关键词: 美罗培南, 合理用药, 临床疗效, 不良反应

Abstract:

AIM: To analyze the situation of clinical usage of meropenem in our hospital and to promote the rational usage of meropenem. METHODS: Ninety-seven medical records of meropenem hospitalized in our hospital from January 2016 to December 2017 were retrospectively analyzed for the drug usage, clinical efficacy, adverse reactions, and rationality of medication. RESULTS:Of the 97 patients, the top 3 departments using meropenem were surgical intensive care unit (23 cases, 23.71%), internal medicine intensive care unit (14 cases, 14.43%), and respiratory medicine department (11 cases, 11.34%). Seventy-six cases were cultured with bacteria, the submission rate was 78.35%, the defined daily doses (DDDs) of meropenem were 756.8, the drug utilization index (DUI) was 1.16, the adverse reaction rate was 15.46%, the total effective rate of clinical treatment was 85.57%, and the rational drug usage rate was 87.63%. The irrational drug usage rate was 12.37%, of which the non-indicative drug usage accounted for the highest proportion in all unreasonable drug usage cases. CONCLUSION: The clinical application of meropenem in our hospital is basically reasonable, but there are also cases of irrational usage. Clinical prescribes of meropenem should strictly follow the regulations to reduce experience-directed drug usage, improve the submission rate in order to enhance the efficacy of rational drug usage.

Key words: meropenem, rational drug usage, clinical efficacy, adverse reactions