脂质型人工泪液对行超声乳化吸除术的白内障患者术后干眼的临床研究

doi:10.12092/j.issn.1009-2501.2018.12.011

中国临床药理学与治疗学 ›› 2018, Vol. 23 ›› Issue (12): 1380-1385.doi: 10.12092/j.issn.1009-2501.2018.12.011

脂质型人工泪液对行超声乳化吸除术的白内障患者术后干眼的临床研究

陈战巧，钟柳美，李霞，应锦河

丽水市中心医院眼科，丽水 323000，浙江

收稿日期:2018-07-18 修回日期:2018-10-29 出版日期:2018-12-26 发布日期:2018-12-27
作者简介:陈战巧，女，本科，副主任医师，研究方向：白内障、青光眼、眼底病。 Tel：13906882433 E-mail：chenzhanczq@163.com
基金资助:
浙江省医药卫生科技项目（2014KYA232）

Clinical study of lipid type artificial tear in cataract patients with postoperative dry eye by phacoemulsification

CHEN Zhanqiao, ZHONG Liumei, LI Xia, YING Jinhe

Department of Ophthalmology, Lishui Central Hospital, Lishui 323000, Zhejiang, China

Received:2018-07-18 Revised:2018-10-29 Online:2018-12-26 Published:2018-12-27

摘要/Abstract

摘要：

目的: 探讨脂质型人工泪液对行超声乳化吸除术的白内障术后干眼患者的临床疗效。方法: 选择2015年3月至2017年5月在我院行超声乳化吸除术的白内障术后干眼患者90例，共90只眼，按照随机数字表法将其分为观察组和对照组，两组各45例，对照组使用玻璃酸钠滴眼液，观察组使用脂质型人工泪液（凝胶卡波姆）滴术眼，于术前及术后1周、术后1个月、术后3个月对两组患者进行眼表疾病指数（OSDI）调查、泪膜破裂时间（BUT）检查、角膜荧光染色（CFS）评分以及基础泪液分泌（SIT）试验。结果: 观察组总有效率88.1%，对照组总有效率65.0%，观察组总有效率明显高于对照组（P<0.05）；术后1周，两组患者的OSDI评分比较差异无统计学意义（P>0.05），术后1个月、3个月，两组患者OSDI评分均明显低于术后1周（P<0.05），且观察组OSDI评分明显低于对照组（P<0.05）；术后1周、1个月、3个月观察组BUT均明显高于对照组（P<0.05）；术后1周、1个月、3个月观察组CFS评分均明显低于对照组（P<0.05）；术后1周，两组患者SIT试验结果比较差异无统计学意义（P>0.05），术后1个月、3个月观察组SIT试验结果均明显优于对照组（P<0.05）。结论: 脂质型人工泪液对行超声乳化吸除术的白内障术后干眼患者的治疗效果好，可明显缓解患者干眼症状，促进泪膜恢复，值得临床推广。

关键词: 脂质型人工泪液, 超声乳化吸除术, 白内障, 术后干眼

Abstract:

AIM: To investigate the clinical effect of lipid artificial tears on patients with dry eye after phacoemulsification. METHODS: A total of 90 cases of dry eyes after cataract surgery were selected after phacoemulsification in our hospital from March 2015 to May 2017 and they were divided into observation group (45 cases) and control group (45 cases) according to the random number table method, the control group used sodium hyaluronate eye drops, the observation group used lipid type artificial tears (gel carbomer), the two groups were tested for ocular surface disease index (OSDI), break-up time (BUT), corneal fluorescein staining (CFS) and schirmer I test (SIT) at preoperative, one week after operation, one month after operation and three months after operation. RESULTS:The total effective rate of observation group (88.1%) was significantly higher than that (65.0%) of control group (P<0.05); one week after operation, there was no statistically significant difference in OSDI scores between the two groups (P>0.05); one month and three months after operation, OSDI scores in both groups were significantly lower than one week after operation (P<0.05), and the OSDI score of observation group was significantly lower than that of control group (P<0.05); one week, one month and three months after operation, the BUT of observation group were significantly higher than those of control group (P<0.05); one week, one month and three months after operation, the CFS scores of observation group were significantly lower than those of control group (P<0.05); one week after operation, there was no statistically significant difference in SIT experiment results between the two groups (P>0.05); one month and three months after operation, the results of the SIT experiment were significantly better than that of control group (P<0.05). CONCLUSION: Lipid-type artificial tear is effective in treating patients with dry eye after phacoemulsification, and it can obviously alleviate the patient's dry eye symptoms and helps the recovery of tear film, which is worthy of clinical promotion.

Key words: lipid type artificial tear, phacoemulsification, cataract, postoperative dry eye

中图分类号:

陈战巧，钟柳美，李霞，应锦河. 脂质型人工泪液对行超声乳化吸除术的白内障患者术后干眼的临床研究[J]. 中国临床药理学与治疗学, 2018, 23(12): 1380-1385.

CHEN Zhanqiao, ZHONG Liumei, LI Xia, YING Jinhe. Clinical study of lipid type artificial tear in cataract patients with postoperative dry eye by phacoemulsification[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(12): 1380-1385.

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脂质型人工泪液对行超声乳化吸除术的白内障患者术后干眼的临床研究

Clinical study of lipid type artificial tear in cataract patients with postoperative dry eye by phacoemulsification

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