关键词: 杜氏肌营养不良症, 运动功能, 运动功能测试, 肌肉力量

Abstract: Objective To investigate the correlation of motor function with muscle strength and age in children with Duchenne muscular dystrophy (DMD), so as to provide theoretical reference for better management of DMD. Methods DMD Children in Shenzhen Children's Hospital from January 2017 to March 2021 were enrolled in this study, and were assessed by Motor Function Measure (MFM-32), timing tests (supine standing test, upper 4-step step test, 10 meter walk/run test), Vignos score, Brooke score and Manual Muscle Testing.Spearman correlation test was used to analyze the relationship between scores of MFM-32 and other indexes.Besides, the association of age with motor function and muscle strength was analyzed. Results A total of 140 DMD children aged 4 to 12 years were enrolled in this study, with an average age of (8.0±1.87) years old.The total score and D1 subscale of the MFM-32 were strongly correlated with muscle strength, timing test and Vignos score (r=-0.887 - 0.677,P<0.05).The score of D2 subscale was moderately correlated with timing test (r=-0.478 - -0.423,P<0.05), while the score of D3 subscale was not correlated with these measures (P＞0.05).Children's age was moderately associated with MFM-32 score, score of D1 subscale and the whole body muscle strength (r=-0.585 - -0.468,P<0.05).However, it appeared to be not correlated with the score of D2 subscale (P＞0.05), and was slightly correlated with the score of D3 subscale (r =0.317, P<0.05). Conclusions The scores of MFM-32 correlate with whole body muscle strength, timing test, Vignos score and Brooke score to different degrees, which can reflect the motor function of DMD children.The lower limb motor function of DMD children during childhood decreases significantly, and should be given priority to strengthen their lower extremity motor function and muscle strength.

Key words: Duchenne muscular dystrophy, motor function, Motor Function Measure, muscle strength