关键词: 支气管肺发育不良, 超早产, 危险因素

Abstract: Objective To explore the risk factors of bronchopulmonary dysplasia(BPD) in extremely preterm infants,in order to provide reference for the prevention and treatment of BPD. Methods Clinical data in 102 extremely preterm infants in neonatal intensive care unit(NICU) were collected and retrospectively analyzed,who were admitted in Maternal and Child Health Hospital of Anhui Province at 24 hours after birth from January 2012 to December 2017,with gestational age less than 28 weeks and survived 28 days after birth.According to the diagnosis standard of BPD,these infants were divided into BPD group(n=77) and non BPD group(n=25). Results Among 102 extremely preterm infants,77(75.5％) cases developed BPD.Univariate analysis Results showed that male,gestational age,birth weight,days in hospital,maternal chorioamnionitis,early-onset neonatal sepsis,retinopathy of prematurity,pulmonary hypertension,the time of invasive mechanical ventilation,the duration of oxygen therapy were associated with the BPD occurrence in extremely preterm infants.Multivariate Logistic regression analysis indicated that pulmonary hypertension(OR=25.595,95%CI:1.155-567.379) and the duration of oxygen therapy(OR=1.676,95%CI:1.250-1.893) were the independent factors of BPD occurrence in extremely preterm infants. Conclusions The prevalence of BPD which can be influenced by many factors is really high in extremely preterm infants.Lowering pulmonary artery pressure,shortening the duration of oxygen therapy and adopting a comprehensive and standardized treatment at an early stage may decrease the development of BPD.

Key words: bronchopulmonary dysplasia, extremely premature, risk factors