Abstract: AIM: To observe anti-cold effects of the gantong granules in animals, such as inflammatory, febrifuge and relieving pain.METHODS: Some animal models were used to investigate the anti-inflammation, immunity functions of the gantong granules, including the auricular inflammation models, the feet swelling test, the cotton ball granulating proliferation test, the carbon particle clearance index test, hemolytic and febrifuge test, and lymphocyte counts.RESULTS: The gantong granules inhibited the auricular inflammation induced by dimethylbenzene in mice and the feet swelling induced be carrageenin in rats, and decreased the weights of cotton ball granulation tissues in rats. It also showed an increase in carbon particle clearance index K value and phagocytic index value in mice. Moreover it relieved pain with febrifuge, and potentiated the cellular immunity.CONCLUSION: The gantong granules show remarkable antiinflammatory effects and resistance to the cold.

Key words: gantong granules, inflammatory disease, immunity function, cold, animal models