鼻用激素与孟鲁司特钠联合对腺样体肥大患儿睡眠质量及临床疗效的影响

doi:10.11852/zgetbjzz2021-1377

中国儿童保健杂志 ›› 2022, Vol. 30 ›› Issue (1): 93-96.DOI: 10.11852/zgetbjzz2021-1377

鼻用激素与孟鲁司特钠联合对腺样体肥大患儿睡眠质量及临床疗效的影响

陈谊辉¹, 杨爱叶², 陈鹏¹, 杨引通¹

1.西安市第四医院耳鼻喉科,陕西西安 710004;
2.西安交通大学第二附属医院

收稿日期:2021-09-07 修回日期:2021-09-27 发布日期:2022-02-15 出版日期:2022-01-10
作者简介:陈谊辉(1965-),男,浙江人,副主任医师,主要研究方向为头颈肿瘤的综合治疗。

Effect of nasal hormone and montelukast sodium in the treatment of children with adenoid hypertrophy on sleep quality and clinical efficacy

CHEN Yi-hui^*, YANG Ai-ye, CHEN Peng, YANG Yin-tong

^*Department of Otolaryngology, the Fourth Hospital of Xi'an, Xi'an, Shaanxi 710004,China

Received:2021-09-07 Revised:2021-09-27 Online:2022-01-10 Published:2022-02-15

摘要/Abstract

摘要： 目的分析鼻用激素与孟鲁司特钠联合应用对腺样体肥大患儿睡眠质量和临床疗效的影响,为临床诊治提供参考依据。方法收集2019年12月—2020年12月间本院收治的400例腺样体肥大患儿,根据随机数字表法分为两组,对照组200例予以鼻用激素治疗,观察组200例予以鼻用激素与孟鲁司特钠联合治疗,8周后观察两组患儿的睡眠质量及临床疗效。结果治疗8周后,观察组患儿的总有效率为92.5%,高于对照组(85.0%)(χ²=5.634,P＜0.05);观察组睡眠障碍评分为(5.17±1.05)分 ,A/N值为(0.60±0.05),分别比对照组的(6.60±1.38)及(0.70±0.06)分低(t=11.662,18.107,P＜0.05);观察组的血清白细胞介素-6(IL-6)、白细胞介素-4(IL-4)及白细胞介素-1β(IL-1β)水平均以及嗜酸性粒细胞(EOS)计数、变应原特异性IgE(sIgE)、嗜酸性细胞阳离子蛋白(ECP)表达低于对照组(t=30.936、13.248、19.718、23.190、10.304、39.316,P＜0.05)。结论鼻用激素与孟鲁司特钠联合应用可以改善腺样体肥大患儿的睡眠质量,有助于提升其临床疗效,值得临床推广使用。

关键词: 鼻用激素, 孟鲁司特钠, 腺样体肥大, 睡眠质量, 血清炎性因子, 血清变态反应

Abstract: Objective To analyze the effects of nasal hormones and montelukast sodium in the treatment of children with adenoid hypertrophy on sleep quality and clinical efficacy, so as to provide reference for clinical diagnosis and treatment. Methods A total of 400 cases of children with adenoid hypertrophy admitted to the Department of Otolaryngology, the Fourth Hospital of Xi'an from December 2019 to December 2020 were selected into this study, and were randomly divided into two groups according to the random number table method, with 200 cases in each group. The control group was treated with nasal hormones, and the observation group received nasal hormones and montelukast sodium treatment. The clinical efficacy, sleep quality of the two groups were observed in 8 weeks. Results After 8 weeks of treatment, the total effective rate of children in the observation group was significantly higher than that in the control group (92.5% vs. 85.00%, χ²=5.634,P<0.05). The score of sleep disorder was 5.17±1.05 and the A/N value was 0.60±0.05, significantly lower than those of the control group (6.60±1.38, 0.70±0.06, t=11.662, 18.107, P<0.05). Moreover, serum levels of IL-6, IL-4 and IL-1β, the EOS count,the expression levels of sIgE andeosinophil cationic protein(ECP) were significantly lower than those of the control group (t=30.936, 13.248, 19.718, 23.190, 10.304, 39.316, P<0.05). Conclusion The combination of nasal hormone and montelukast sodium has a significant effect in children with adenoid hypertrophy, which helps to improve the sleep quality and curative effect of children, and is worth in promoting clinically.

Key words: nasal hormones, montelukast sodium, adenoid hypertrophy, sleep quality, serum inflammatory factors, serum allergy

中图分类号:

R766

陈谊辉, 杨爱叶, 陈鹏, 杨引通. 鼻用激素与孟鲁司特钠联合对腺样体肥大患儿睡眠质量及临床疗效的影响[J]. 中国儿童保健杂志, 2022, 30(1): 93-96.

CHEN Yi-hui, YANG Ai-ye, CHEN Peng, YANG Yin-tong. Effect of nasal hormone and montelukast sodium in the treatment of children with adenoid hypertrophy on sleep quality and clinical efficacy[J]. Chinese Journal of Child Health Care, 2022, 30(1): 93-96.

参考文献

[1] Yi XL, Yao LY, Zhao PF, et al. Development patterns of adenoids in Chinese children without sleep-disordered breathing: A retrospective magnetic resonance imaging study with consecutive age groups[J].Chinese Med J,2021,134(12):1500-1502.
[2] 刘燕,魏萍,寇巍,等.儿童腺样体肥大与耳鼻咽喉科常见疾病关系的研究进展[J].山东大学耳鼻喉眼学报,2019,33(4):155-160.
[3] 丁锋,王然然,徐宝丽,等.糠酸莫米松鼻喷雾剂联合鼻渊通窍颗粒治疗儿童腺样体肥大疗效观察[J].儿科药学杂志,2019,25(1):23-26.
[4] 楼响瑜,李勇,滕尧树,等.高渗海水联合鼻用糖皮质激素治疗儿童腺样体肥大的疗效[J].中国眼耳鼻喉科杂志,2019,19(6):418-421.
[5] Luo H, Han H, Liu X, et al. Efficacy and safety of montelukast sodium combined with fluticasone in the treatment of adult bronchial asthma: a protocol for systematic review and meta-analysis[J].Medicine,2020,99(52):e23453.
[6] 江载芳,申昆玲,沈颖.诸福棠实用儿科学[M].8版.北京:人民卫生出版社,2015:2546-2547.
[7] 孙书臣,马彦,乔静,等.儿童腺样体肥大引发睡眠呼吸障碍的中医诊疗专家共识[J].世界睡眠医学杂志,2014,1(6):321-325.
[8] 邱立志,蒲海波,杨传楹.清腺方联合辅舒良鼻喷剂治疗儿童腺样体肥大的效果及对睡眠质量,呼吸功能的影响[J].中华中医药学刊,2019,37(7):1771-1773.
[9] 冯丽,刘涛,周洁,等.眼耳鼻喉疾病诊疗学[M].天津:科学技术出版社,2012:23-25.
[10] Xiao H, Huang J, Liu W, et al. The cost-effectiveness analysis of drug therapy versus surgery for symptomatic adenoid hypertrophy by a Markov model[J].Qual Life Res,2020,29(Suppl 4):1-3.
[11] 熊升华,黄从付,杨贵,等.两种不同方法治疗儿童腺样体肥大的临床对照研究[J].儿科药学杂志,2020,26(10):33-36.
[12] 杨颖,王骏,勇刚,等.孟鲁司特钠片联合布地奈德鼻喷雾剂治疗过敏性鼻炎临床探讨[J].山西医药杂志,2019,48(9):70-72.
[13] 廖世峨,魏兵,马明,等.白三烯C4合成酶基因多态性与儿童哮喘易感性及孟鲁司特疗效关联研究[J].中国儿童保健杂志,2018,26(8):29-32,36.
[14] 孙小燕,毛庆杰,范红梅,等.鼻内镜下切割吸引刀与腺样体刮勺盲刮治疗腺样体肥大的疗效比较[J].安徽医学,2019,40(10):1095-1098.
[15] 林小燕,范穗强,杜钢,等.孟鲁司特钠联合左卡巴斯汀鼻喷剂治疗小儿过敏性鼻炎的疗效评价及对血清ECP,EOS及CRP水平的影响[J].现代生物医学进展,2019,19(17):73-76,188.

鼻用激素与孟鲁司特钠联合对腺样体肥大患儿睡眠质量及临床疗效的影响

Effect of nasal hormone and montelukast sodium in the treatment of children with adenoid hypertrophy on sleep quality and clinical efficacy

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 13

编辑推荐

Metrics

[1]	彭莲华, 刘冬冬, 朱肖, 姜珊, 徐萍, 毛平. 睡眠质量和抑郁在童年不良经历青少年神经质人格与执行功能之间的链式中介作用[J]. 中国儿童保健杂志, 2022, 30(8): 851-855.
[2]	董明瑛, 陶炳铜. 白三烯C4合成酶基因多态性与呼吸道合胞病毒毛细支气管炎易感性及疗效的相关性[J]. 中国儿童保健杂志, 2021, 29(5): 545-549.
[3]	陈冯凤, 韦念堇, 马晨欢, 潘丽珠, 王瑜. 注意缺陷多动障碍儿童睡眠质量问题调查研究[J]. 中国儿童保健杂志, 2021, 29(1): 67-70.
[4]	朱庆庆, 花静, 杨青. 上海市早产儿学龄前期睡眠质量状况调查[J]. 中国儿童保健杂志, 2020, 28(9): 1013-1016.
[5]	蒋琳, 马颖, 邢艳菲, 林穗方. 学龄前儿童电子媒体的使用与睡眠模式及质量的相关性研究[J]. 中国儿童保健杂志, 2020, 28(5): 574-578.
[6]	张琦一, 武敏, 王嘉琪, 荚婉茹, 沈杰, 张晓燕, 蔺婧. 体位性心动过速综合征患儿唾液皮质醇水平与睡眠质量及临床症状严重程度的相关性分析[J]. 中国儿童保健杂志, 2020, 28(4): 379-384.
[7]	刘美燕, 郭倩雯, 吴丹, 汪秀莲, 梁滔, 孙凡凡, 兰红艳, 陈津津. 学龄前儿童运动与睡眠质量的关联研究[J]. 中国儿童保健杂志, 2020, 28(10): 1097-1100.
[8]	张宝, 徐慧琼, 汪姗姗, 宋先兵, 万宇辉. 睡眠质量在童年期不良经历与中学生抑郁症状关联中的中介作用及性别差异[J]. 中国儿童保健杂志, 2019, 27(9): 958-961.
[9]	程玮,王贞,王静,闫堃. 对氧磷酶2与白三烯受体在儿童支气管哮喘中表达的相关性及临床生物学意义[J]. 中国儿童保健杂志, 2017, 25(8): 843-845.
[10]	林林,满丰韬,胡乃宝,刘海霞,贾改珍,王萍玉. 青少年近视的危险因素研究[J]. 中国儿童保健杂志, 2013, 21(2): 206-209.
[11]	孙莞绮,姜艳蕊,陈文娟,王燕,李峰,李生慧,颜崇淮,金星明,沈晓明,江帆. 周末补偿睡眠对学龄儿童睡眠质量和学业表现的影响[J]. 中国儿童保健杂志, 2012, 20(9): 783-786.
[12]	刘敏娜,肖琳,高雪婷,雷琰,黄哲. 西安市婴儿睡眠问题与母亲睡眠质量和情绪的相关性研究[J]. 中国儿童保健杂志, 2012, 20(9): 790-793.
[13]	赵茜叶,宋继成. 孟鲁司特对呼吸递合胞病毒毛细支气管炎患儿血清白介素-5及嗜酸粒细胞趋化蛋白表达的影响[J]. 中国儿童保健杂志, 2011, 19(2): 182-184.