中国儿童保健杂志 ›› 2019, Vol. 27 ›› Issue (6): 629-632.DOI: 10.11852/zgetbjzz2019-0070

• 综述 • 上一篇    下一篇

益生菌预防早产儿坏死性小肠结肠炎的研究进展

冯梦妮1, 柯华2 综述, 李占魁2, 张莉2 审校   

  1. 1 西安医学院,陕西 西安 710021;
    2 西北妇女儿童医院新生儿科,陕西 西安 710061
  • 收稿日期:2019-01-16 出版日期:2019-06-10 发布日期:2019-06-10
  • 通讯作者: 李占魁,E-mail:13772151229@163.com
  • 作者简介:冯梦妮(1992-),女,湖北人,硕士研究生在读,主要研究方向为新生儿疾病。
  • 基金资助:
    国家自然科学基金(8187061481)

Research progress on probiotics in preventing necrotizing enterocolitis in premature infants

FENG Meng-ni1, KE Hua2, LI Zhan-kui2, ZHANG Li2   

  1. 1 Xi′an Medical College,Xi′an,Shaanxi 710021,China;
    2 Department of Neonatology,Northwest Women and Children Hospital,Xi′an,Shaanxi 710061,China
  • Received:2019-01-16 Online:2019-06-10 Published:2019-06-10
  • Contact: Corresponding author:LI Zhan-kui,E-mail:13772151229@163.com

摘要: 坏死性小肠结肠炎(NEC)是新生儿期一种极为严重的获得性胃肠道疾病,尤其多见于早产儿。因其发病率、死亡率以及预后不良风险较高,多年来一直备受关注,但其发病机制尚不完全清楚。近年来,有较多的研究指出肠道微生态失调与该疾病的发生密切相关,而益生菌作为一种调节肠道微生态的生物制剂逐渐受到研究者的重视。本文就新生儿肠道菌群特点及益生菌在预防早产儿NEC的相关研究热点作一综述。

关键词: 益生菌, 肠道菌群, 早产儿, 坏死性小肠结肠炎

Abstract: Necrotizing enterocolitis (NEC) is an extremely serious acquired gastrointestinal disease in the neonatal period,especially in premature infants.Because of its high morbidity,mortality and high risk of poor prognosis,NEC has been receiving much attention for many years,but its pathogenesis has not been fully understood.In recent years,there have been many studies pointing out that intestinal micro-ecological disorders are closely related to the occurrence of the disease.And probiotic,as a biological agent regulating intestinal micro-ecology,has gradually attracted the attention of researchers.This review summarizes the characteristics of neonatal intestinal flora and the research hotspots of probiotics in preventing NEC in premature infants.

Key words: probiotic, intestinal flora, premature, necrotizing enterocolitis

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