关键词: 哮喘, 血脂, 尿酸, 儿童

Abstract: Objective To analyze the changes of cardiovascular metabolic indicators such as blood lipids and serum uric acid in asthmatic children with different control levels, in order to determine the relationship between asthma control levels and cardiovascular metabolic risk factors. Methods A total of 88 asthmatic children who visited Zhengzhou Children's Hospital from October 2018 to December 2019 were selected as the case group, and were divided into well-controlled group and poorly-controlled group according to the asthma control level. Meanwhile, 30 healthy children were selected as the control group. The blood lipids, serum uric acid (sUA) and body mass index (BMI) levels of the asthmatic children were detected, and the lung function of the children in the case group was tested. Results There was no significant difference in the levels of low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), triglyceride (TG) and sUA between the case group and the control group (P>0.05). The level of high-density lipoprotein cholesterol (HDL-C) in the case group was significantly lower than that in the control group (t=-2.213,P＜0.05). The HDL-C level in the well-controlled group was significantly higher than that in the poorly-controlled group (t=2.692, P＜0.05), and the sUA level was significantly lower than that in the poorly-controlled group(t=-2.430, P＜0.05). The FEV1% pred level in the well-controlled group was significantly higher than that in the poorly-controlled group (t=9.741, P＜0.05). The FEV1% pred level of asthmatic children in the poorly controlled group was positively correlated with HDL-C level (r=0.457, P＜0.01), and negatively correlated with sUA level (r=-0.671,P＜0.01). Conclusion The control level of asthma in children is related to the levels of HDL-C and sUA, and the decrease of HDL-C and the increase of sUA may be the risk factors for poor control of asthma and poor lung function in children.

Key words: asthma, blood lipid, uric acid, children