中国儿童保健杂志 ›› 2015, Vol. 23 ›› Issue (5): 519-521.DOI: 10.11852/zgetbjzz2015-23-05-23

• 临床研究与分析 • 上一篇    下一篇

不同营养方式对早产儿生长和胃肠激素水平的影响

高改兰1, 刘俐2, 汤淑斌3, 李杰1, 李维娜1, 杨艳1   

  1. 1 宝鸡市第二人民医院儿科, 陕西 宝鸡 721000;
    2 西安交通大学医学院第一附属医院新生儿科, 陕西 西安 710061;
    3 宝鸡市儿童医院, 陕西 宝鸡 721000
  • 收稿日期:2014-09-09 发布日期:2015-05-10 出版日期:2015-05-10
  • 通讯作者: 刘俐
  • 作者简介:高改兰(1964-), 女, 陕西人, 副主任医师, 本科学历, 主要研究方向为儿科疾病。
  • 基金资助:
    宝鸡市卫生局市级科研课题(2013-54)

lnfluence of different nutrition ways to growth and gastrointestinal hormone in premature infants.

GAO Gai-lan1, LIU Li2, TANG Shu-bin3, LI Jie1, LI Wei-na1, YANG Yan1.   

  1. 1 Department of Pediatrics, Baoji Second People's Hospital, Baoji, Shaanxi 721000, China;
    2 Department of Neonatology, the First Affiliated Hospital of Xi'an Jiaotong University, Xian, Shaanxi 710061, China;
    3 Chidren's Hospital of Baoji, Baoji, Shaanxi 721000, China
  • Received:2014-09-09 Online:2015-05-10 Published:2015-05-10
  • Contact: LIU Li, E-mail:liuli918@163.com

摘要: 目的 研究早产儿早期不同的营养方式对出院时体重(宫外发育迟缓)和胃肠激素的影响。方法 采用临床对照研究的方法 , 选择2011年1月-2014年12月入住宝鸡市第二人民医院新生儿重症监护室的早产儿共106例, 随机分为观察组和对照组, 观察组采用早期胃肠内外营养, 微量喂养代替禁食, 管饲的同时采取非营养性吸吮。对照组采取晚喂养, 喂养不耐受时禁食, 喂养过程中未采取非营养性吸吮。监测体重等生长发育指标和生后2 d内、7~9 d、13~15 d血清胃动素和胃泌素水平。结果 1)观察组患儿体重开始增长时间、达全肠道喂养时间及恢复出生体重时间均较对照组缩短[(7.28±6.25)比(10.8±5.07)d, (11.16±4.32)比(18.43±9.72)d, (8.21±3.72)d比(13.84±5.46)d], 住院天数较对照组短(16.82±2.2)d比(19.91±2.3)d, 宫外发育迟缓发生率较对照组低(40.30%比65.38%), 生后2 d内及7~9 d胃动素水平高于对照组[(348.6±177.6)pg/mL比(246.3±95.6)pg/mL, (492.3±235.8)pg/mL比(342.2±141.5)pg/mL], 13~15 d胃泌素水平高于对照组[(75.2±12.9)pg/mL比(58.9±16.5)pg/mL], 差异均有统计学意义(P均<0.05)。2)体重增长速度和生后2 d内及7~9 d测得的胃泌素水平差异均无统计学意义(P>0.05)。结论 早期实施胃肠内外营养可有效降低宫外生长迟缓的发生率。

关键词: 早产儿, 胃肠内外营养, 体重, 宫外生长迟缓

Abstract: Objective To study the effects of different nutrition on preterm children's weight (extrauterine growth retardation, EUGR) and gastrointestinal hormone. Methods Using the Methods of control study clinical, a total of 106 premature children who stay in Baoji Second People's hospital NICU from January 2011 to December 2014, were selected and randomly divided into observation group and control group, the observation group received enteral and parenteral nutrition, micro-feeding instead of fasting, tube feeding while taking non-nutritive sucking, the control group received evening feeding, fasting during feeding intolerance, feeding process without non-nutritive sucking.The weight and other growth indicators, the serum motilin and gastrin levels of 2 d, 7~9 d, 13~15 d after birth were monitored. Results 1)The increase time of weight, time reaching full enteral feeding and recovery time of birth weight of observation group were shorter[(7.28±6.25)d to(10.8±5.07)d, (11.16±4.32)d to(18.43±9.72)d, (8.21±3.72)d to (13.84±5.46)d], the days in hospital was shorter(16.82±2.2)d to (19.91±2.3)d, and the rate of extrauterine growth retardation was lower(40.30% to 65.38%), motilin levels of the babies who birth 2 d and 7~9 d were higher[(348.6±177.6)pg/mL to(246.3±95.6)pg/mL, (492.3±235.8)pg/mL to(342.2±141.5)pg/mL], gastrin levels of birth 13~15 d was higher[(75.2±12.9)pg/mL to(58.9±16.5)pg/mL], differences were statistically significant (P<0.05).2) The differences of growth rate, and the gastrin levels of birth 2 d and 7~9 d had no statistically significant (P>0.05). Conclusion Implementation of enteral and parenteral nutrition can effectively reduce incidence of extrauterine growth retardation.

Key words: preterm children, enteral and parenteral nutrition, weight, extrauterine growth retardation

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