脐血血清促代谢因子水平与胎儿生长发育的关系

doi:10.11852/zgetbjzz2019-0112

中国儿童保健杂志 ›› 2019, Vol. 27 ›› Issue (10): 1075-1078.DOI: 10.11852/zgetbjzz2019-0112

脐血血清促代谢因子水平与胎儿生长发育的关系

郑俊虎¹, 潘益匆¹, 柯汝淑², 陈洪³, 邹跃玲³, 胡晓娜⁴, 王大化¹, 钱定良⁵

瑞安市人民医院妇幼分院 1 新生儿科;
2 妇产科;
3 检验科;
4 分娩室,浙江瑞安 325200;
5 瑞安市人民医院检验科,浙江瑞安 325200

收稿日期:2019-01-25 发布日期:2019-10-10 出版日期:2019-10-10
作者简介:郑俊虎(1975-),男,浙江人,主任医师,医学学士,主要研究方向为新生儿疾病。
基金资助:
温州市科技计划项目(Y20170638)

Relationship between serum betatrophin in cord blood and growth development of fetus

ZHENG Jun-hu¹, PAN Yi-cong¹, KE Ru-shu², CHEN Hong³, ZOU Yue-ling³, HU Xiao-na⁴, WANG Da-hua¹, QIAN Ding-liang⁵

1 Department of Neonatology;
2 Department of Obstetrics and Gynecology;
3 Clinical Laboratory;
4 Delivery Room, Maternal and Child Brand of Ruian Peoples′s Hospital, Ruian,Zhejiang 325200,China;
5 Clinical Laboratory Department of Ruian Peoples′s Hospital, Ruian,Zhejiang 325200,China

Received:2019-01-25 Online:2019-10-10 Published:2019-10-10

摘要/Abstract

摘要： 目的探讨脐血血清促代谢因子(betatrophin)水平与胎儿生长发育的关系,为胎儿保健提供依据。方法 2018年1-7月选择瑞安市人民医院妇幼分院出生的大于胎龄儿(LGA)、适于胎龄儿(AGA)和小于胎龄儿(SGA)各30例。检测脐血、母血和羊水betatrophin水平,分析脐血血清betatrophin水平与胎儿生长发育各指标、糖脂代谢指标、瘦素和脂联素等的相关性。结果 LGA、AGA、SGA的脐血血清betatrophin水平分别为(1 009.210±98.761)、(929.487±80.949)、(910.590±105.518)ng/L,差异有统计学意义(F=8.986,P＜0.001);三组新生儿血脂各指标水平比较差异均无统计学意义(P>0.05);相关分析显示脐血betatrophin水平与新生儿出生体重、重量指数(PI)、胎龄,脐血瘦素、甘油三酯水平呈正相关(r=0.537、0.502、0.250、0.422、0.832,P＜0.05),与脐血脂联素水平呈负相关(r=-0.257、P＜0.05),与母血和羊水betatrophin水平,孕前和分娩时体重量、孕前体重指数(BMI)、孕期体重指数增加量(ΔBMI),胎盘重量,脐血和产妇血糖(PG)、胰岛素(INS)、胰岛素抵抗指数(HOMA-IR)无相关性(P>0.05);多元线性回归分析显示血betatrophin是新生儿出生体重独立影响因素(P＜0.05)。结论 Betatrophin参与胎儿生长发育调节,脐血betatrophin水平可反映胎儿的生长发育状况。

关键词: 促代谢因子, 胎儿, 血脂, 重量指数, 脐血

Abstract: Objectives To investigate the relationship between serum betatrophin and growth development among fetus,in order to provide reference for fetal healthcare. Methods Totally 30 large for gestational age(LGA)infants,30 appropriate for gestational age(AGA) infants and 30 small for gestational age(SGA) infants were enrolled in this study in Maternal and Child Health Hospital of Ruian People′s Hospital from January to July 2018. Serum betatrophin level in cord blood,maternal blood and amniotic fluid was tested,and the relationships among betatrophin in cord blood,indexes of fetal growth and development,glucose and lipid metabolic parameters,insulin resistance,leptin and serum adiponectin were analyzed. Results The serum betatrophin levels in cord blood of LGA,AGA and SGA were (1 009.210±98.761) ng/L,(929.487±80.949) ng/L and (910.590±105.518) ng/L respectively,with significant difference among three groups(F=8.986,P<0.001). There were no significant differences on lipid indexes among LGA,AGA and SGA infants(P>0.05). Pearson correlation analysis indicated that serum betatrophin level in cord blood was positively correlated with birth weight,ponderal index(PI) and gestational age of neonates,leptin and triglyceride(TG) in cord blood(r=0.537,0.502,0.250,0.422,0.832,P<0.05),and negative correlation was found between serum betatrophin and adiponectin level in cord blood(r=-0.257,P<0.05).However,there were no significant correlations between serum betatrophin level and betatrophin level in maternal blood or amniotic fluid,body weight before pregnancy and delivery,pre-pregnancy BMI,BMI increase during pregnancy,placental weight,plasma glucose(PG),insulin(INS) and HOMA-IR in cord and maternal blood(P>0.05). Multivariate linear regression analysis showed that blood betatrophin was an independently influencing factor for neonatal birth weight(P＜0.05). Conclusions Betatrophin level of cord blood is related to the adjustment of fetal growth. On the other hand,betatrophin level can reflect the status of feta1 growth and development.

Key words: betatrophin, fetus, blood lipid, ponderal index, cord blood

中图分类号:

R722.6

郑俊虎, 潘益匆, 柯汝淑, 陈洪, 邹跃玲, 胡晓娜, 王大化, 钱定良. 脐血血清促代谢因子水平与胎儿生长发育的关系[J]. 中国儿童保健杂志, 2019, 27(10): 1075-1078.

ZHENG Jun-hu, PAN Yi-cong, KE Ru-shu, CHEN Hong, ZOU Yue-ling, HU Xiao-na, WANG Da-hua, QIAN Ding-liang. Relationship between serum betatrophin in cord blood and growth development of fetus[J]. journal1, 2019, 27(10): 1075-1078.

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脐血血清促代谢因子水平与胎儿生长发育的关系

Relationship between serum betatrophin in cord blood and growth development of fetus

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