关键词: 喘息, 哮喘预测指数, 基因, 哮喘, 儿童

Abstract: Objective To explore the relationship between recurrent wheezing and gene prediction model of four-locus asthma in children, and to analyze the risk factors of recurrent wheezing. Methods A total of 91 asthmatic children who were hospitalized or saw a doctor in outpatient clinics in Yuhuan People's Hospital from January 2019 to March 2021 were selected into this study. According to the asthma predictive index(API) result, children were divided into API positive group(n=55) and API negative group(n=36).Meanwhile, 30 healthy children were selected as the control group. The high-risk rates of four-locus asthma gene prediction model among three groups were compared. The influencing factors of recurrent wheezing were analyzed by univariate and multivariate Logistic regression. Results The high-risk rate of four-locus asthma gene prediction model in API positive group was significantly higher than that in API negative group and control group(χ² =12.487, P<0.05). The risk of the four-locus asthma gene prediction model in the API positive group was 2.54 times higher than that in the API negative group and 5.32 times higher than that in the control group. Univariate analysis indicated that children's recurrent wheezing was associated with high risk type of the four-locus asthma gene prediction model, allergy history, family history of allergic diseases, positive inhaled allergens, positive ingested allergens, passive smoking, elevated eosinophil count and respiratory syncytial virus infection(χ²=13.831, 22.817, 25.475, 20.573, 6.373, 11.487, 10.790, 10.789, P<0.05), but not related to living surroundings(P>0.05). Multivariate Logistic regression analysis showed that the high risk type of four-locus asthma gene prediction model(OR=5.535, 95%CI: 1.928 -15.893), allergy history(OR=4.921, 95%CI:1.661 - 14.577), family history of allergic diseases(OR=4.460, 95%CI:1.560 - 12.749),positive inhaled allergens(OR=13.105, 95%CI:2.436 - 70.503) and passive smoking(OR=3.704, 95%CI:1.304 - 10.521) were independent risk factors for recurrent wheezing. Conclusions The high risk rate of four-locus asthma gene prediction model is significantly increased in children with recurrent wheezing, especially API positive children. Repeated wheezing is caused by multiple factors, among which the high risk type of four-locus asthma gene prediction model is an important reason.

Key words: wheezing, asthma predictive index, gene, asthma, children