关键词: 低出生体重儿, 生长速度, 胰岛素敏感性, 婴儿期

Abstract: 【Objective】 To investigate the relationship between growth velocity and insulin sensitivity in low birth weight (LBW) infants during infancy. 【Methods】 LBW infants as LBW group and normal weight infants as control (normal control,NC) were recruited into the study and follow up one year.Seven hundred and sixty six subjects met the inclusion criteria and 628 infants finished the follow-up.Body weight,length,fasting glucose and fasting insulin (FI) levels were measured at 6 months and 12 months of age.Homeostasis model assessment (HOMA),ponderal index (PI) and body mass index (BMI) were calculated.Insulin sensitivity was evaluated by FI and HOMA. 【Results】 During infancy,although LBW infants had gained more weight and length,they had been lighter and smaller than NC infants.Body weight,body length and BMI of LBW group were significantly lower than NC group at each measurement.In LBW group,the changes of weight Z-score and height Z-score during infancy were larger than NC group.At 12 months,the FI and HOMA (logarithmically transformed) were significantly higher in LBW group. 【Conclusions】 In current study,although LBW infants have gained more weight and length,they have been lighter and smaller during infancy.Until the end of infancy,fasting insulin and HOMA suggest that LBW infants have relatively impaired insulin sensitivity.

Key words: low birth weight infants, growth velocity, insulin sensitivity, infancy