学龄前正常儿童应用事件相关电位N400的探索性研究

doi:10.11852/zgetbjzz2021-1008

中国儿童保健杂志 ›› 2022, Vol. 30 ›› Issue (3): 268-271.DOI: 10.11852/zgetbjzz2021-1008

学龄前正常儿童应用事件相关电位N400的探索性研究

朱一可¹, 尹悦¹, 刘思奇¹, 张樊¹, 王小月¹, 任永颖¹, 孙静¹, 王昕¹, 王琳², 杨健¹

1.首都儿科研究所附属儿童医院神经内科,北京 100020;
2.首都儿科研究所附属儿童医院保健科

收稿日期:2021-07-01 修回日期:2021-09-01 发布日期:2022-03-18 出版日期:2022-03-10
通讯作者: 杨健,E-mail:yangjian1306@sina.com
作者简介:朱一可(1995-),女,湖北人,硕士研究生在读,主要从事神经电生理及神经发育障碍疾病的研究。
基金资助:
国家重点研发计划(2016YFC1306204);首都卫生发展科研专项项目(首发2020-1-4111)

Exploration of the N400 event-related potential in normal preschool children

ZHU Yi-ke^*, YIN Yue, LIU Si-qi, ZHANG Fan, WANG Xiao-yue, REN Yong-ying, SUN Jing, WANG Xin, WANG Lin, YANG Jian

^*Department of Neurology, Children's Hospital Affiliated to Capital Institute of Pediatrics, Beijing 100020, China

Received:2021-07-01 Revised:2021-09-01 Online:2022-03-10 Published:2022-03-18
Contact: YANG Jian, E-mail: yangjian1306@sina.com

摘要/Abstract

摘要： 目的了解学龄前正常儿童事件相关电位N400潜伏期、波幅特点和发展规律,为早期发现学龄前儿童语言认知功能障碍提供客观依据。方法对2015年8月-2020年1月健康体检的220例3～5岁学龄前正常儿童进行事件相关电位检测,采用声影匹配任务刺激,记录头皮电极Fz、Cz和Pz点N400的潜伏期和波幅。其中对127例记录了F3、F4点N400的潜伏期和波幅。结果学龄前正常儿童3～5岁组N400的潜伏期随年龄增加有逐渐缩短的趋势,但其差异无统计学意义(P >0.05);N400的波幅存在随着年龄增长逐渐降低的趋势,在Fz点和Cz点3岁～组和4岁～组 [ Fz点(-10.95±9.78) vs.(-6.40±6.53)μV, Cz点(-12.48±9.45) vs.(-7.71±7.80)μV] 、3岁～组和5岁～组[Fz点(-10.95±9.78) vs.(-7.01±7.47)μV,Cz点(-12.48±9.45) vs.(-7.62±7.90)μV]的差异有统计学意义(P < 0.05)。性别和左右侧对学龄前儿童N400潜伏期和波幅的影响不显著(P >0.05)。结论学龄前儿童的N400波形清晰稳定,潜伏期和波幅随着年龄增长而变化。

关键词: 事件相关电位, N400, 学龄前儿童

Abstract: Objective To study the latency, waveform characteristics and development of the N400 component of event-related potential in normal preschool children, so as to provide Objective indicators for early detection of language cognitive impairment in preschool children. Methods A total of 220 normal preschool children aged 3 to 5 years who took physical examination from August 2015 to January 2020 performed sound and shadow matching tasks, and event-related potentials were tested, then the latency and amplitude of N400 in scalp electrodes F_Z, C_Z, and P_Z were recorded.The latency and amplitude of N400 in F3 and F4 were recorded in 127 cases. Results The latency of N400 in 3- to 5-year-old children showed a decreasing trend gradually with increasing age, but the difference was not statistically significant (P>0.05).The amplitude of N400 showed a tendency to decrease gradually with age, and the differences was significant in F_Z and C_Z between 3-year-old children and 4-year-old children [Fz: (-10.95±9.78)μV vs.(-6.40±6.53)μV,Cz: (-12.48±9.45)μV vs.(-7.71±7.80)μV], between 3-year-old children and 5-year-old children [Fz:(-10.95±9.78)μV vs.(-7.01±7.47)μV, Cz: (-12.48±9.45)μV vs.(-7.62±7.90)μV] (P<0.05).Effects of gender and lateralization on N400 latency and amplitude in preschool children were not significant (P>0.05). Conclusion The waveform of N400 is clear and stable in preschool children, with latency and amplitude changing with age.

Key words: event-related potential, N400, preschool children

中图分类号:

R748

朱一可, 尹悦, 刘思奇, 张樊, 王小月, 任永颖, 孙静, 王昕, 王琳, 杨健. 学龄前正常儿童应用事件相关电位N400的探索性研究[J]. 中国儿童保健杂志, 2022, 30(3): 268-271.

ZHU Yi-ke, YIN Yue, LIU Si-qi, ZHANG Fan, WANG Xiao-yue, REN Yong-ying, SUN Jing, WANG Xin, WANG Lin, YANG Jian. Exploration of the N400 event-related potential in normal preschool children[J]. Chinese Journal of Child Health Care, 2022, 30(3): 268-271.

参考文献

[1] Helfrich RF, Knight RT.Cognitive neurophysiology: Event-related potentials[J].Handb Clin Neurol, 2019, 160: 543-558.
[2] Kutas M, Federmeier KD.Thirty years and counting: Finding meaning in the N400 component of the event-related brain potential (ERP)[J].Annu Rev Psychol, 2011, 62: 621-47.
[3] Henderson LM, Baseler HA, Clarke PJ, et al.The N400 effect in children: Relationships with comprehension, vocabulary and decoding[J].Brain Lang, 2011, 117(2): 88-99.
[4] Rabovsky M, McRae K.Simulating the N400 ERP component as semantic network error: insights from a feature-based connectionist attractor model of word meaning[J].Cognition, 2014, 132(1): 68-89.
[5] Pijnacker J, Davids N, van Weerdenburg M, et al.Semantic processing of sentences in preschoolers with specific language impairment: Evidence from the N400 effect[J].J Speech Lang Hear Res, 2017, 60(3): 627-639.
[6] Wang S, Yang C, Liu Y, et al.Early and late stage processing abnormalities in autism spectrum disorders: An ERP study[J].PLoS One, 2017, 12(5): e0178542.
[7] Tiedt HO, Ehlen F, Klostermann F.Age-related dissociation of N400 effect and lexical priming[J].Sci Rep, 2020, 10(1): 20291.
[8] 李全业.正常和多动症儿童汉字认知的事件相关电位研究[D].苏州:苏州大学,2008.
[9] 赵方乔, 董选, 沈惠娟, 等.7～11岁注意缺陷多动障碍与正常儿童汉字语义加工发展的N400比较[J].中华行为医学与脑科学杂志, 2016, 25(3): 235-239.
[10] 尹悦,杨健.N400在小儿神经科的临床应用[J].中国妇幼保健, 2018, 33(17): 4073-4075.
[11] Morgan EU, van der Meer A, Vulchanova M, et al.Meaning before grammar: a review of ERP experiments on the neurodevelopmental origins of semantic processing[J].Psychon Bull Rev, 2020, 27(3): 441-464.
[12] Silva-Pereyra J, Rivera-Gaxiola M, Kuhl PK.An event-related brain potential study of sentence comprehension in preschoolers: semantic and morphosyntactic processing[J].Brain Res Cogn Brain Res, 2005, 23(2-3): 247-258.
[13] Khachatryan E, De Letter M, Vanhoof G, et al.Sentence context prevails over word association in aphasia patients with spared comprehension: Evidence from N400 event-related potential[J].Front Hum Neurosci, 2016, 10: 684.
[14] George SR, Taylor MJ.Somatosensory evoked potentials in neonates and infants: Developmental and normative data[J].Electroencephalogr Clin Neurophysiol, 1991, 80(2): 94-102.
[15] 杨先明.0-5岁汉语儿童语言发展的认知研究[D].武汉:武汉大学,2010.
[16] Kiang M, Gerritsen CJ.The N400 event-related brain potential response: A window on deficits in predicting meaning in schizophrenia.[J].Int J Psychophysiol, 2019, 145: 65-69.
[17] Cheyette SJ, Plaut DC.Modeling the N400 ERP component as transient semantic over-activation within a neural network model of word comprehension[J].Cognition, 2017, 162: 153-166.
[18] 彭聃龄.汉语认知研究[M].北京:北京师范大学出版社, 2006.
[19] Byrne JM, Connolly JF, MacLean SE, et al.Brain activity and language assessment using event-related potentials: Development of a clinical protocol[J].Dev Med Child Neurol, 1999, 41(11): 740-7.
[20] Mills DL, Neville HJ.Language comprehension and cerebral specialization from 13 to 20 months[J].Developmental Neuropsychology, 1997, 13(3): 397-445.
[21] Holcomb PJ, Cof Fe Y SA, Neville HJ.Visual and auditory sentence processing: A developmental analysis using event-related brain potentials[J].Developmental Neuropsychology, 1992, 8(2-3): 203-241.
[22] 静进.儿童言语及语言障碍的神经机制[J].中国儿童保健杂志, 2003,11(5): 323-327.

学龄前正常儿童应用事件相关电位N400的探索性研究

Exploration of the N400 event-related potential in normal preschool children

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