髓鞘碱性蛋白、神经元特异性烯醇化酶在支原体肺炎并发脑炎患儿中的临床研究

doi:10.11852/zgetbjzz2018-0204

中国儿童保健杂志 ›› 2019, Vol. 27 ›› Issue (2): 202-204.DOI: 10.11852/zgetbjzz2018-0204

髓鞘碱性蛋白、神经元特异性烯醇化酶在支原体肺炎并发脑炎患儿中的临床研究

李芹,王亚坤,田利远,张曼,王艳艳,李清涛,常海霞

河北省儿童医院呼吸一科,河北石家庄 050031

发布日期:2019-02-20 出版日期:2019-02-20
通讯作者: 田利远,E-mail:liqin0386@163.com
作者简介:李芹(1982-),女,主治医师,硕士学位,主要研究方向为儿科呼吸疾病的基础与临床
基金资助:
2018年度河北省医学科学研究重点课题计划(20180625)

Clinical study of myelin basic protein and neuron-specific enolase in children with mycoplasmal pneumouniae pneumounia complicated with encephalitis

LI Qin, WANG Ya-kun, TIAN Li-yuan, ZHANG Man, WANG Yan-yan, LI Qing-tao, CHANG Hai-xia

Department of Respiratory, Children^′s Hospital of Hebei Province, Shijiazhuang, Hebei 050031, China

Online:2019-02-20 Published:2019-02-20
Contact: TIAN Li-yuan,E-mail:liqin0386@163.com

摘要/Abstract

摘要： 目的测定脑脊液中髓鞘碱性蛋白(MBP)及神经元特异性烯醇化酶(NSE)的含量,探讨其在支原体肺炎并发脑炎患儿中的临床价值。方法 2016年4月-2017年10月选取68例支原体肺炎合并脑炎的患儿为实验组(包括非惊厥组36例,惊厥组32例),30例支原体肺炎患儿为对照组;采用ELISA方法检测脑脊液MBP、NSE的含量。结果惊厥组、非惊厥组患儿脑脊液MBP、NSE水平均显著高于对照组(P<0.05),且惊厥组均明显高于非惊厥组(P<0.05)。结论脑脊液MBP、NSE含量可作为评估支原体肺炎并发脑炎患儿中枢神经系统损伤及损伤程度的指标,这有助于临床医生及早判断病情和合理诊治。

关键词: 肺炎支原体肺炎, 脑炎, 髓鞘碱性蛋白, 神经元特异性烯醇化酶

Abstract: Objective To test the levels of myelin basic protein (MBP) and neuron-specific enolase(NSE) in the cerebrospinal fluid (CSF) of children with mycoplasmal pneumonia complicated with encephalitis, in order to explore the clinical value of MBP and NSE in the assessment of mycoplasmal pneumonia complicated with encephalitis. Methods Totally 68 cases with mycoplasmal pneumonia complicated with encephalitis were selected as experimental group (including 36 cases of non-convulsion group,32 cases of convulsion group) and 30 cases of mycoplasmal pneumonia in control group from April 2016 to October 2017.The contents of MBP and NSE in the cerebrospinal fluid (CSF) were tested by enzyme linked immunosorbent assay (ELISA). Result The levels of MBP and NSE in the cerebrospinal fluid of the convulsive group and the non-convulsive group were significantly higher than those in control group (P<0.05), and were also higher in convulsive group than non-convulsive group (P<0.05). Conclusion The content of MBP and NSE in CSF can be used as an index to evaluate the central nervous system injury and injury degree of children with mycoplasmal pneumonia complicated with encephalitis, which is helpful for clinicians to predict the condition and make reasonable diagnosis and treatment as soon as possible.

Key words: mycoplasmal pneumouniae pneumounia, encephalitis, myelin basic protein, neuron-specific enolase

中图分类号:

R725.6

李芹,王亚坤,田利远,张曼,王艳艳,李清涛,常海霞. 髓鞘碱性蛋白、神经元特异性烯醇化酶在支原体肺炎并发脑炎患儿中的临床研究[J]. 中国儿童保健杂志, 2019, 27(2): 202-204.

LI Qin, WANG Ya-kun, TIAN Li-yuan, ZHANG Man, WANG Yan-yan, LI Qing-tao, CHANG Hai-xia. Clinical study of myelin basic protein and neuron-specific enolase in children with mycoplasmal pneumouniae pneumounia complicated with encephalitis[J]. journal1, 2019, 27(2): 202-204.

参考文献

[1] 申昆玲.支原体肺炎[M]//胡亚美,江载芳,申昆玲.诸福棠实用儿科学上册.8版.北京:人民卫生出版社,2015:1280-1282.
[2] 罗世祺.神经系统感染性疾病[M]//胡亚美,江载芳,申昆玲.诸福棠实用儿科学下册.8版.北京:人民卫生出版社,2015:1988-1989.
[3] 于渍慧,王伟.小儿肺炎支原体肺炎并发脑炎15例临床分析[J].临床儿科杂志, 2008,26(11):930-930.
[4] 刘爱琳,李利.肺炎支原体肺炎患儿中枢神经系统损害及其机制[J].实用儿科临床杂志,2010,25(6):444-445.
[5] Thom SR,Bhopale VM,Fiher D.Delayed neuropathology after carbon monoxide is immune mediated [J].Proc Nat Acad Sci USA,2004,101(37):13660-13665.
[6] Ide T,Kamijo Y.Myelin basic protein in cerebrospinal fluid:a predictive marker of delayed encephalopathy from carbon monoxide poisoning[J].Am J Emerg Med,2008,26(8):908-912.
[7] Pritzker LB, Joshi S, Gowan JJ.Deimination of myelin basic protein.1.effect of deimination of arginyl residues of myelin basic protein on its structure and susceptibility to digestion by cathepsin D[J]. Biochemistry,2000,39 (18):5374-5381.
[8] Beppu T,Nishimoto H,Ishigaki D,et al.Assessment of damage to cerebral white matter fiber in the subacute phase after carbon monoxide poisoning using fractional anisotropy in diffusion tensor imaging[J]. Neuroradiology,2010,52(8):735-743.
[9] Kamijo Y, Soma K, Ide K.Recurrent myelin basic protein elevation in cerebrospinal fluid as a predictive marker of delayed encephalopathy after carbon monoxide poisoning[J].Am J Emerg Med,2007,25(4):483-485.
[10] Li Q, Song JJ, Zhang HY,et al.Dexamethasone therapy for preventing delayedencephalopathy after carbon monoxide poisoning[J]. Biotech Histochem,2015,90(8):1-7.
[11] 周燕青,朱晓东.神经元特异性烯醇化酶在小儿中枢神经系统疾病中的应用[J].中国小儿急救医学,2014,21(11):739-741.
[12] 尉娜,王建平,王家勤.病毒性脑炎患儿脑脊液水通道蛋白4、基质金属蛋白酶-9 及神经元特异性烯醇化酶水平变化[J].中华实用儿科临床杂志,2016,31 (5):388-389.

[1]	陈玉霞, 刘华艳, 范倩倩. 足月儿高胆红素血症神经元特异性烯醇化酶、经皮小时胆红素、总胆红素/白蛋白水平变化及与远期神经发育的相关性[J]. 中国儿童保健杂志, 2023, 31(1): 86-90.
[2]	梁穗新, 提运幸, 黄骏荣, 李秀红, 周雯嘉. 延迟亚低温保护氧糖剥夺-复氧复糖新生幼鼠脑白质损伤的机制研究[J]. 中国儿童保健杂志, 2022, 30(10): 1083-1087.
[3]	李九英, 李平真, 邱亚明. IL-33/ST2在肺炎支原体肺炎患儿外周血中的表达研究[J]. 中国儿童保健杂志, 2021, 29(3): 332-334.
[4]	盛江吟, 阮桂英, 尹燕丹, 洪燕, 苏群燕, 南向珍. 儿童肺炎支原体肺炎并发气管炎性狭窄的危险因素及预后[J]. 中国儿童保健杂志, 2020, 28(12): 1385-1388.
[5]	陈曦, 王永芹, 赵月华. 不同血糖水平的足月儿NSE、aEEG及VEEG的应用价值研究[J]. 中国儿童保健杂志, 2020, 28(11): 1286-1289.
[6]	王艳蕊, 王桂芳. 振幅整合脑电图联合血清NSE、S100-β水平在早产儿脑损伤诊断中的应用[J]. 中国儿童保健杂志, 2020, 28(11): 1290-1293.
[7]	苏乐, 梅玲华, 贺巧峰. 肺炎支原体肺炎患儿血清维生素D水平与肺外脏器受累的相关性研究[J]. 中国儿童保健杂志, 2019, 27(7): 782-785.
[8]	海元平, 崔兰, 李虹艾, 李帮涛, 黄婷, 向伟. 手足口病患儿血清神经元特异性烯醇化酶及儿茶酚胺水平的临床意义[J]. 中国儿童保健杂志, 2018, 26(2): 196-198.
[9]	刘金, 闫虹, 陈小庚, 程菲. 儿童血清维生素A、D、E水平与肺炎支原体肺炎相关性的临床研究[J]. 中国儿童保健杂志, 2018, 26(1): 97-99.
[10]	王石,李智超. 血清S100B蛋白和神经元特异性烯醇化酶在缺氧缺血性脑病诊断与预后判断中的价值[J]. 中国儿童保健杂志, 2015, 23(1): 90-92.
[11]	王芳，王晓莉，范蒙蒙，刘培莉，刘长云，赵岩松. 脐血单个核细胞对脑白质损伤低龄大鼠少突胶质细胞及髓鞘碱性蛋白的影响[J]. 中国儿童保健杂志, 2014, 22(10): 1051-1054.
[12]	顾家富,黄卫华,杨晓峰. 儿童患者超剂量应用抗生素致抗生素脑病误诊为病毒性脑炎临床分析[J]. 中国儿童保健杂志, 2013, 21(8): 872-875.
[13]	黄国日,潘革,李惠玲,兰卫华. 重型及危重型手足口病患儿高危因素的回顾性临床分析[J]. 中国儿童保健杂志, 2013, 21(5): 524-527.
[14]	张永明,刘秀云. 儿童肺炎支原体肺炎并发肺不张36例临床分析[J]. 中国儿童保健杂志, 2012, 20(7): 661-663.

髓鞘碱性蛋白、神经元特异性烯醇化酶在支原体肺炎并发脑炎患儿中的临床研究

Clinical study of myelin basic protein and neuron-specific enolase in children with mycoplasmal pneumouniae pneumounia complicated with encephalitis

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 14

编辑推荐

Metrics