基于磁共振成像的注意缺陷多动障碍认知神经机制研究进展

doi:10.11852/zgetbjzz2018-26-04-13

中国儿童保健杂志 ›› 2018, Vol. 26 ›› Issue (4): 396-398.DOI: 10.11852/zgetbjzz2018-26-04-13

基于磁共振成像的注意缺陷多动障碍认知神经机制研究进展

赵俊秀¹, 徐雯¹, 孙锦华^1,2

1 上海交通大学医学院附属精神卫生中心儿少精神科,上海 200030;
2 上海交通大学附属第一人民医院医学心理科,上海 200080;

收稿日期:2017-07-22 发布日期:2018-04-10 出版日期:2018-04-10
通讯作者: 孙锦华,E-mail:2005sunjinhua@163.com
作者简介:赵俊秀(1993-),女,硕士研究生在读,主要研究方向为儿童多动症的认知神经机制。
基金资助:
上海市自然科学基金(14ZR1435800,10ZR1425600);上海市卫生局青年基金项目(2009Y049);国家自然科学基金面上项目(81251511);上海市磁共振重点实验室(华东师范大学)开放课题基金(2010)

Research progress on cognitive neural mechanisms of attention deficit/hyperactivity disorder based on the studies of magnetic resonance imaging

ZHAO Jun-xiu¹, XU Wen¹, SUN Jin-hua^1,2

1 Department of Child & Adolescent Psychiatry,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China;
2 Department of Medical Psychology,Shanghai General Hospital,Shanghai 200080,China

Received:2017-07-22 Online:2018-04-10 Published:2018-04-10
Contact: SUN Jin-hua,E-mail:2005sunjinhua@163.com

摘要/Abstract

摘要： 注意缺陷多动障碍(ADHD)是一种儿童期常见的神经发育性障碍,发病率高,以注意力难以持续集中、多动和冲动为明显特征。该症给患者的学习生活、人际关系以及家庭带来诸多困扰与痛苦,因此探索ADHD的发病机制对于探索新的治疗手段、提高临床预后、减轻患儿的疾病造成的痛苦具有重要意义。近年来神经影像学研究发展迅速,借助于脑影像学技术与方法,探究ADHD的神经机制已获取不少有意义的发现。本文拟对ADHD磁共振功能成像以及弥散张量成像研究文献进行综述,以加深对ADHD神经机制的认识与理解,服务于临床。

关键词: 注意缺陷多动障碍, 神经机制, 磁共振功能成像, 弥散张量成像

Abstract: Attention deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder with high incidence rate,characterized by unsustainable attention and/or hyperactive/impulsive behavior causing much trouble and pain to the study,life,interpersonal relationship and family of the patients.Therefore,studying the pathogenesis of ADHD is of great significance for exploring new therapies,improving clinical prognosis and alleviating patient's pain caused by the disease.Neuroimaging studies have developed rapidly in recent years,and with the aid of techniques and approaches of brain imaging,exploring the neural mechanism of ADHD has been explored thereby showing varieties of interesting results.This paper reviews the ADHD literatures on the functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI),in order to deepen the knowledge and understanding of the neural mechanisms of ADHD,and to provide evidence for clinical practice.

Key words: attention deficit/hyperactivity disorder, neural mechanism, functional magnetic resonance imaging, diffusion tensor imaging

中图分类号:

R179

赵俊秀, 徐雯, 孙锦华. 基于磁共振成像的注意缺陷多动障碍认知神经机制研究进展[J]. 中国儿童保健杂志, 2018, 26(4): 396-398.

ZHAO Jun-xiu, XU Wen, SUN Jin-hua. Research progress on cognitive neural mechanisms of attention deficit/hyperactivity disorder based on the studies of magnetic resonance imaging[J]. journal1, 2018, 26(4): 396-398.

参考文献

[1] Biederman J,Faraone SV.The effects of attention-deficit/hyperactivity disorder on employment and household income[J].Med Gen Med,2006,8(3):10-12.
[2] 饶延华,古天明,章顺悦,等.儿童青少年注意力缺陷障碍合并品行障碍的流行病学研究[J].中国社会医学杂志,2010,27(6):360-362.
[3] 童连,史慧静,臧嘉捷.中国儿童ADHD流行状况Meta分析[J].中国公共卫生,2013,29(9):1279-1283.
[4] Emond V,Joyal C,Poissant H.Structural and functional neuroanatomy of attention-deficit hyperactivity disorder(ADHD)[J].Encephale,2009,35(2):107-114.
[5] Cubillo A,Halari R,Ecker C,et al.Reduced activation and inter-regional functional connectivity of fronto-striatal networks in adults with childhood attention-deficit hyperactivity disorder(ADHD) and persisting symptoms during tasks of motor inhibition and cognitive switching[J].J Psychiatr Res,2010,44(10):629-639.
[6] Cubillo A,Halari R,Smith A,et al.A review of fronto-striatal and fronto-cortical brain abnormalities in children and adults with Attention Deficit Hyperactivity Disorder (ADHD) and new evidence for dysfunction in adults with ADHD during motivation and attention[J].Cortex,2012,48(2):194-215.
[7] Christakou A,Murphy CM,Chantiluke K,et al.Disorder-specific functional abnormalities during sustained attention in youth with attention deficit hyperactivity disorder and with autism[J].Mol Psychiatry,2013,18(2):236-244.
[8] Hart H,Radua J,Nakao T,et al.Meta-analysis of functional magnetic resonance imaging studies of inhibition and attention in attention-deficit/hyperactivity disorder:exploring task-specific,stimulant medication,and age effects[J].JAMA Psychiatry,2013,70(2):185-198.
[9] Lui JHL,Johnston C,Lee CM,et al.Parental ADHD symptoms and self-reports of positive parenting[J].J Consul Clin Psychol,2013,81(6):988-998.
[10] Depue BE,Burgess GC,Willcutt EG,et al.Inhibitory control of memory retrieval and motor processing associated with the right lateral prefrontal cortex:evidence from deficits in individuals with ADHD[J].Neuropsychologia,2010,48(13):3909-3917. [11] Dickstein SG,Bannon K,Castellanos FX,et al.The neural correlates of attention deficit hyperactivity disorder:An ALE meta-analysis[J].J Child Psychol Psychiatry,2006,47(10):1051-1062.
[12] Durston S,Tottenham NT,Thomas KM,et al.Differential patterns of striatal activation in young children with and without ADHD[J].Biol Psychiatry,2003,53(10):871-878.
[13] Valera EM,Faraone SV,Biederman J,et al.Functional neuroanatomy of working memory in adults with attention-deficit/hyperactivity disorder[J].Biol Psychiatry,2005,57(5):439-447.
[14] Konrad K,Eickhoff SB.Is the ADHD brain wired differently? A review on structural and functional connectivity in attention deficit hyperactivity disorder[J].Hum Brain Mapp,2010,31(6):904-916.
[15] 任姣姣,岳婕.儿童注意缺陷多动障碍发病机制的研究进展[J].中国妇幼健康研究,2016,27(7):894-896.
[16] Kobel M,Bechtel N,Specht K,et al.Structural and functional imaging approaches in attention deficit/hyperactivity disorder:does the temporal lobe play a key role[J].Psychiatry Res,2010,183(7):230-236.
[17] Ashtari M,Kumra S,Bhaskar SL,et al.Attention-deficit/hyperactivity disorder:a preliminary diffusion tensor imaging study[J].Biol Psychiatry,2005,57(5):448-455.
[18] Van Ewi JK,Heslenfeld DJ,Zwiers MP,et al.Diffusion tensor imaging in attention deficit/hyperactivity disorder:a systematic review and meta-analysis[J].Neuroscience and Biobehavioral Reviews,2012,36(4):1093-1106.
[19] Jacobson LA,Peterson DJ,Rosch KS,et al.Sex-based dissociation of white matter microstructure in children with attention-deficit/hyperactivity disorder[J].J Am Acad Child Adolesc Psychiatry,2015,54(11):938-946.
[20] Ercan ES,Suren S,Bacanli A,et al.Altered structural connectivity is related to attention deficit/hyperactivity subtypes:A DTI study[J].Psychiatry Res,2016,256:57-64.
[21] Bos DJ,Oranje B,Achterberg M,et al.Structural and functional connectivity in children and adolescents with and without attention deficit/hyperactivity disorder[J].J Child Psychol Psychiatry,2017,58(7):810-818.
[22] Vance A,Silk TJ,Casey M,et al.Right parietal dysfunction in children with attention deficit hyperactivity disorder,combined type:a functional MRI study[J].Mol Psychiatry,2007,12(9):826-832.
[23] Davenport ND,Karatekin C,White T,et al.Differential fractional anisotropy abnormalities in adolescents with ADHD or schizophrenia[J].Psychiatry Res,2010,181(3):193-198.

基于磁共振成像的注意缺陷多动障碍认知神经机制研究进展

Research progress on cognitive neural mechanisms of attention deficit/hyperactivity disorder based on the studies of magnetic resonance imaging

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	李荣, 李年, 吴丹丹, 黄荣, 陈银花. 盐酸哌甲酯缓释片对注意缺陷多动障碍儿童生长的影响[J]. 中国儿童保健杂志, 2023, 31(7): 731-735.
[2]	张婕, 安英萍, 杨毅, 张艳楠, 田琳. 从全生命周期视角识别和治疗注意缺陷多动障碍女童和女性的专家共识(2020年版)解读[J]. 中国儿童保健杂志, 2023, 31(5): 570-575.
[3]	易文霞, 陈立. 注意缺陷多动障碍儿童父母养育压力研究进展[J]. 中国儿童保健杂志, 2023, 31(4): 408-411.
[4]	刘芮卓, 陈立. 儿童注意缺陷多动障碍与肥胖的相关性研究[J]. 中国儿童保健杂志, 2023, 31(4): 412-415.
[5]	朱笑彤, 任园春, 刘靖, 李雪, 王芳, 尹婷妮, 谢永涛, 宋懿芪, 范碧瑶, 吉宁. 注意缺陷多动障碍小学生精细动作发展特点研究[J]. 中国儿童保健杂志, 2023, 31(3): 322-326.
[6]	周梅君, 魏蓉美, 袁晓玲, 赵婷, 赵硕. 小组训练对学龄前注意缺陷多动障碍儿童注意品质的干预效果[J]. 中国儿童保健杂志, 2023, 31(3): 336-340.
[7]	黄琦, 黄欣欣, 钱沁芳, 王章琼, 李国凯. 注意缺陷多动障碍共患发育性协调障碍的学龄前儿童智力结构特征[J]. 中国儿童保健杂志, 2023, 31(2): 136-140.
[8]	柴润玉, 王康程, 林华伟, 张俊英, 邢婕, 张华, 曹爱华. 注意缺陷多动障碍儿童及其父母攻击行为相互作用的网络分析[J]. 中国儿童保健杂志, 2022, 30(8): 845-850.
[9]	邓岚柳, 陈立. 药物治疗对注意缺陷多动障碍患儿体格生长影响的研究进展[J]. 中国儿童保健杂志, 2022, 30(8): 874-878.
[10]	房海波, 王荣, 褚琳娜, 冯艳芳, 白容荣, 郭丰桐. 血清维生素D水平与伴中央颞区棘波的儿童良性癫痫共患注意缺陷多动障碍患儿认知功能的相关性分析[J]. 中国儿童保健杂志, 2022, 30(7): 775-778.
[11]	陈书进, 吴丹丹, 李晓南. 注意缺陷多动障碍和肥胖共病机制的研究进展[J]. 中国儿童保健杂志, 2022, 30(4): 401-404.
[12]	方圆, 孔维延, 马晨欢, 潘丽珠, 朱佩滢, 王瑜. 注意缺陷多动障碍儿童过敏性疾病发生情况的调查[J]. 中国儿童保健杂志, 2022, 30(4): 431-435.
[13]	陈文材, 佐飞燕, 万莹, 王玫玲. 脑源性神经营养因子基因Val66Met多态性与注意缺陷多动障碍易感性的Meta分析[J]. 中国儿童保健杂志, 2022, 30(3): 301-305.
[14]	刘蕊, 王燕, 姜艳蕊, 白桦, 张瑞芳. 儿童注意缺陷多动障碍DSM-Ⅳ和DSM-5诊断的比较研究[J]. 中国儿童保健杂志, 2022, 30(3): 306-309.
[15]	董爽, 季忆婷, 王丹, 毛广惠, 颜崇淮, 蔡世忠, 陈艳. 学龄期注意缺陷/多动障碍儿童血铅水平及其与社会功能情况分析[J]. 中国儿童保健杂志, 2022, 30(2): 207-211.