注意缺陷多动障碍儿童睡眠问题的研究进展

doi:10.11852/zgetbjzz2019-0964

摘要/Abstract

摘要： 注意缺陷多动障碍(ADHD)是儿童青少年常见的神经发育障碍性疾病,主要表现为与年龄发育不相称的注意力不集中、多动和/或冲动。ADHD易共患其他疾病,其中睡眠问题日益受到关注。患有睡眠问题的ADHD患儿可能会导致更加严重的功能障碍,影响情绪、注意力、行为,最终影响学校或者工作表现和生活质量。本文主要从ADHD患儿常见的睡眠问题、ADHD共患睡眠问题的病理机制及药物治疗对ADHD患儿睡眠的影响三个方面进行综述,以提高人们对二者之间联系的认识。

关键词: 注意缺陷多动障碍, 睡眠问题, 儿童

Abstract: Attention deficit/hyperactivity disorder (ADHD) is a common behavioral development disorder in children and adolescents,mainly characterized by inattention not matched with one′s age, hyperactivity and/or impulsivity.ADHD is easy to co-occur with other diseases, of which sleep problems have been paid increasing attention to in recent years.Children with both ADHD and sleep problems may cause more severe functional disorders, affecting mood, attention, behavior, and ultimately affecting school or work performance and quality of life.This article mainly reviews the common sleep problems of ADHD children,the pathological mechanism of ADHD comorbid sleep problems and the effects of medication on sleep in ADHD children so as to improve people′s understanding the relationship of the two.

Key words: attention deficit/hyperactivity disorder, sleep problems, children

中图分类号:

R749.94

陈冯凤, 王瑜. 注意缺陷多动障碍儿童睡眠问题的研究进展[J]. 中国儿童保健杂志, 2020, 28(4): 423-426.

CHEN Feng-feng, WANG Yu. Progress in sleep research in children with attention deficit/hyperactivity disorder[J]. journal1, 2020, 28(4): 423-426.

参考文献

[1] 静进.儿童注意缺陷多动障碍诊疗进展[J].中华实用儿科临床杂志,2012,27(12):965-970.
[2] Wang T, Liu K, Li Z, et al.Prevalence of attention deficit/hyperactivity disorder among children and adolescents in China:a systematic review and meta-analysis[J].Bmc Psychiatry,2017,17(1):32.
[3] Efron D, Lycett K, Sciberras E.Use of sleep medication in children with ADHD[J].Sleep Medicine,2014,15(4):472-475.
[4] Hvolby A.Associations of sleep disturbance with ADHD:implications for treatment[J].Atten Defic Hyperact Disord,2015,7(1):1-18.
[5] Spruyt K, Gozal D.Sleep disturbances in children with attention-deficit/hyperactivity disorder[J].Expert Rev Neurother,2011,11(4):565-577.
[6] Schneider HE, Lam JC,Mahone EM .Sleep disturbance and neuropsychological function in young children with ADHD[J].Child Neuropsychol,2016,22(4):493-506.
[7] Langberg JM,Molitor SJ, Oddo LE, et al.Prevalence, patterns, and predictors of sleep problems and daytime sleepiness in young adolescents with ADHD[J].J Atten Disord,2017.doi:10.1177/1087054717690810.
[8] 朱冬梅,鲁格兰,张海燕,等.儿童注意缺陷多动障碍与睡眠问题的相关性探讨[J].临床荟萃,2012,27(23):2074-2076.
[9] 陈宝君,王利刚,陶婷,等.3～10岁儿童注意缺陷多动症状的发生状况及其与睡眠的关系[J].中华行为医学与脑科学杂志,2014,23(7):632-635.
[10] 张红艳.注意缺陷多动障碍儿童睡眠与情绪行为问题的相关性研究[D].衡阳:南华大学,2017:1-58.
[11] Sung V, Hiscock H,Sciberras E, et al.Sleep problems in children with attention-deficit/hyperactivity disorder:prevalence and the effect on the child and family[J].Arch Pediatr Adolesc Med,2008,162(4):336.
[12] 韩芳,陈宝元.关注常见呼吸疾病的睡眠与睡眠呼吸问题[J].中华医学杂志,2019,99(6):401-403.
[13] Youssef NA,Ege M, Angly SS, et al.Is obstructive sleep apnea associated with ADHD?[J].Ann Clin Psychiatry,2011,23(3):213-224.
[14] Henriques Filho Paulo Sérgio Azeredo.Sleep disorder investigation might be considered to be mandatory in attention deficit/hyperactivity disorder guideline[J].Arq Neuropsiquiatr,2016,74(9):701-707.
[15] 吴佳欐.阻塞性睡眠呼吸暂停低通气综合征患儿中合并注意缺陷多动障碍相关因素分析[D].上海:上海交通大学,2016:1-74.
[16] Wajszilber D, Santiseban JA, Gruber R.Sleep disorders in patients with ADHD:impact and management challenges[J].Nat Sci Sleep,2018,10:453-480.
[17] Daubian-Nosé P, Frank MK, Esteves AM.Sleep disorders:a review of the interface between restless legs syndrome and iron metabolism[J].Sleep Science,2014,7(4):234-237.
[18] 万齐华,张伟,王莞尔,等.发作性睡病合并精神分裂症的研究进展[J].中华医学杂志,2019,99(3):238-240.
[19] Ohayon, Maurice M .Narcolepsy is complicated by high medical and psychiatric comorbidities:a comparison with the general population[J].Sleep Medicine,2013,14(6):488-492.
[20] 冯军坛,朱彦丽,王立文,等.注意缺陷多动障碍儿童的睡眠结构研究[J].中国实用儿科杂志,2007,22(8):624-626.
[21] 吕凌云,张建昭,刘肖予,等.注意缺陷多动障碍儿童睡眠结构变化[J].中华实用儿科临床杂志,2015,30(24):1877-1879.
[22] Cortese S, Faraone SV, Konofal E, et al.Sleep in patterns, and predictors of sleep problems and daytime sleepiness in young adolescents with[J].J Am Acad Child Adolesc Psychiatry,2009,48(9):894-908.
[23] Kirov R,Kinkelbur J, Banaschewski T, et al.Sleep patterns in children with attention-deficit/hyperactivity disorder, tic disorder, and comorbidity[J].J Child Psychol Psychiatry,2010,48(6):561-570.
[24] 曹银利,崔勤涛,唐成和,等.CLOCK基因T3111C多态性与儿童注意缺陷多动障碍及相关睡眠障碍的关联研究[J].中国当代儿科杂志,2012,14(4):285-288.
[25] 金嘉郦,刘璐,李海梅,等.昼夜节律钟基因多态性与儿童注意缺陷多动障碍及睡眠问题的相关分析[J].中华精神科杂志,2016,49(3):136-141.
[26] Marina X,Mara H. Polymorphisms in attention-deficit/hyperactivity disorder (ADHD):further evidence linking sleep and circadian disturbances and ADHD[J].Genes(Basel),2019,10(2):88.
[27] Abou-Khadra MK, Amin OR, Shaker OG,et al.Parent-reported sleep problems, symptom ratings, and serum ferritin levels in children with attention-deficit/hyperactivity disorder:a case control study[J].BMC Pediatrics,2013,13:217.
[28] 陈湘红,张利之,杨春柳.注意缺陷多动障碍儿童睡眠障碍与铁缺乏关系的临床研究[J].现代生物医学进展,2011,11(10):1937-1939.
[29] Konrad K,Eickhoff SB.Is the ADHD brain wired differently? A review on structural and functional connectivity in attention deficit hyperactivity disorder[J].Human Brain Mapping,2010,31(6):904-916.
[30] 钱安丹.DRD4基因多态性对ADHD患儿大脑静息态异常脑网络连接的研究[D].温州:温州医科大学,2017:1-40.
[31] 宋志远,易红良.多巴胺与睡眠呼吸障碍研究进展[J].中华耳鼻咽喉头颈外科杂志,2017,52(7):549-551.
[32] 郭平,杜亚松,郭华.儿童注意缺陷多动障碍的病因学及治疗研究进展[J].心理医生,2017,23(30):2-3.
[33] Visser SN, Danielson ML, Bitsko RH, et al.Trends in the parent-report of health care provider-diagnosed and medicated attention-deficit/hyperactivity disorder:United States,2003-2011[J].J Am Acad Child Adolesc Psychiatry,2014,53(1):34-46.
[34] Corkum P.Response:"acute impact of immediate release methylphenidate administered three times a day on sleep in children with attention-deficit/hyperactivity disorder"[J].J Pediatr Psychol,2008,33(4):368.
[35] Chin WC,Huang YS,Chou YH,et al.Subjective and objective assessments of sleep problems in children with attention deficit/hyperactivity disorder and the effects of methylphenidate treatment.[J].Biomed J,2018,41(6):356-363.
[36] Sangal RB, Owens J, Allen AJ, et al.Effects of atomoxetine and methylphenidate on sleep in children with ADHD[J].Sleep,2006,29(12):1573-1585.
[37] Kidwell KM,Dyk TRV, Alyssa L, et al.Stimulant medications and sleep for youth with ADHD:a Meta-analysis[J].Pediatrics,2015,136(6):1144-1153.