关键词: 儿童, 先天性心脏病, 病例对照研究

Abstract: Objective To identify the non-genetic influencing factors of children with congenital heart disease (CHD) in Jilin, so as to provide reference for making targeted strategies to reduce the risk of CHD among children in Northeastern China. Methods Children with CHD identified in the birth defects reporting system of Jilin Province from 2019 to 2020 and their mothers who met the inclusion criteria and were willing to cooperate were selected as the case group. Meanwhile, healthy children with the same sex, age and region and their mothers were selected into the control group by 1∶2 case-control matching. Multivariate Logistic regression model was used to analyze the influencing factors of CHD in children. Results There were no significant differences between case group and control group in terms of gender and age distribution(P>0.05). Multivariate analysis showed that premature (OR=6.224), father drinking alcohol within 3 months before pregnancy (OR=2.476), maternal BMI ≥25 kg/m² before pregnancy(OR=8.372) were the risk factors for CHD in children, while multivitamin use during pregnancy(OR=0.342) was a protective factor of CHD in children. Conclusions Premature birth, father's alcohol consumption within 3 months before pregnancy and mother's pre-pregnancy BMI ≥25 kg/m² are risk factors for the development of CHD in children in Jilin. Therefore, the focus should be on cardiac function in preterm infants, strengthening education on health care for couples preparing for pregnancy, encouraging them to quit smoking and drinking, control weight, so as to take an active role in pregnancy care.

Key words: children, congenital heart disease, case control study