关键词: 出生头围, 影响因素, 现况研究

Abstract: Objective To explore the influencing factors of neonatal head circumference,in order to provide basis for sample selection in reference range,and for screening microcephaly in zika virus infection. Methods A total of 48 928 cases born in Guangdong Women and Children′s Hospital were selected in this study from January 2014 to December 2017,and the clinical data were collected retrospectively.The influencing factors of head circumference at birth were analyzed by independent sample t test/variance analysis and multivariate generalized linear regression analysis. Results The average head circumference of neonates was(33.4±1.7)cm.The head circumference of male newborns,children with larger gestational age,neonates whose ancestral homes were from northern China,delivered by cesarean section and older pregnant women,children exposed to hydramnios multiple pregnancy,multiparity,gestational diabetes mellitus was larger(P<0.05).And the head circumference of children exposed to intrauterine growth restriction,umbilical cord around neck,umbilical cord torsion,oligohydramnios and gestational hypertension,cholestasis,anemia was smaller(P<0.05).There were no significant differences on head circumference among neonates with abnormal structure,assisted reproductive,amniotic fluid characteristics,maternal thyroid function,scarred uterus,placenta previa and reproductive tract infection(P>0.05). Conclusions The neonatal head circumference is influenced by many factors.When formulating the reference range of normal birth head circumference,In addition to considering the differences of physiological factors,it is supposed to exclude samples of related disease factors,such as intrauterine growth restriction,pregnancy complications(gestational diabetes mellitus,hypertension,cholestasis and anemia),abnormal amniotic fluid,umbilical cord abnormalities and so on,so that the scientificity of the reference range can be ensured.

Key words: head circumference, influencing factors, cross-sectional study