阿尔茨海默症体外模型研究进展

doi:10.12092/j.issn.1009-2501.2020.10.014

摘要/Abstract

摘要： 阿尔茨海默症（AD）是一种严重影响患者生活质量的神经退行性疾病。迄今为止，AD的具体发病机制仍尚未阐明，仅有的5个批准上市的抗AD药物也存在副作用明显、疗效有限等问题。理想的疾病模型是探究病因与开发新药的重要工具。本文以传统“诱导型”AD体外模型为中心，对模型诱导剂、基本原理、主要特征和应用实例等方面进行阐述，同时总结近年来新型AD体外模型研究进展，以期为研究人员提供参考和指导。

关键词: 阿尔茨海默症, 体外模型, 模型诱导剂

Abstract: Alzheimer's disease (AD) is a neurodegenerative disease that seriously affects the quality of life of patients. Hitherto, the specific pathogenesis of AD has not been clarified and the only 5 anti-AD drugs approved for marketing also have some problems such as obvious side effects and limited efficacy. The ideal disease model is an important tool to explore the etiology and develop new drugs. This paper focuses on the traditional "induced" AD model in vitro. The modeling agents, basic principle, main characteristics and application examples are described, and the research progress of new AD models in vitro in recent years are summarized, in order to provide reference and guidance for researchers to study AD.

Key words: Alzheimer's disease, model in vitro, modeling agent

中图分类号:

R741

李红星, 张信岳, 武柠子, 谷丽丽, 鲁佳琪, 张玲希, 李钦. 阿尔茨海默症体外模型研究进展[J]. 中国临床药理学与治疗学, 2020, 25(10): 1178-1187.

LI Hongxing, ZHANG Xinyue, WU Ningzi, GU Lili, LU Jiaqi, ZHANG Lingxi, LI Qin. Research progress on model of Alzheimer's disease in vitro#br#[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2020, 25(10): 1178-1187.

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