调控Nrf2-Keap1-ARE信号通路的中药有效成分研究进展

中国临床药理学与治疗学 ›› 2015, Vol. 20 ›› Issue (6): 707-712.

调控Nrf2-Keap1-ARE信号通路的中药有效成分研究进展

戈孟雪¹,屈强²,周宏灏²

1. 中南大学湘雅医院临床药理研究所
2. 中南大学临床药理研究所

收稿日期:2015-01-12 修回日期:2015-02-15 出版日期:2015-06-26 发布日期:2015-06-29
通讯作者: 周宏灏 E-mail:hhzhou2003@163.com

Advances in study on effective components of Chinese medicine regulating Nrf2-Keap1-ARE signaling pathway

Received:2015-01-12 Revised:2015-02-15 Online:2015-06-26 Published:2015-06-29

摘要/Abstract

摘要： 氧化应激相关性疾病影响着人们的健康生活，Nrf2-Keap1-ARE信号通路是细胞氧化应激反应中的关键通路，其下游调控的II相代谢酶、抗氧化酶和药物转运蛋白参与肿瘤耐药和抗氧化应激。本文从Nrf2与Keap1结构功能、Nrf2-Keap1-ARE信号通路调节机制等方面，就可作用于Nrf2-Keap1-ARE信号通路的中药有效成分进行综述，为临床上运用中药复方及其有效成分预防和治疗氧化应激相关性疾病提供理论基础和思路。

Abstract: Oxidative stress related diseases affect people’s health. Nrf2-Keap1-ARE signaling pathway plays a vital role in the regulation of cellular oxidative stress response, and the downstream phase II detoxification enzymes, antioxidant enzymes and transporters are involved in tumor resistance and anti-oxidative stress. This paper focuses on the structure and function of Nrf2 and Keap1, the regulating mechanism of Nrf2-Keap1-ARE signaling pathway, and introduces effective components of Chinese medicine which can act on the Nrf2-Keap1-ARE signaling pathway. We aim to provide a theoretical basis for the clinical use of traditional Chinese medicine and its effective components, which can be used on prevention and treatment of oxidative stress related diseases.

戈孟雪, 屈强, 周宏灏. 调控Nrf2-Keap1-ARE信号通路的中药有效成分研究进展[J]. 中国临床药理学与治疗学, 2015, 20(6): 707-712.

GE Meng-Xue, QU Qiang, ZHOU Hong-Hao. Advances in study on effective components of Chinese medicine regulating Nrf2-Keap1-ARE signaling pathway[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2015, 20(6): 707-712.