关键词: 同型半胱氨酸, 单纯肥胖症儿童, 心血管疾病, 糖尿病

Abstract: Objectives To investigate the relationship between serum Hcy and the risk of diabetes mellitus and cardiovascular disease in simple obese children,in order to provide reference for clinical diagnosis and treatment of simple obesity in chidren. Methods Totally 53 simple obese children who visited in Shenzhen children′s Hospital were enrolled in obesity group from August 2016 to December 2017,and 82 healthy children who underwent physical examination in this hospital during the same period were selected as normal group. Serum homocysteine(Hcy) level was determined by chemiluminescence. Height,weight,hip circumference,waist circumference,body mass index(BMI),waist-hip ratio(WHR),total cholesterol(TC),triglyceride(TG),high density lipoprotein(HDL-C),low density lipoprotein(LDL-C),fasting blood glucose(FBG) and fasting insulin(FINS) were measured,and insulin secretion function index(HOMA-β),homeostasis model insulin resistance index(HOMA-IR) were calculated. Also,the correlation between Hcy and other indicators was analyzed. Results The level of serum Hcy in obesity group was significantly higher than that in normal group(t=3.136,P<0.05). There was no significant difference in height between the two groups(P>0.05),while the body weight,hip circumference,waist circumference,BMI and WHR in obesity group were higher than those of the normal group(P<0.05). Moreover,the levles of FBG,FINS and HOMA-IR in simple obese children were significantly higher than those of normal group,while the level of HOMA-β was significantly lower in simple obese children(P<0.05). Serum Hcy level was positively correlated with BMI,WHR,FBG,FINS,HOMA-IR,TG,TC and LDL-C levels(r=0.473—0.732,P< 0.05),and negatively related to HOMA-beta and HDL-C levels(r=-0.774,-0.725,P<0.05). Conclusion Serum homocysteine level is increasing in simple obese children,which is closely correlated with diabetes mellitus and cardiovascular disease.So it is suggested that serum homocysteine level should be monitored regularly in simple obese children.

Key words: homocysteicacid, simpleobesechildren, cardiovasculardisease, diabetesmellitus