Abstract: AIM: To evaluate HBV-marks after administration of famciclovir and ganyanling injection alone or in combination in the patients with chronic hepatitis B.METHODS: 112 patients with CHB were randomly assigned to three groups: 39 patients were alone administration of famciclovir 0. 5 mg, tid, po (famciclovir group), 33 patients were alone administration of ganyanling injection 4 ml, im, qod (ganyanling group), 40 patients were combination administration of famciclovir 0. 5 mg, tid, po and ganyanling injection 4 ml, im, qod (combination group). All the three groups were investigated for 24 weeks and 24 weeks after therapy. The levels of serum ALT, HBV-marks and HBV-DNA were detected before and after the treatment of 1, 3, 6, and 12 month. In addition, the conversion of HBeAg into HBeAb and the curative effect were observed.RESULTS: The normalization rates of serum ALT and HBV-DNA in combination group were higher than those in famciclovir group and ganyanling group (P<0. 05). There was no significant difference of the normalization rate of HBeAg among three groups. Few side effects were found in the course of treatment. CONCULSION: Famciclovir can inhibit the replication of HBVDNA more effectively than ganyanling injection. The combination administration of famciclovir and ganyanling injection is safe and effective in comparison with administration alone in patients with chronic HBV infection.

Key words: famciclovir, ganyanling injection, combination treatment, HBV-DNA, HBeAg