[J].Nat Med,2016,22(7):713-722.
[5] 吴仲文,李兰娟,马伟杭,等.肠道微生物定植抗力的新指标-B/E值[J].浙江预防医学,2000,12(7):4-5.
[6] 刘铜林,罗小平.儿科疾病诊疗指南[M].北京:科学出版社,2014:134-135.
[7] Chang JY,Antonopoulos DA,Kalra A,et al.Decreased diversity of the fecal microbiome in recurrent Clostridium difficile-associated diarrhea[J].J Infect Dis,2008,197(3):435-438.
[8] Khoruts A,Dicksved J,Jansson JK,et al.Changes in the composition of the human fecal microbiome after bacteriotherapy for recurrent Clostridium difficile-associated diarrhea[J].J Clin Gastroenterol,2010,44(5):354-360.
[9] Preidis GA,Versalovic J.Targeting the human microbiome with antibiotics,probiotics,and prebiotics:gastroenterology enters the metagenomics era[J].Gastroenterology,2009,136(6):2015-2031.
[10] Dominguez-Bello MG,Costello EK,Contreras M,et al.Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns[J].Proc Natl Acad Sci USA,2010,107(26):11971-11975.
[11] 张水平,刘黎明,孙晓勉,等.陕西农村母乳喂养儿肠道菌群定植抗力的研究[J].中国妇幼健康研究,2008,19(3):193-195.
[12] Hascoet JM,Hubert C,Rochat F,et al.Effect of formula composition on the development of infant gut microbiota[J].J Pediatr Gastroenterol Nutr,2011,52(6):756-762.
[13] Azad MB,Konya T,Maughan H,et al.Gut microbiota of healthy Canadian infants:profiles by mode of delivery and infant diet at 4 months[J].CMAJ,2013,185(5):385-394.
[14] Schaubeck M,Clavel T,Calasan J,et al.Dysbiotic gut microbiota causes transmissible Crohn's disease-like ileitis independent of failure in antimicrobial defence[J].GUT,2016,65(2):225-237.
[15] Goulet O.Potential role of the intestinal microbiota in programming health and disease[J].Nutr Rev,2015,731:32-40.

陕西省冬春季婴幼儿肠道菌群定植抗力的影响因素研究

Study on influencing factors of intestinal microbial colonization resistance among infants and young children in winter and spring season in Shaanxi province

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	孔文瑞, 许梦雪, 贾妮, 穆立娟, 韩颖, 李秋菊, 孟召学, 王淑兰, 朱宗涵, 关宏岩. 北京市0～3岁婴幼儿家长养育照护能力现状及影响因素分析[J]. 中国儿童保健杂志, 2023, 31(7): 741-745.
[2]	张丹, 张军, 杨钰荣, 曹咪, 闫敬敏, 朱璐阳. 肠道菌群与早产儿脑发育及神经认知行为关系的研究[J]. 中国儿童保健杂志, 2023, 31(7): 756-759.
[3]	王丹, 黄垂灿, 樊利春. 回应性喂养对婴幼儿睡眠影响的研究进展[J]. 中国儿童保健杂志, 2023, 31(6): 656-660.
[4]	李德欣, 陈强, 庄志成, 陈红, 杨秉娇, 姜顺香, 周翔. 孤独症谱系障碍儿童肠道菌群与症状严重程度相关性研究[J]. 中国儿童保健杂志, 2023, 31(5): 497-501.
[5]	毛萌. 婴幼儿生长迟缓的早期识别与早期干预[J]. 中国儿童保健杂志, 2023, 31(4): 349-352.
[6]	李正, 肖贵元, 罗雅婷, 何春燕, 王念蓉, 赵妍. 孤独症谱系障碍儿童血清叶酸、维生素B12水平与肠道菌群的关联[J]. 中国儿童保健杂志, 2023, 31(3): 246-251.
[7]	张雨平. 婴幼儿脑损伤及其早期评估[J]. 中国儿童保健杂志, 2023, 31(2): 123-125.
[8]	黄亨烨, 于广军. 婴幼儿早期神经发育评估诊断量表的综述[J]. 中国儿童保健杂志, 2023, 31(2): 162-166.
[9]	张蕾, 胡耀芳, 葛俞伽, 董菁, 刘潘婷, 池霞, 童梅玲, 钱君. 头颅畸形婴幼儿头颅形态特征及影响因素分析[J]. 中国儿童保健杂志, 2023, 31(2): 200-204.
[10]	尹春岚, 奚翔云, 童梅玲, 朱玲, 张华, 刘云芬, 黄燕, 张永花, 章丽丽, 崔欣华, 倪育, 钟新文, 李霞, 许培斌. 婴幼儿家庭养育照护指导需求分析[J]. 中国儿童保健杂志, 2023, 31(1): 32-36.
[11]	王晓彤, 常佳慧, 刘爱华, 张健, 吴琼, 张延峰, 张霆, 朱宗涵. 婴儿期俯卧活动的研究进展[J]. 中国儿童保健杂志, 2023, 31(1): 58-61.
[12]	徐玉英, 王雪娜, 李佳, 安子芬, 余立平. 婴幼儿回应性照护的研究进展[J]. 中国儿童保健杂志, 2023, 31(1): 71-75.
[13]	王硕, 李心悦, 魏瑗, 刘鹭燕, 李在玲, 张华. 母亲孕晚期肠道菌群与婴儿食物过敏的关系[J]. 中国儿童保健杂志, 2022, 30(9): 941-946.
[14]	刘岩, 李智慧, 孔燕, 尹春岚, 于桂玲. 婴幼儿食欲特征及气质在积极喂养行为和体质指数间的中介调节作用[J]. 中国儿童保健杂志, 2022, 30(9): 965-969.
[15]	贾妮, 许梦雪, 丁美琦, 严双琴, 章青兰, 王宝珍, 李园园, 关宏岩. 中文版亲子互动-喂养量表的信效度初步研究[J]. 中国儿童保健杂志, 2022, 30(8): 839-844.