［1］Valdes AM, Walter J, Segal E, et al. Role of the gut microbiota in nutrition and health［J］. BMJ, 2018，361:k2179.
［2］Bull MJ, Plummer NT. Part 1: The human gut microbiome in health and disease［J］. Integr Med (Encinitas), 2014，13(6):17-22.
［3］Kamada N, Seo SU, Chen GY, et al. Role of the gut microbiota in immunity and inflammatory disease［J］. Nat Rev Immunol, 2013,13(5):321-335.
［4］Rooks MG, Garrett WS. Gut microbiota, metabolites and host immunity［J］. Nat Rev Immunol, 2016, 16(6):341-352.
［5］Koh A, De Vadder F, Kovatcheva-Datchary P, et al. From dietary fiber to host physiology: Short-chain fatty acids as key bacterial metabolites［J］. Cell, 2016, 165(6):1332-1345.
［6］Cummings JH, Pomare EW, Branch WJ, et al. Short chain fatty acids in human large intestine, portal, hepatic and venous blood［J］. GUT, 1987, 28(10):1221-1227.
［7］Morrison DJ, Preston T. Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism［J］. Gut Microbes, 2016, 7（3）:189-200.
［8］Flint HJ, Duncan SH, Scott KP, et al. Links between diet, gut microbiota composition and gut metabolism［J］. Proc Nutr Soc, 2015,74（1）:13-22.
［9］El KA, Armougom F, Gordon JI, et al. The abundance and variety of carbohydrate-active enzymes in the human gut microbiota［J］. Nat Rev Microbiol, 2013, 11（7）:497-504.
［10］Levy M, Thaiss CA, Elinav E. Metabolites: messengers between the microbiota and the immune system［J］. Genes Dev, 2016, 30（14）:1589-1597.
［11］Ragsdale SW, Pierce E. Acetogenesis and the wood-ljungdahl pathway of CO(2) fixation［J］. Biochim Biophys Acta, 2008,1784（12）:1873-1898.
［12］Hetzel M, Brock M, Selmer T, et al. Acryloyl-CoA reductase from Clostridium propionicum. An enzyme complex of propionyl-CoA dehydrogenase and electron-transferring flavoprotein［J］. Eur J Biochem, 2003, 270（5）:902-910.
［13］Scott KP, Martin JC, Campbell G, et al. Whole-genome transcription profiling reveals genes up-regulated by growth on fucose in the human gut bacterium "Roseburia inulinivorans"［J］. J Bacteriol, 2006, 188（12）:4340-4349.
［14］Louis P, Duncan SH, McCrae SI, et al. Restricted distribution of the butyrate kinase pathway among butyrate-producing bacteria from the human colon［J］. J Bacteriol, 2004, 186（7）:2099-2106.
［15］Duncan SH, Barcenilla A, Stewart CS, et al. Acetate utilization and butyryl coenzyme A (CoA):acetate-CoA transferase in butyrate-producing bacteria from the human large intestine［J］. Appl Environ Microbiol, 2002, 68（10）:5186-5190.
［16］Vital M, Howe AC, Tiedje JM. Revealing the bacterial butyrate synthesis pathways by analyzing (meta)genomic data［J］. MBio, 2014, 5（2）:e889.
［17］Donohoe DR, Collins LB, Wali A, et al. The Warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation［J］. Mol Cell, 2012, 48（4）:612-626.
［18］van der Beek CM, Bloemen JG, van den Broek MA, et al. Hepatic uptake of rectally administered butyrate prevents an increase in systemic butyrate concentrations in humans［J］. J Nutr, 2015,145（9）: 2019-2024.
［19］Bloemen JG, Venema K, van de Poll MC, et al. Short chain fatty acids exchange across the gut and liver in humans measured at surgery［J］. Clin Nutr, 2009, 28（6）:657-661.
［20］Morrison DJ, Preston T. Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism［J］. Gut Microbes, 2016, 7（3）:189-200.
［21］Kamada N, Seo SU, Chen GY, et al. Role of the gut microbiota in immunity and inflammatory disease［J］. Nat Rev Immunol, 2013, 13（5）:321-335.
［22］Ferreira CM, Vieira AT, Vinolo MA, et al. The central role of the gut microbiota in chronic inflammatory diseases［J］. J Immunol Res, 2014, 2014:689492.
［23］Maslowski KM, Vieira AT, Ng A, et al. Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43［J］. Nature, 2009, 461（7268）:1282-1286.
［24］Furusawa Y, Obata Y, Fukuda S, et al. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells［J］. Nature, 2013, 504（7480）:446-450.
［25］De Filippo C, Cavalieri D, Di Paola M, et al. Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa［J］. Proc Natl Acad Sci U S A, 2010, 107（33）:14691-14696.
［26］Breuer RI, Soergel KH, Lashner BA, et al. Short chain fatty acid rectal irrigation for left-sided ulcerative colitis: a randomised, placebo controlled trial［J］. Gut, 1997, 40（4）:485-491.
［27］Vernia P, Annese V, Bresci G, et al. Topical butyrate improves efficacy of 5-ASA in refractory distal ulcerative colitis: results of a multicentre trial［J］. Eur J Clin Invest, 2003, 33（3）:244-248.
［28］Sokol H, Seksik P, Furet JP, et al. Low counts of Faecalibacterium prausnitzii in colitis microbiota［J］. Inflamm Bowel Dis, 2009, 15（8）:1183-1189.
［29］Machiels K, Joossens M, Sabino J, et al. A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis［J］. Gut, 2014, 63（8）:1275-1283.
［30］Bjarnadottir TK, Gloriam DE, Hellstrand SH, et al. Comprehensive repertoire and phylogenetic analysis of the G protein-coupled receptors in human and mouse［J］. Genomics, 2006, 88（3）:263-273.
［31］Tolhurst G, Heffron H, Lam YS, et al. Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2［J］. Diabetes, 2012, 61（2）:364-371.
［32］Brown AJ, Goldsworthy SM, Barnes AA, et al. The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids［J］. J Biol Chem, 2003, 278（13）:11312-11319.
［33］Wang N, Guo DY, Tian X, et al. Niacin receptor GPR109A inhibits insulin secretion and is down-regulated in type  2 diabetic islet beta-cells［J］. Gen Comp Endocrinol, 2016, 237:98-108.
［34］Macia L, Tan J, Vieira AT, et al. Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome［J］. Nat Commun, 2015, 6:6734.
［35］Singh N, Gurav A, Sivaprakasam S, et al. Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis［J］. Immunity, 2014, 40（1）:128-139.
［36］Maslowski KM, Vieira AT, Ng A, et al. Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43［J］. Nature, 2009, 461（7268）:1282-1286.
［37］Sina C, Gavrilova O, Forster M, et al. G protein-coupled receptor 43 is essential for neutrophil recruitment during intestinal inflammation［J］. J Immunol, 2009, 183（11）:7514-7522.
［38］Singh N, Thangaraju M, Prasad PD, et al. Blockade of dendritic cell development by bacterial fermentation products butyrate and propionate through a transporter (Slc5a8)-dependent inhibition of histone deacetylases［J］. J Biol Chem, 2010, 285（36）:27601-27608.
［39］Singh N, Gurav A, Sivaprakasam S, et al. Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis［J］. Immunity, 2014, 40（1）:128-139.
［40］Trompette A, Gollwitzer ES, Yadava K, et al. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis［J］. Nat Med, 2014, 20（2）:159-166.
［41］Wu W, Sun M, Chen F, et al. Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43［J］. Mucosal Immunol, 2017, 10（4）:946-956.
［42］Arpaia N, Campbell C, Fan X, et al. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation［J］. Nature, 2013, 504（7480）:451-455.
［43］Smith PM, Howitt MR, Panikov N, et al. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis［J］. Science, 2013,341（6145）:569-573.
［44］Fleischer J, Bumbalo R, Bautze V, et al. Expression of odorant receptor Olfr78 in enteroendocrine cells of the colon［J］. Cell Tissue Res, 2015, 361（3）:697-710.
［45］Thangaraju M, Cresci G, Itagaki S, et al. Sodium-coupled transport of the short chain fatty acid butyrate by SLC5A8 and its relevance to colon cancer［J］. J Gastrointest Surg, 2008,12（10）:1773-1781, 1781-1782.
［46］Bose P, Dai Y, Grant S. Histone deacetylase inhibitor (HDACI) mechanisms of action: emerging insights［J］. Pharmacol Ther, 2014,143（3）:323-336.
［47］Dokmanovic M, Clarke C, Marks PA. Histone deacetylase inhibitors: overview and perspectives［J］. Mol Cancer Res, 2007, 5（10）:981-989.
［48］Johnstone RW. Histone-deacetylase inhibitors: novel drugs for the treatment of cancer［J］. Nat Rev Drug Discov, 2002,1（4）:287-299.
［49］Jin UH, Cheng Y, Park H, et al. Short chain fatty acids enhance aryl hydrocarbon (Ah) responsiveness in mouse colonocytes and caco-2 human colon cancer cells［J］. Sci Rep, 2017, 7（1）:10163.
［50］Koh A, De Vadder F, Kovatcheva-Datchary P, et al. From dietary fiber to host physiology: Short-chain fatty acids as key bacterial metabolites［J］. Cell, 2016, 165（6）:1332-1345.
［51］Thangaraju M, Carswell KN, Prasad PD, et al. Colon cancer cells maintain low levels of pyruvate to avoid cell death caused by  inhibition of HDAC1/HDAC3［J］. Biochem J, 2009, 417（1）:379-389.
［52］Singh N, Thangaraju M, Prasad PD, et al. Blockade of dendritic cell development by bacterial fermentation products butyrate and propionate through a transporter (Slc5a8)-dependent inhibition of histone deacetylases［J］. J Biol Chem, 2010, 285（36）:27601-27608.
［53］Chang PV, Hao L, Offermanns S, et al. The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition［J］. Proc Natl Acad Sci U S A, 2014,111（6）:2247-2252.
［54］Liu L, Li L, Min J, et al. Butyrate interferes with the differentiation and function of human monocyte-derived dendritic cells［J］. Cell Immunol, 2012,277（1/2）:66-73.
［55］Smith PM, Howitt MR, Panikov N, et al. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis［J］. Science, 2013,341(6145):569-573.
［56］Arpaia N, Campbell C, Fan X, et al. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation［J］. Nature, 2013, 504(7480):451-455.
［57］Park J, Kim M, Kang SG, et al. Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR-S6K pathway［J］. Mucosal Immunol, 2015,8（1）:80-93.
［58］Kim M, Qie Y, Park J, et al. Gut microbial metabolites fuel host antibody responses［J］. Cell Host Microbe, 2016, 20（2）:202-214.
［59］Singh NP, Singh UP, Singh B, et al. Activation of aryl hydrocarbon receptor (AhR) leads to reciprocal epigenetic regulation of FoxP3 and IL-17 expression and amelioration of experimental colitis［J］. PLOS ONE, 2011,6（8）:e23522.
［60］Kespohl M, Vachharajani N, Luu M, et al. The microbial metabolite butyrate induces expression of Th1-associated factors in CD4(+) T cells［J］. Front Immunol, 2017,8:1036.
［61］Kim MH, Kang SG, Park JH, et al. Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice［J］. Gastroenterology, 2013,145（2）:396-406.
［62］Hess J, Wang Q, Gould T, et al. Impact of Agaricus bisporus Mushroom Consumption on Gut Health Markers in Healthy Adults［J］. Nutrients, 2018,10(10).doi:10.3390/nu10101402.
［63］Coraci D, Giovannini S, Loreti C, et al. The past encounters the future: "old" diagnostic methods to check innovative treatments for carpal tunnel syndrome. Comment on: "Treatment of carpal tunnel syndrome: from ultrasonography to ultrasound surgery" by Petrover and Richette. Joint Bone Spine 2017 https://doi.org/10.1016/j.jbspin.2017.11.003［J］. Joint Bone Spine, 2018,85（6）:783-784.
［64］Takagi T, Naito Y, Higashimura Y, et al. Partially hydrolysed guar gum ameliorates murine intestinal inflammation in association with modulating luminal microbiota and SCFA［J］. Br J Nutr,2016, 116（7）:1199-1205.