关键词: 低敏配方, 牛奶过敏, 生长, 体成分, 婴儿

Abstract: Objective To longitudinally observe the physical growth, especially body composition (BC) in hypoallergenic formula (HF)-fed children with cow's milk allergy (CMA) in the early birth period. Methods Totally 60 HF-fed children under 4 months old were enrolled in this study from January 2014 to September 2015.Routine physical examinations were conducted till 1 year old. BC was measured using a PEA POD^® Infant Body Composition System during the first 6 months of life and assessed by skinfold anthropometry at 12 months old. Results The average age of infants at enrollment was (2.9±1.0) months old. Compared with healthy control of the same age, HF-fed CMA infants had significantly lower weight-for-age Z scores from 6 to 12 months and weight-for-length Z scores from 9 to 12 months; Also, the percent fat mass of HF-fed CMA infants was significantly lower than that of the control infants at the age of 6 months old (26.2% vs 30.3%,P=0.015) and 12 months old (23.8% vs 27.1%,P=0.028); The mean fat mass index (FMI) was at least 0.2 units lower than that of the control infants, but the difference was not statistically significant(P＞0.05). Conclusion Infants with CMA, who are HF-fed in early period after birth, is likely to have weight gain and impaired and body fat accumulation.

Key words: hypoallergenic formula, cow's milk allergy, growth, body composition, infants